GR/NR3C1 Antibody (BuGR2) [Alexa Fluor® 647]

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the glucocoticoid receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain glucocorticoid receptor. The corresponding gene for the glucocorticoid receptor is NR3C1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: FLOW, ICC/IF.

Showing Publications 1 - 3 of 3.

Publications using NB300-731AF647	Applications	Species
X Zhao, T Peng, X Cao, Y Hou, R Li, T Han, Z Fan, M Zhao, Y Chang, H Chen, C Li, X Huang In�vivo G-CSF treatment activates the GR-SOCS1 axis to suppress IFN-gamma secretion by natural killer cells Cell Reports, 2022-09-13;40(11):111342. 2022-09-13 [PMID: 36103837]
Adams RCM, Smith C. In utero Exposure to Maternal Chronic Inflammation Transfers a Pro-Inflammatory Profile to Generation F2 via Sex-Specific Mechanisms Front Immunol. [PMID: 32117231] (ICC/IF, Mouse)	ICC/IF	Mouse
Adams R, Smith C Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny Mediators of Inflammation Aug 25 2019 [PMID: 31582905] (Flow, Mouse) Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny. Mediators Inflamm. 2019-08-25 [PMID: 31582905] (FLOW, Mouse) Details: Citation using the Alexa Fluor 647 version of this antibody.	FLOW	Mouse

Array NB300-731AF647

• GR/NR3C1 Antibodies
• GR/NR3C1 ELISA Kits
• GR/NR3C1 Lysates
• GR/NR3C1 Protein