MMP-12 Antibody (SR03-23)

Human macrophage elastase (MMP-12) is a member of the family of matrix metalloproteinases (MMPs) that plays, like other members of the family, an important role in inflammatory processes contributing to tissue remodeling and destruction. In particular, a prominent role of MMP-12 in the destruction of elastin in the lung alveolar wall and the pathogenesis of emphysema has been suggested. It is therefore an attractive therapeutic target (1). MMP-12) expressed mainly in alveolar macrophages has been identified in the mouse lung as the main destructive agent associated with cigarette smoking, which gives rise to emphysema, both directly via elastin degradation and indirectly by disturbing the proteinase/antiproteinase balance via inactivation of the alpha1-proteinase inhibitor (alpha1-PI), the antagonist of the leukocyte elastase (2). Because elastin represents a critical component of aortic wall structure and a matrix substrate for metalloelastases, MMP-12 may have a direct and singular role in the pathogenesis of aortic aneurysms (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 4 applications: IHC, IHC-Fr, IHC-P, WB.

Showing Publications 1 - 9 of 9.

Publications using NBP2-67344	Applications	Species
Wu W, Sarhadi M, song X et al. Liver X receptors in the lung, a link between cigarette smoke and lung cancer Research Square 2022-12-16 (IHC, Mouse)	IHC	Mouse
Thomas Lamb, Gagandeep Kaur, Irfan Rahman Tobacco-derived and tobacco-free nicotine cause differential inflammatory cell influx and MMP-9 in mouse lung Respiratory Research 2024-01-23 [PMID: 38254111]
Wu W, Sarhadi M, Song X et al. Liver X receptors and estrogen receptor ?, two players in a rare subtype of NSCLC International journal of biological sciences 2023-05-29 [PMID: 37324952] (IHC-P, Mouse) Details: Mouse lung	IHC-P	Mouse
Zhu X, Schrader JM, Irizarry BA et al. Impact of A beta 40 and A beta 42 Fibrils on the Transcriptome of Primary Astrocytes and Microglia Biomedicines 2022-11-19 [PMID: 36428550] (IHC-Fr, Rat) Details: Fifteen-month-old rTgF344-AD rat brain sections, dilution used 1:200	IHC-Fr	Rat
Witayavanitkul N, Werawatganon D, Chayanupatkul M et al. Genistein and exercise treatment reduced NASH related HDAC3, IL-13 and MMP-12 expressions in ovariectomized rats fed with high fat high fructose diet J Tradit Complement Med 2021-11-12 [PMID: 34765514]
Kaur G, Sundar I, Rahman I p16-3MR: A Novel Model to Study Cellular Senescence in Cigarette Smoke-Induced Lung Injuries International Journal of Molecular Sciences 2021-05-03 [PMID: 34063608] (WB, Mouse)	WB	Mouse
Qixin Wang, Isaac K. Sundar, Joseph H. Lucas, Thivanka Muthumalage, Irfan Rahman Molecular clock REV-ERB alpha regulates cigarette smoke–induced pulmonary inflammation and epithelial-mesenchymal transition JCI Insight 2021-06-22 [PMID: 34014841]
Wang Q, Sundar I, Li D et al. E-cigarette-Induced Pulmonary Inflammation and Dysregulated Repair are Mediated by nAChR ?7 Receptor: Role of nAChR ?7 in ACE2 Covid-19 receptor regulation Research Square 2022-11-07 [PMID: 32702718]
Wang Q, Sundar IK, Li D et al. E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR alpha 7 receptor: role of nAChR alpha 7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation Respir. Res. 2020-06-18 [PMID: 32552811] (WB, Mouse) Details: Citation using the Alexa Fluor 488 format of this antibody.	WB	Mouse

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	IHC-P	Human	09/30/2024	View Summary Application Immunohistochemistry-Paraffin Sample Tested Breast cancer tissue Species Human Lot H00816

Array NBP2-67344

• MMP-12 Antibodies
• MMP-12 ELISA Kits
• MMP-12 Kit
• MMP-12 Proteins and Enzymes