Recombinant Human BMP-7 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP-1), is a widely expressed TGF-beta superfamily member with important functions during embryogenesis, in the adult, and in disease (1, 2). Human BMP-7 is synthesized with a 29 amino acid (aa) signal sequence, a 263 aa propeptide, and a 139 aa growth factor domain (3, 4). The growth factor domain of human BMP-7 shares 98% aa sequence identity with mouse and rat BMP-7. The BMP-7 propeptide is cleaved intracellularly but remains in association with the growth factor domain. BMP-7 is subsequently secreted as a tetramer that consists of two propeptides and two disulfide-linked growth factor domains (5, 6). Mature BMP-7 can also form disulfide-linked heterodimers with BMP-2 or BMP-4, complexes that show increased potency and range of activity compared to BMP-7 homodimers (7-9). The presence of the propeptides in the BMP-7 tetramer does not diminish the bioactivity of the growth factor domains (6). Secreted BMP-7 is immobilized in the extracellular matrix as a result of interactions between the propeptide and matrix Fibrillin (5). BMP-7 exerts its biological effects through the type 2 receptors Activin RIIA, Activin RIIB, and BMPR-II and the type 1 receptors Activin RIA, BMPR-IA, and BMPR-IB (2, 6). BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (10, 11), inhibits the branching of prostate epithelium (12), and antagonizes epithelial-mesenchymal transition (EMT) (13-15). In pathological conditions, BMP-7 inhibits tumor growth and metastasis (14), ameliorates fibrotic damage in nephritis (13), and promotes neuroregeneration following brain ischemia (16).

We have publications tested in 8 confirmed species: Human, Mouse, Rat, Bovine, Chicken, Porcine, Xenopus, Zebrafish.

We have publications tested in 9 applications: Binding Assay, Bioassay, Cell Culture, ELISA (Capture), ELISA Capture, ELISA Standard, In Vivo, Surface Plasmon Resonance, Surface Plasmon Resonance (SPR.

Showing Publications 1 - 10 of 94. Show All 94 Publications. Collapse Publications.

Publications using 354-BP	Applications	Species
Tatsumi, K;Wada, H;Hasegawa, S;Asukai, K;Nagata, S;Ekawa, T;Akazawa, T;Mizote, Y;Okumura, S;Okamura, R;Ohue, M;Obama, K;Tahara, H; Prediction for oxaliplatin-induced liver injury using patient-derived liver organoids Cancer medicine 2024-02-01 [PMID: 38400666] (Bioassay, Human)	Bioassay	Human
Nagel, S;Haake, J;Pommerenke, C;Meyer, C;MacLeod, RAF; Establishment of the Myeloid TBX-Code Reveals Aberrant Expression of T-Box Gene TBX1 in Chronic Myeloid Leukemia International journal of molecular sciences 2023-12-19 [PMID: 38203204] (Bioassay, Human)	Bioassay	Human
S Abdul Maje, H Dunzendorf, J Weiner, JT Heiker, W Kiess, A Körner, K Landgraf COBL, MKX and MYOC Are Potential Regulators of Brown Adipose Tissue Development Associated with Obesity-Related Metabolic Dysfunction in Children International Journal of Molecular Sciences, 2023-02-04;24(4):. 2023-02-04 [PMID: 36834493] (Bioassay, Mouse)	Bioassay	Mouse
R Oude Egber, HM Zegelaar, N El Boujnou, EMM Versteeg, WF Daamen, R Brock Biomaterial-Mediated Protein Expression Induced by Peptide-mRNA Nanoparticles Embedded in Lyophilized Collagen Scaffolds Pharmaceutics, 2022-08-02;14(8):. 2022-08-02 [PMID: 36015245] (ELISA Standard, Mouse)	ELISA Standard	Mouse
