Human TGF-beta 2 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TGF-beta 2 is synthesized as a prepro-cytokine with a 19 amino acid (aa) signal sequence, a 283 aa pro-region, and a 112 aa mature segment (1-5). It dimerizes with formation of disulfide bonds between the 'pro' regions and disulfide bonds between the 'mature' regions. The mature region is 71% and 80% identical with human TGF-beta 1 and TGF-beta 3 (6, 7) and 97% identical with the corresponding mouse protein (8). After proteolytic cleavage of the disulfide-linked mature region, it remains hydrogen-bonded to the disulfide-linked prosegments (LAP or latencyassociated protein) (1, 2, 9). If secreted in this form, LAP keeps TGF-beta 2 in an inactive state until dissociation, caused by proteases, glycosidases, or extreme pH (2, 9). In many types of cells, an additional protein, latent TGF-beta binding protein (LTBP), is covalently linked to the LAP homodimer prior to secretion. LTBP, a 130 kDa cysteine-rich glycoprotein, creates a 235 kDa large latent complex that is secreted, most likely binding to the extracellular matrix (1, 9-11). The latency components are believed to act as natural antagonists of TGF-beta activity, to target TGF-beta to distinct tissues, and to maintain a reservoir of TGF-beta (1, 2, 12). On release from latency, active homodimeric TGF-beta can bind to cell-surface receptors or to other proteins, such as alpha ₂-macroglobulin (13). 

