Human Thrombospondin-1 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Thrombospondins (TSP) are secreted multidomain glycoproteins with many putative functions including modulating cell adhesion, proliferation, migration, and angiogenesis. At least five TSPs exist: TSP-1, -2, -3, -4, and cartilage oligomeric glycoprotein (COMP)/TSP-5. The family can be divided into two subgroups. The first, TSP-1 and -2, are homotrimeric molecules, each monomer containing an N-terminal/heparin-binding domain, a coiled-coil oligomerization domain, a von Willebrand factor-type/procollagen homology domain, three type 1 thrombospondin repeats (TSR), three EGF-like repeats, seven TSP type 3 repeats, and a C-terminal globular domain. TSP-1 and -2 are thought to mediate interactions between cells and the extracellular matrix, and as such are matricellular proteins. In contrast, TSP-3, -4, and COMP/TSP-5 are homopentamers that lack the N-terminal structure of TSP-1 and -2, but have a similar arrangement of EGF and TSP type 3 repeats, and the C-terminal domain characteristic of the TSP family.

We have publications tested in 3 confirmed species: Human, Mouse, Complex Species Category.

Showing Publications 1 - 10 of 38. Show All 38 Publications. Collapse Publications.

Publications using DTSP10	Applications	Species
Krishna, S;Choudhury, A;Keough, MB;Seo, K;Ni, L;Kakaizada, S;Lee, A;Aabedi, A;Popova, G;Lipkin, B;Cao, C;Nava Gonzales, C;Sudharshan, R;Egladyous, A;Almeida, N;Zhang, Y;Molinaro, AM;Venkatesh, HS;Daniel, AGS;Shamardani, K;Hyer, J;Chang, EF;Findlay, A;Phillips, JJ;Nagarajan, S;Raleigh, DR;Brang, D;Monje, M;Hervey-Jumper, SL; Glioblastoma remodelling of human neural circuits decreases survival Nature 2023-05-03 [PMID: 37138086] (Human)		Human
L Oldfield, A Evans, RG Rao, C Jenkinson, T Purewal, EE Psarelli, U Menon, JF Timms, SP Pereira, P Ghaneh, W Greenhalf, C Halloran, E Costello Blood levels of adiponectin and IL-1Ra distinguish type 3c from type 2 diabetes: Implications for earlier pancreatic cancer detection in new-onset diabetes EBioMedicine, 2022-01-03;75(0):103802. 2022-01-03 [PMID: 34990893] (Human)		Human
E Fernández-, C Lleixà, X Suarez-Cal, J Diaz-Maner, I Illa, E Gallardo, N de Luna Proteasome inhibitors reduce thrombospondin-1 release in human dysferlin-deficient myotubes BMC Musculoskelet Disord, 2020-11-27;21(1):784. 2020-11-27 [PMID: 33246442] (Human)		Human
U Alehagen, L Shamoun, D Wågsäter Increased cardiovascular mortality in females with the a/a genotype of the SNPs rs1478604 and rs2228262 of thrombospondin-1 BMC Med. Genet., 2020-09-11;21(1):179. 2020-09-11 [PMID: 32917134] (Human)		Human
M Mussbacher, TL Krammer, S Heber, WC Schrottmai, S Zeibig, HP Holthoff, D Pereyra, P Starlinger, M Hackl, A Assinger Impact of Anticoagulation and Sample Processing on the Quantification of Human Blood-Derived microRNA Signatures Cells, 2020-08-18;9(8):. 2020-08-18 [PMID: 32824700] (Human)		Human
SP Polster, A Sharma, C Tanes, AT Tang, P Mericko, Y Cao, J Carrión-Pe, R Girard, J Koskimäki, D Zhang, A Stadnik, SG Romanos, SB Lyne, R Shenkar, K Yan, C Lee, A Akers, L Morrison, M Robinson, A Zafar, K Bittinger, H Kim, JA Gilbert, ML Kahn, L Shen, IA Awad Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma Nat Commun, 2020-05-27;11(1):2659. 2020-05-27 [PMID: 32461638] (Human)		Human
H Yagi, M Nishigori, Y Murakami, T Osaki, S Muto, Y Iba, K Minatoya, Y Ikeda, H Ishibashi-, T Morisaki, H Ogino, H Tanaka, H Sasaki, H Matsuda, N Minamino Discovery of novel biomarkers for atherosclerotic aortic aneurysm through proteomics-based assessment of disease progression Sci Rep, 2020-04-14;10(1):6429. 2020-04-14 [PMID: 32286426] (Human)		Human
S Lie, BR Vieira, S Arruda, M Simões, LM Ashander, JM Furtado, JR Smith Molecular Basis of The Retinal Pigment Epithelial Changes That Characterize The Ocular Lesion in Toxoplasmosis Microorganisms, 2019-09-29;7(10):. 2019-09-29 [PMID: 31569536] (Human)		Human