T Hayashi, M Asakura, M Kawase, M Matsubara, Y Uematsu, A Mieki, T Kawai Bone Tissue Engineering in Rat Calvarial Defects Using Induced Bone-like Tissue by rhBMPs from Immature Muscular Tissues In Vitro International Journal of Molecular Sciences, 2022-06-22;23(13):. 2022-06-22 [PMID: 35805943] (Bioassay, Rat)	Bioassay	Rat
BY Kim, SH Choi, JY Kim, J Ko, JI Yook, HS Kim, EJ Lee, DO Kikkawa, JS Yoon Potential Therapeutic Role of Bone Morphogenic Protein 7 (BMP7) in the Pathogenesis of Graves' Orbitopathy Investigative Ophthalmology & Visual Science, 2022-06-01;63(6):7. 2022-06-01 [PMID: 35671049] (Bioassay, Human)	Bioassay	Human
J Jeong, TH Kim, M Kim, YK Jung, KS Kim, S Shim, H Jang, WI Jang, SB Lee, D Choi Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids Biology, 2022-03-23;11(4):. 2022-03-23 [PMID: 35453693] (Bioassay, Human)	Bioassay	Human
S Minatoguch, S Saito, K Furuhashi, Y Sawa, M Okazaki, Y Shimamura, AB Kaihan, Y Hashimoto, Y Yasuda, A Hara, Y Mizutani, R Ando, N Kato, T Ishimoto, N Tsuboi, N Esaki, M Matsuyama, Y Shiraki, H Kobayashi, N Asai, A Enomoto, S Maruyama A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts Scientific Reports, 2022-03-30;12(1):5389. 2022-03-30 [PMID: 35354870] (Bioassay, Mouse)	Bioassay	Mouse
J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, R Roverts, D Daviran, LAS Fermin, B Willemsen, M Beukenboom, S Djudjaj, S von Stillf, LE van Eijk, M Mastik, M Bulthuis, WD Dunnen, H van Goor, JL Hillebrand, SH Triana, T Alexandrov, MC Timm, BT van den Be, M van den Br, Q Nlandu, J Heijnert, EMJ Bindels, RM Hoogenboez, F Mooren, C Kuppe, P Miesen, K Grünberg, T Ijzermans, EJ Steenberge, J Czogalla, MF Schreuder, N Sommerdijk, A Akiva, P Boor, VG Puelles, J Floege, TB Huber, COVID Moon, RP van Rij, IG Costa, RK Schneider, B Smeets, R Kramann SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids Cell Stem Cell, 2021-12-25;29(2):217-231.e8. 2021-12-25 [PMID: 35032430] (Bioassay, Human)	Bioassay	Human
Y Soejima, N Iwata, Y Nakano, K Yamamoto, A Suyama, T Nada, F Otsuka Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells International Journal of Molecular Sciences, 2021-10-17;22(20):. 2021-10-17 [PMID: 34681844] (Cell Culture, Human)	Cell Culture	Human
EGJ Ripmeester, MMJ Caron, GGH van den Ak, J Steijns, DAM Surtel, A Cremers, LCW Peeters, LW van Rhijn, TJM Welting BMP7 reduces the fibrocartilage chondrocyte phenotype Scientific Reports, 2021-10-04;11(1):19663. 2021-10-04 [PMID: 34608249] (Bioassay, Human)	Bioassay	Human
R Kumar, AV Grinberg, H Li, TH Kuo, D Sako, L Krishnan, K Liharska, J Li, R Grenha, MC Maguire, SD Briscoe, RS Pearsall, BR Herrin, RNVS Suragani, R Castonguay Functionally diverse heteromeric traps for ligands of the transforming growth factor-beta superfamily Scientific Reports, 2021-09-15;11(1):18341. 2021-09-15 [PMID: 34526551] (Bioassay, Human)	Bioassay	Human
L E, R Lu, J Sun, H Li, W Xu, H Xing, X Wang, T Cheng, S Zhang, X Ma, R Zhang, H Liu Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration Stem Cells International, 2021-08-17;2021(0):4465022. 2021-08-17 [PMID: 34447439] (Bioassay, Human)	Bioassay	Human
T Nakajima, A Nakahata, N Yamada, K Yoshizawa, TM Kato, M Iwasaki, C Zhao, H Kuroki, M Ikeya Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture Nature Communications, 2021-08-18;12(1):5012. 2021-08-18 [PMID: 34408142] (Bioassay, Human)	Bioassay	Human
S Srinivasa, R Garcia-Mar, M Torriani, KV Fitch, AR Carlson, CR Kahn, SK Grinspoon Altered pattern of circulating miRNAs in HIV lipodystrophy perturb key adipose differentiation and inflammation pathways JCI Insight, 2021-09-22;0(0):. 2021-09-22 [PMID: 34383714] (Bioassay, Human)	Bioassay	Human
