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HSD11B2 Antibody

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Western Blot: HSD11B2 Antibody [NBP2-37898] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10Lane 2: Human Kidney tissue
Western Blot: HSD11B2 Antibody [NBP2-37898] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10Lane 2: Human Kidney tissue
Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP2-37898] - Staining of human rectum.
Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP2-37898] - Staining of human kidney shows high expression.
Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP2-37898] - Staining of human liver shows low expression as expected.
Orthogonal Strategies: Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP2-37898] - Staining in human kidney and liver tissues using anti-HSD11B2 antibody. Corresponding HSD11B2 RNA-seq data are presented for ...read more
Independent Antibodies: Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP2-37898] - Staining of human kidney, liver, lymph node and rectum using Anti-HSD11B2 antibody NBP2-37898 (A) shows similar protein ...read more
Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP2-37898] - Staining of human lymph node.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
 

Independent Antibodies

      

Orthogonal Strategies

  

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HSD11B2 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: GDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLR
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HSD11B2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
  • Western Blot 0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
HSD11B2 Protein (NBP2-37898PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (84%), Rat (89%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for HSD11B2 Antibody

  • 11 betaHSD2
  • 11 beta-HSD2
  • AME
  • corticosteroid 11-beta-dehydrogenase isozyme 2,11-beta-HSD2
  • EC 1.1.1
  • EC 1.1.1.-
  • HSD11B2
  • HSD11KAME1
  • HSD2,11-DH2
  • hydroxysteroid (11-beta) dehydrogenase 2
  • NAD-dependent 11-beta-hydroxysteroid dehydrogenase
  • SDR9C3
  • short chain dehydrogenase/reductase family 9C member 3,11-beta-hydroxysteroid dehydrogenase type 2

Background

HSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. The protein modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME). AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol HSD11B2
Uniprot