Follistatin Antibody (85918) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an N-terminal atypical TGF binding domain, three Follistatin domains that contain EGF-like and kazal-like motifs, and a highly acidic C-terminal tail. The first Follistatin domain (FS1) contains a heparin binding site, while FS1 and FS2 are most critical for activin binding and neutralization (3, 4). In addition to activin, Follistatin regulates bioavailability of many non-TGF-beta members of the TGF-beta superfamily, such as BMP6, BMP7 and myostatin (5). It also regulates hematopoietic stem cell adhesion to fibronectin via FS2, and binds angiogenin via FS2 and FS3 (6, 7). Some Follistatin binding partners will also bind Follistatin-like proteins such as FSL-3 (3, 5, 6). Of three Follistatin isoforms, the full-length mature Follistatin (FST315) is the most abundant and the sole form in plasma, but has lower binding affinity for both activins and heparins than alternative isoforms (5, 8, 9). The acidic tail is missing in the splice variant FST288 which shows the highest affinity for activins, while a partial tail exists in the proteolytically produced FST303, which shows intermediate activin affinity (5, 8, 9). FST315 shares 98% aa identity with mouse, rat, equine and ovine FST, 99% with porcine and 97% with bovine FST. Genetic deletion of Follistatin in mice, or expression of only the FST288 form, is perinatally lethal due to defects of lung, skin and musculoskeletal system (10). Expression of only the FST315 isoform allows survival, with defects in vascularization and female fertility (10).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Canine, Goat.

We have publications tested in 5 applications: ICC, IHC, IHC-Fr, IHC-P, Neutralization.

Showing Publications 1 - 10 of 10.

Publications using MAB669	Applications	Species
Sasaki M, Hara T, Wang JX et al. Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis bioRxiv : the preprint server for biology 3/28/2023 [PMID: 37034590]
S Janik, C Bekos, P Hacker, T Raunegger, AI Schiefer, L Müllauer, C Veraar, B Dome, W Klepetko, HJ Ankersmit, B Moser Follistatin impacts Tumor Angiogenesis and Outcome in Thymic Epithelial Tumors Sci Rep, 2019-11-22;9(1):17359. 2019-11-22 [PMID: 31757999] (IHC, Human)	IHC	Human
W Wu, XL Wu, YQ Ji, Z Gao Differentiation of nestin?negative human hair follicle outer root sheath cells into neurons in�vitro Mol Med Rep, 2017-05-16;0(0):. 2017-05-16 [PMID: 28534946] (ICC, Human)	ICC	Human
Jiang , Ming, Ku , Wei-Yao, Zhou , Zhongren, Dellon , Evan S, Falk , Gary W, Nakagawa , Hiroshi, Wang , Mei-Lun, Liu , Kuancan, Wang , Jun, Katzka , David A, Peters , Jeffrey, Lan , Xiaopeng, Que , Jianwen BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis. J Clin Invest, 2015-03-16;125(4):1557-68. 2015-03-16 [PMID: 25774506] (IHC, Mouse)	IHC	Mouse
Gao X, Wei S, Lai K Nucleolar follistatin promotes cancer cell survival under glucose-deprived conditions through inhibiting cellular rRNA synthesis. J. Biol. Chem., 2010-09-15;285(47):36857-64. 2010-09-15 [PMID: 20843798] (ICC, Human)	ICC	Human
Kobayashi T, Iwasaki T, Amagai M Canine follicle stem cell candidates reside in the bulge and share characteristic features with human bulge cells. J. Invest. Dermatol., 2010-04-01;130(8):1988-95. 2010-04-01 [PMID: 20357816] (IHC-Fr, Canine)	IHC-Fr	Canine
O'Neill JP, Velalar CN, Lee DI, Zhang B, Nakanishi T, Tang Y, Selaru F, Ross D, Meltzer SJ, Hussain A Thapsigargin resistance in human prostate cancer cells. Cancer, 2006-08-01;107(3):649-59. 2006-08-01 [PMID: 16770788] (ICC, Human)	ICC	Human
Silva JR, Tharasanit T, Taverne MA, van der Weijden GC, Santos RR, Figueiredo JR, van den Hurk R The activin-follistatin system and in vitro early follicle development in goats. J. Endocrinol., 2006-04-01;189(1):113-25. 2006-04-01 [PMID: 16614386] (IHC-P, Goat)	IHC-P	Goat
Tardif G, Hum D, Pelletier JP, Boileau C, Ranger P, Martel-Pelletier J Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Arthritis Rheum., 2004-08-01;50(8):2521-30. 2004-08-01 [PMID: 15334466] (IHC-P, Human)	IHC-P	Human
Abe Y, Abe T, Aida Y, Hara Y, Maeda K Follistatin restricts bone morphogenetic protein (BMP)-2 action on the differentiation of osteoblasts in fetal rat mandibular cells. J. Bone Miner. Res., 2004-05-03;19(8):1302-7. 2004-05-03 [PMID: 15231018] (Neutralization, Rat)	Neutralization	Rat

Array MAB669

• Follistatin Antibodies
• Follistatin ELISA Kits
• Follistatin Lysates
• Follistatin Proteins
• Follistatin Proteins and Enzymes
• Follistatin ELISAs