L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State Cell Stem Cell, 2020-08-11;0(0):. 2020-08-11 [PMID: 32783886] (Bioassay, Human)	Bioassay	Human
EGJ Ripmeester, MMJ Caron, GGH van den Ak, DAM Surtel, A Cremers, P Balaskas, P Dyer, BAC Housmans, A Chabronova, A Smagul, Y Fang, LW van Rhijn, MJ Peffers, TJM Welting Impaired chondrocyte U3 snoRNA expression in osteoarthritis impacts the chondrocyte protein translation apparatus Sci Rep, 2020-08-10;10(1):13426. 2020-08-10 [PMID: 32778764] (Bioassay, Human)	Bioassay	Human
K Wei, I Korsunsky, JL Marshall, A Gao, GFM Watts, T Major, AP Croft, J Watts, PE Blazar, JK Lange, TS Thornhill, A Filer, K Raza, LT Donlin, CW Siebel, CD Buckley, S Raychaudhu, MB Brenner Notch signalling drives synovial fibroblast identity and arthritis pathology Nature, 2020-04-22;582(7811):259-264. 2020-04-22 [PMID: 32499639] (Bioassay, Human)	Bioassay	Human
AM Singh, L Zhang, J Avery, A Yin, Y Du, H Wang, Z Li, H Fu, H Yin, S Dalton Human beige adipocytes for drug discovery and cell therapy in metabolic diseases Nat Commun, 2020-06-02;11(1):2758. 2020-06-02 [PMID: 32488069] (Bioassay, Human)	Bioassay	Human
Kumar Gupta A, Sarkar P, Wertheim J, Pan X, Carroll T, Oxburgh L Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids. Commun Biol, 2020-05-11;3(1):231. 2020-05-11 [PMID: 32393756] (Bioassay, Human)	Bioassay	Human
A Krouwels, JD Iljas, AHM Kragten, WJA Dhert, FC Öner, MA Tryfonidou, LB Creemers Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration Int J Mol Sci, 2020-04-14;21(8):. 2020-04-14 [PMID: 32295299] (Bioassay, Human)	Bioassay	Human
H Tsujimoto, T Kasahara, SI Sueta, T Araoka, S Sakamoto, C Okada, SI Mae, T Nakajima, N Okamoto, D Taura, M Nasu, T Shimizu, M Ryosaka, Z Li, M Sone, M Ikeya, A Watanabe, K Osafune A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells Cell Rep, 2020-04-07;31(1):107476. 2020-04-07 [PMID: 32268094] (Bioassay, Human)	Bioassay	Human
M Ali, F Kabir, JJ Thomson, Y Ma, C Qiu, M Delannoy, SY Khan, SA Riazuddin Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies Sci Rep, 2019-12-06;9(1):18552. 2019-12-06 [PMID: 31811247] (Bioassay, Human)	Bioassay	Human
D Seo, SM Jung, JS Park, J Lee, J Ha, M Kim, SH Park The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway EBioMedicine, 2019-11-01;49(0):55-71. 2019-11-01 [PMID: 31685442] (Cell Culture, Human)	Cell Culture	Human
M Omi, V Kaartinen, Y Mishina Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD signaling pathway J. Biol. Chem., 2019-10-16;0(0):. 2019-10-16 [PMID: 31619522] (Bioassay, Mouse)	Bioassay	Mouse
T Kamperman, M Koerselman, C Kelder, J Hendriks, JF Crispim, X de Peuter, PJ Dijkstra, M Karperien, J Leijten Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs Nat Commun, 2019-09-25;10(1):4347. 2019-09-25 [PMID: 31554812] (ELISA Capture, Surface Plasmon Resonance (SPR, Human)	ELISA Capture, Surface Plasmon Resonance (SPR	Human
M Huang, J Tailor, Q Zhen, AH Gillmor, ML Miller, H Weishaupt, J Chen, T Zheng, EK Nash, LK McHenry, Z An, F Ye, Y Takashima, J Clarke, H Ayetey, FMG Cavalli, B Luu, BS Moriarity, S Ilkhanizad, L Chavez, C Yu, KM Kurian, T Magnaldo, N Sevenet, P Koch, SM Pollard, P Dirks, MP Snyder, DA Largaespad, YJ Cho, JJ Phillips, FJ Swartling, AS Morrissy, M Kool, SM Pfister, MD Taylor, A Smith, WA Weiss Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis Cell Stem Cell, 2019-06-13;0(0):. 2019-06-13 [PMID: 31204176] (Bioassay, Human)	Bioassay	Human