YY Joo, JW Jang, SW Lee, SH Yoo, JH Kwon, SW Nam, SH Bae, JY Choi, SK Yoon Circulating pro- and anti-angiogenic factors in multi-stage liver disease and hepatocellular carcinoma progression Sci Rep, 2019-06-24;9(1):9137. 2019-06-24 [PMID: 31235729] (Human)		Human
T Daubon, C Léon, K Clarke, L Andrique, L Salabert, E Darbo, R Pineau, S Guérit, M Maitre, S Dedieu, A Jeanne, S Bailly, JJ Feige, H Miletic, M Rossi, L Bello, F Falciani, R Bjerkvig, A Bikfalvi Deciphering the complex role of thrombospondin-1 in glioblastoma development Nat Commun, 2019-03-08;10(1):1146. 2019-03-08 [PMID: 30850588] (Human)		Human
S Haegele, J Fuxsteiner, D Pereyra, C Koeditz, B Rumpf, C Schuetz, C Schwarz, C Brostjan, T Gruenberge, P Starlinger Elevated ADAMTS13 Activity is Associated with Poor Postoperative Outcome in Patients Undergoing Liver Resection Sci Rep, 2018-11-14;8(1):16823. 2018-11-14 [PMID: 30429491] (Human)		Human
K Watt, D Newsted, E Voorand, RJ Gooding, A Majewski, P Truesdell, B Yao, T Tuschl, N Renwick, AW Craig MicroRNA-206 suppresses TGF-? signalling to limit tumor growth and metastasis in lung adenocarcinoma Cell. Signal., 2018-06-20;50(0):25-36. 2018-06-20 [PMID: 29935234] (Human)		Human
S Yang, R Song, X Li, T Zhang, J Fu, X Cui Thrombospondin-2 predicts response to treatment with intravenous immunoglobulin in children with Kawasaki disease BMJ Paediatr Open, 2018-01-03;2(1):e000190. 2018-01-03 [PMID: 29637185] (Human)		Human
M Mussbacher, WC Schrottmai, M Salzmann, C Brostjan, JA Schmid, P Starlinger, A Assinger Optimized plasma preparation is essential to monitor platelet-stored molecules in humans PLoS ONE, 2017-12-08;12(12):e0188921. 2017-12-08 [PMID: 29220362] (Human)		Human
D Muramatsu, M Okabe, A Takaoka, H Kida, A Iwai Aureobasidium pullulans produced ?-glucan is effective to enhance Kurosengoku soybean extract induced Thrombospondin-1 expression Sci Rep, 2017-06-06;7(1):2831. 2017-06-06 [PMID: 28588201] (Human)		Human
AT Amaraseker, B Assadi-Kha, S Liu, M Black, G Dymmott, NM Rogers, AL Sverdlov, JD Horowitz, DTM Ngo Vitamin D supplementation lowers thrombospondin-1 levels and blood pressure in healthy adults PLoS ONE, 2017-05-10;12(5):e0174435. 2017-05-10 [PMID: 28489857] (Human)		Human
S Chandran, J Watkins, A Abdul-Aziz, M Shafat, PA Calvert, KM Bowles, MD Flather, SA Rushworth, AD Ryding Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction J Am Heart Assoc, 2017-05-03;6(5):. 2017-05-03 [PMID: 28468787] (Human)		Human
C Di Mauro, R Rosa, V D'Amato, P Ciciola, A Servetto, R Marciano, RC Orsini, L Formisano, S De Falco, V Cicatiello, M Di Bonito, M Cantile, F Collina, A Chambery, BM Veneziani, S De Placido, R Bianco Hedgehog signalling pathway orchestrates angiogenesis in triple-negative breast cancers Br. J. Cancer, 2017-04-25;0(0):. 2017-04-25 [PMID: 28441382] (Human, Mouse)		Human, Mouse
Unaltered Angiogenesis-Regulating Activities of Platelets in Mild Type 2 Diabetes Mellitus despite a Marked Platelet Hyperreactivity PLoS ONE, 2016-09-09;11(9):e0162405. 2016-09-09 [PMID: 27612088] (Human)		Human
Verstraete M, Debucquoy A, Dekervel J, Van Pelt J, Verslype C, Devos E, Chiritescu G, Dumon K, D'Hoore A, Gevaert O, Sagaert X, Van Cutsem E, Haustermans K Combining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial. Br J Cancer, 2015-03-17;112(8):1314-25. 2015-03-17 [PMID: 25867261] (Human)		Human
Gokyu M, Kobayashi H, Nanbara H, Sudo T, Ikeda Y, Suda T, Izumi Y Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells. PLoS ONE, 2014-12-12;9(12):e115107. 2014-12-12 [PMID: 25501558] (Human)		Human
Yao L, Dong H, Luo Y, Du J, Hu W Net platelet angiogenic activity (NPAA) correlates with progression and prognosis of non-small cell lung cancer. PLoS ONE, 2014-04-30;9(4):e96206. 2014-04-30 [PMID: 24788022] (Human)		Human
