IRS2 Antibody (676415) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IRS2 (insulin receptor substrate 2) is a 180-190 kDa substrate intermediate that lies between various cytokine receptors and downstream signaling molecules.  It is the primary IRS protein found in hematopoietic cells.  Depending upon the receptor, IRS2 undergoes phosphorylation, either via Tyk2 following type I IFN binding, or via JAK1 and 3 following IL-4, -7 and -15 binding.  This event allows for its subsequent association with PI-3 kinase.  Human IRS2 is 1338 amino acids (aa) in length with a predicted MW of 138 kDa.  It contains one PH (pleckstrin homology) domain (aa 16-144), followed by a PTB (phosphotyrosine-binding)domain (aa 194-298) and seven YxxM (Tyr/x/x/Met) motifs (aa 540-1075).  IRS2 is phosphorylated on multiple Ser and Tyr residues.  There are two potential splice variants. One shows a 16 aa substitution for the C-terminal Glu, while another shows an 11 aa substitution for aa 1314-1338.  Over aa 1035-1136, human IRS2 shares 86% aa identity with mouse IRS2. 

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publication 1 - 1 of 1.

Publication using MAB6347	Applications	Species
I Pablos, Y Machado, HCR de Jesus, Y Mohamud, R Kappelhoff, C Lindskog, M Vlok, PA Bell, GS Butler, PM Grin, QT Cao, JP Nguyen, N Solis, S Abbina, W Rut, JC Vederas, L Szekely, A Szakos, M Drag, JN Kizhakkeda, K Mossman, JA Hirota, E Jan, H Luo, A Banerjee, CM Overall Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome Cell Reports, 2021-10-09;37(4):109892. 2021-10-09 [PMID: 34672947]

Array MAB6347

• IRS2 Antibodies
• IRS2 Lysate
• IRS2 Proteins