hnRNP A2B1 Antibody (DP3B3) - BSA Free

RNA polymerase II transcripts in the nucleus are in complex with several different proteins called heterogeneous nuclear ribonucleoproteins (hnRNPs). These proteins act in biological activities such as transcription, pre-mRNA processing, cytoplasmic mRNA ranslation, and turnover.2. hnRNPs can be isolated either by immunoprecipitation or by sucrose gradient fractionation of cell extracts. Isolated hnRNPs consist of protein groups named A to U and many of these protein groups consist of more than one isoform.3 The major steadystate proteins of the isolated hnRNP complex are the A1, A2, B1, B2, C1, and C2 with a range of molecular weights (34-43 kDa).3 hnRNP-A2/B1 proteins are located in the nucleus of most tissues cells; however, the hnRNP-A2 protein is found also in the cytoplasm of skin and esophagus cells. In rat brain, hnRNP-A2/B1 proteins are found in neurons in the cerebral cortices, hippocampal formation, olfactory regions, caudate-putamin, and the supraoptic ucleus of the hypothalamus.4 Expression of hnRNP-A2/B1 proteins was found also in lung development and its over expression correlated with lung cancer.5

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 6 applications: Chemotaxis, ICC/IF, IP, KD, KO, WB.

Showing Publications 1 - 10 of 10.

Publications using NB120-6102	Applications	Species
Douglas M. McLaurin, Sara K. Tucker, Michael D. Hebert Coilin mediates m 6 A RNA methylation through phosphorylation of METTL3 Biology Open 2023-12-15 [PMID: 38050869]
Vierbuchen T, Agarwal S, Johnson JL et al. The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2 Proceedings of the National Academy of Sciences of the United States of America 2023-01-03 [PMID: 36577072]
Erdos E, Divoux A, Sandor K et al. Unique role for lncRNA HOTAIR in defining depot-specific gene expression patterns in human adipose-derived stem cells Genes & Development 2022-05-01 [PMID: 35618313]
Bijlard M, Klunder B, de Jonge JC et al. Transcriptional expression of MBP in oligodendrocytes depends on functional syntaxin 4; a potential correlation with autocrine signalling. Mol. Cell. Biol. 2014-12-15 [PMID: 25512606] (ICC/IF, Rat) Details: hnRNA A2B1 antibody was used for Immunocytochemical analysis of oligodendrocyte progenitor cells (OPCs), fixed in 4% PFA then permeabilized with 0.1% Triton X-100 for 30 min (FIG 6).	ICC/IF	Rat
Halbert D, Domenyuk V, Spetzler D et al. Aptamers and uses thereof United States Patent Application US 9958448 B2 2018-01-01
Porman AM, Roberts JT, Duncan ED et al. A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells PLoS biology 2022-11-28 [PMID: 36441764] (WB, Human)	WB	Human
Abakir A, Giles TC, Cristini A N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells Nat. Genet. 2019-12-16 [PMID: 31844323] (IP, KD, Chemotaxis, KO, Mouse)	IP, KD, Chemotaxis, KO	Mouse
Nguyen E D, Balas M M et al. Global profiling of hnRNP A2/B1-RNA binding on chromatin highlights LncRNA interactions. RNA Biol 2018-06-26 [PMID: 29938567] (IP, Human)	IP	Human
Meredith E K, Balas M M et al. An RNA matchmaker protein regulates the activity of the long noncoding RNA HOTAIR. RNA 2016-01-07 [PMID: 27146324] (WB, Human)	WB	Human
Hou VC, Lersch R, Gee SL et al. Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch. EMBO J. 2002-11-15 [PMID: 12426391] (WB, Mouse)	WB	Mouse

Array NB120-6102

• hnRNP A2B1 Antibodies
• hnRNP A2B1 ELISA Kits
• hnRNP A2B1 Lysate
• hnRNP A2B1 Proteins