Armstrong A, Haggman M, Stadler W, Gingrich J, Assikis V, Polikoff J, Damber J, Belkoff L, Nordle O, Forsberg G, Carducci M, Pili R Long-term survival and biomarker correlates of tasquinimod efficacy in a multicenter randomized study of men with minimally symptomatic metastatic castration-resistant prostate cancer. Clin Cancer Res, 2013-11-19;19(24):6891-901. 2013-11-19 [PMID: 24255071] (Human)		Human
Tsuchida , R, Osawa , T, Wang , F, Nishii , R, Das , B, Tsuchida , S, Muramatsu , M, Takahashi , T, Inoue , T, Wada , Y, Minami , T, Yuasa , Y, Shibuya , M BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors. Oncogene, 2013-09-09;33(29):3803-11. 2013-09-09 [PMID: 24013228] (Human)		Human
Goretti E, Rolland-Turner M, Leonard F, Zhang L, Wagner D, Devaux Y MicroRNA-16 affects key functions of human endothelial progenitor cells. J Leukoc Biol, 2013-01-16;93(5):645-55. 2013-01-16 [PMID: 23325924] (Human)		Human
Lindner D, Wu Y, Haney R, Jacobs B, Fruehauf J, Tuthill R, Borden E Thrombospondin-1 expression in melanoma is blocked by methylation and targeted reversal by 5-Aza-deoxycytidine suppresses angiogenesis. Matrix Biol, 2012-11-30;32(2):123-32. 2012-11-30 [PMID: 23202046] (Human)		Human
Metronomic activity of CD44-targeted hyaluronic acid-paclitaxel in ovarian carcinoma. Clin. Cancer Res., 2012-06-12;18(15):4114-21. 2012-06-12 [PMID: 22693353] (Complex Species Category)		Complex Species Category
Predictors of thromboxane levels in patients with non-ST-elevation acute coronary syndromes on chronic aspirin therapy. Thromb. Haemost., 2012-04-26;108(1):133-9. 2012-04-26 [PMID: 22535468] (Human)		Human
Firlej V, Mathieu JR, Gilbert C, Lemonnier L, Nakhle J, Gallou-Kabani C, Guarmit B, Morin A, Prevarskaya N, Delongchamps NB, Cabon F Thrombospondin-1 triggers cell migration and development of advanced prostate tumors. Cancer Res., 2011-10-28;71(24):7649-58. 2011-10-28 [PMID: 22037878] (Human)		Human
Loupakis F, Cremolini C, Fioravanti A Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer. Br. J. Cancer, 2011-03-15;104(8):1262-9. 2011-03-15 [PMID: 21407216] (Human)		Human
Vazquez Lopez MA, Llamas MA, Galera R, Sanchez AR, Lendinez F, Gonzalez-Ripoll M, Diez J, Bonillo A Comparison between one and three doses a week of recombinant erythropoietin in very low birth weight infants. J Perinatol, 2010-08-05;31(0):118-24. 2010-08-05 [PMID: 20689518] (Human)		Human
Mittal R, Gonzalez-Gomez I, Prasadarao NV Escherichia coli K1 promotes the ligation of CD47 with thrombospondin-1 to prevent the maturation of dendritic cells in the pathogenesis of neonatal meningitis. J. Immunol., 2010-07-30;185(5):2998-3006. 2010-07-30 [PMID: 20675593] (Human)		Human
Ding W, Knox TR, Tschumper RC Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch. Blood, 2010-07-06;116(16):2984-93. 2010-07-06 [PMID: 20606160] (Human)		Human
Starlinger P, Moll HP Thrombospondin-1: a unique marker to identify in vitro platelet activation when monitoring in vivo processes. J. Thromb. Haemost., 2010-05-12;0(0):. 2010-05-12 [PMID: 20492458] (Human)		Human
Olsson A, Bjork A, Vallon-Christersson J, Isaacs JT, Leanderson T Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol. Cancer, 2010-05-17;9(0):107. 2010-05-17 [PMID: 20470445] (Human)		Human
Pitteri SJ, JeBailey L, Faca VM, Thorpe JD, Silva MA, Ireton RC, Horton MB, Wang H, Pruitt LC, Zhang Q, Cheng KH, Urban N, Hanash SM, Dinulescu DM Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. PLoS ONE, 2009-11-19;4(11):e7916. 2009-11-19 [PMID: 19936259] (Human)		Human
Estrogen regulation of thrombospondin-1 in human breast cancer cells. Int. J. Cancer, 2009-09-01;125(0):1045. 2009-09-01 [PMID: 19391135] (Human)		Human
Oh JY, Kim MK, Shin MS, Wee WR, Lee JH Cytokine secretion by human mesenchymal stem cells cocultured with damaged corneal epithelial cells. Cytokine, 2009-02-14;46(1):100-3. 2009-02-14 [PMID: 19223198] (Human)		Human
Show All 38 Publications. Collapse Publications.

Array DTSP10

• Thrombospondin-1 Antibodies
• Thrombospondin-1 ELISA Kits
• Thrombospondin-1 Lysate
• Thrombospondin-1 Protein
• Thrombospondin-1 Proteins and Enzymes
• Thrombospondin-1 ELISAs