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Chicken.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using DY302	Applications	Species
AN Mwaura, MA Riaz, JB Maoga, E Mecha, COA Omwandho, G Scheiner-B, I Meinhold-H, L Konrad Role of Betaglycan in TGF-beta Signaling and Wound Healing in Human Endometriotic Epithelial Cells and in Endometriosis Biology, 2022-03-26;11(4):. 2022-03-26 [PMID: 35453712] (Human)		Human
NB Nataraj, A Noronha, JS Lee, S Ghosh, HR Mohan Raju, A Sekar, B Zuckerman, M Lindzen, E Tarcitano, S Srivastava, M Selitrenni, I Livneh, D Drago-Garc, O Rueda, C Caldas, S Lev, T Geiger, A Ciechanove, I Ulitsky, R Seger, E Ruppin, Y Yarden Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors Cell Reports, 2022-02-22;38(8):110418. 2022-02-22 [PMID: 35196484] (Human)		Human
D Halbgebaue, J Roos, JB Funcke, H Neubauer, BS Hamilton, E Simon, EZ Amri, KM Debatin, M Wabitsch, P Fischer-Po, D Tews Latent TGFbeta-binding proteins regulate UCP1 expression and function via TGFbeta2 Molecular Metabolism, 2021-09-01;53(0):101336. 2021-09-01 [PMID: 34481123] (Human)		Human
G Liu, H Li, W Zhang, J Yu, X Zhang, R Wu, M Niu, X Liu, R Yu Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma Journal of Cellular and Molecular Medicine, 2021-07-03;0(0):. 2021-07-03 [PMID: 34216174] (Human)		Human
E Krepela, Z Vanickova, P Hrabal, M Zubal, B Chmielova, E Balaziova, P Vymola, I Matrasova, P Busek, A Sedo Regulation of Fibroblast Activation Protein by Transforming Growth Factor Beta-1 in Glioblastoma Microenvironment International Journal of Molecular Sciences, 2021-01-21;22(3):. 2021-01-21 [PMID: 33494271] (Human)		Human
JH Ko, HJ Kim, HJ Jeong, HJ Lee, JY Oh Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis Cell Rep, 2020-03-17;30(11):3806-3820.e6. 2020-03-17 [PMID: 32187551] (Human)		Human
G Begum, J O'Neill, R Chaudhary, K Blachford, DRJ Snead, M Berry, RAH Scott, A Logan, RJ Blanch Altered Decorin Biology in Proliferative Vitreoretinopathy: A Mechanistic and Cohort Study Invest. Ophthalmol. Vis. Sci., 2018-10-01;59(12):4929-4936. 2018-10-01 [PMID: 30347087] (Human)		Human
SE Logue, EP McGrath, P Cleary, S Greene, K Mnich, A Almanza, E Chevet, RM Dwyer, A Oommen, P Legembre, F Godey, EC Madden, B Leuzzi, J Obacz, Q Zeng, JB Patterson, R Jäger, AM Gorman, A Samali Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy Nat Commun, 2018-08-15;9(1):3267. 2018-08-15 [PMID: 30111846] (Human)		Human
Young V, Brown J, Saunders P, Duncan W, Horne A The peritoneum is both a source and target of TGF-beta in women with endometriosis. PLoS ONE, 2014-09-10;9(9):e106773. 2014-09-10 [PMID: 25207642] (Human)		Human
Reeves S, Kolstad T, Lien T, Elliott M, Ziegler S, Wight T, Debley J Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components. J Allergy Clin Immunol, 2014-05-27;134(3):663-670.e1. 2014-05-27 [PMID: 24875618] (Human)		Human
Cakstina I, Riekstina U, Boroduskis M, Nakurte I, Ancans J, Zile M, Muiznieks I Primary culture of avian embryonic heart forming region cells to study the regulation of vertebrate early heart morphogenesis by vitamin A. BMC Dev Biol, 2014-02-19;14(0):10. 2014-02-19 [PMID: 24552295] (Chicken)		Chicken
Seeger P, Bosisio D, Parolini S, Badolato R, Gismondi A, Santoni A, Sozzani S Activin A as a mediator of NK-dendritic cell functional interactions. J Immunol, 2014-01-06;192(3):1241-8. 2014-01-06 [PMID: 24395917] (Human)		Human
Hawinkels L, Paauwe M, Verspaget H, Wiercinska E, van der Zon J, van der Ploeg K, Koelink P, Lindeman J, Mesker W, ten Dijke P, Sier C Interaction with colon cancer cells hyperactivates TGF-beta signaling in cancer-associated fibroblasts. Oncogene, 2012-12-03;33(1):97-107. 2012-12-03 [PMID: 23208491] (Human)		Human
Pen A, Moreno MJ, Durocher Y, Deb-Rinker P, Stanimirovic DB Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling. Oncogene, 2008-08-18;27(54):6834-44. 2008-08-18 [PMID: 18711401] (Human)		Human
Gaide Chevronnay HP, Cornet PB, Delvaux D, Lemoine P, Courtoy PJ, Henriet P, Marbaix E Opposite regulation of transforming growth factors-beta2 and -beta3 expression in the human endometrium. Endocrinology, 2007-11-26;149(3):1015-25. 2007-11-26 [PMID: 18039789] (Human)		Human
Alcorn JF, Rinaldi LM, Jaffe EF, van Loon M, Bates JH, Janssen-Heininger YM, Irvin CG Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease. Am. J. Respir. Crit. Care Med., 2007-08-29;176(10):974-82. 2007-08-29 [PMID: 17761617] (Mouse)		Mouse
Neurohr C, Nishimura SL, Sheppard D Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am. J. Respir. Cell Mol. Biol., 2006-03-30;35(2):252-9. 2006-03-30 [PMID: 16574941] (Human)		Human
Rendi MH, Suh N, Lamph WW, Krajewski S, Reed JC, Heyman RA, Berchuck A, Liby K, Risingsong R, Royce DB, Williams CR, Sporn MB The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer. Cancer Res., 2004-05-15;64(10):3566-71. 2004-05-15 [PMID: 15150113] (Rat)		Rat
Show All 18 Publications. Collapse Publications.

Array DY302

• TGF-beta 2 Antibodies
• TGF-beta 2 ELISA Kits
• TGF-beta 2 Lysate
• TGF-beta 2 Proteins and Enzymes
• TGF-beta 2 ELISAs