S Muller, I Ader, J Creff, H Leménager, P Achard, L Casteilla, L Sensebé, A Carrière, F Deschaseau Human adipose stromal-vascular fraction self-organizes to form vascularized adipose tissue in 3D cultures Sci Rep, 2019-05-10;9(1):7250. 2019-05-10 [PMID: 31076601] (Human)		Human
Á Klusóczki, Z Veréb, A Vámos, P Fischer-Po, M Wabitsch, Z Bacso, L Fésüs, E Kristóf Differentiating SGBS adipocytes respond to PPAR? stimulation, irisin and BMP7 by functional browning and beige characteristics Sci Rep, 2019-04-09;9(1):5823. 2019-04-09 [PMID: 30967578] (Bioassay, Human)	Bioassay	Human
MJ Harms, Q Li, S Lee, C Zhang, B Kull, S Hallen, A Thorell, I Alexanders, CE Hagberg, XR Peng, A Mardinoglu, KL Spalding, J Boucher Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes Cell Rep, 2019-04-02;27(1):213-225.e5. 2019-04-02 [PMID: 30943403] (Bioassay, Human)	Bioassay	Human
WKW Ho, L Freem, D Zhao, KJ Painter, TE Woolley, EA Gaffney, MJ McGrew, A Tzika, MC Milinkovit, P Schneider, A Drusko, F Matthäus, JD Glover, KL Wells, JA Johansson, MG Davey, HM Sang, M Clinton, DJ Headon Feather arrays are patterned by interacting signalling and cell density waves PLoS Biol., 2019-02-21;17(2):e3000132. 2019-02-21 [PMID: 30789897] (Bioassay, Chicken)	Bioassay	Chicken
M Kijewska, C Viski, F Turrell, A Fitzpatric, A van Weverw, Q Gao, M Iravani, CM Isacke Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain Breast Cancer Res., 2019-01-14;21(1):4. 2019-01-14 [PMID: 30642388] (Bioassay, Mouse)	Bioassay	Mouse
CC Weng, PY Ding, YH Liu, JR Hawse, M Subramania, CC Wu, YC Lin, CY Chen, WC Hung, KH Cheng Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis Oncogene, 2018-11-22;0(0):. 2018-11-22 [PMID: 30467381] (Bioassay, Mouse)	Bioassay	Mouse
X Huang, L Zhong, JN Post, M Karperien Co-treatment of TGF-?3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments Sci Rep, 2018-07-06;8(1):10251. 2018-07-06 [PMID: 29980690] (Bioassay, Human)	Bioassay	Human
C Chen, GC Bai, HL Jin, K Lei, KX Li Local injection of bone morphogenetic protein 7 promotes neuronal regeneration and motor function recovery after acute spinal cord injury Neural Regen Res, 2018-06-01;13(6):1054-1060. 2018-06-01 [PMID: 29926833] (In Vivo, Rat)	In Vivo	Rat
K Hino, K Horigome, M Nishio, S Komura, S Nagata, C Zhao, Y Jin, K Kawakami, Y Yamada, A Ohta, J Toguchida, M Ikeya Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva J. Clin. Invest., 2017-07-31;0(0):. 2017-07-31 [PMID: 28758906] (In Vivo, Mouse)	In Vivo	Mouse
C Sallon, I Callebaut, I Boulay, J Fontaine, D Logeart-Av, C Henriquet, M Pugnière, X Cayla, P Monget, G Harichaux, V Labas, S Canepa, C Taragnat Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells J. Biol. Chem., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747434] (Bioassay, Mouse)	Bioassay	Mouse
P Wongwitwic, J Kaewsricha Osteogenic differentiation of mesenchymal stem cells is impaired by bone morphogenetic protein 7 Adv Med Sci, 2017-05-11;62(2):266-272. 2017-05-11 [PMID: 28501726] (Bioassay, Rat)	Bioassay	Rat
LK Bollum, K Huse, MP Oksvold, B Bai, VI Hilden, L Forfang, SO Yoon, S Wälchli, EB Smeland, JH Myklebust BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-? receptor type I ALK5 PLoS ONE, 2017-05-10;12(5):e0177188. 2017-05-10 [PMID: 28489883] (Bioassay, Human)	Bioassay	Human
E Raja, A Komuro, R Tanabe, S Sakai, Y Ino, N Saito, T Todo, M Morikawa, H Aburatani, D Koinuma, C Iwata, K Miyazono Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells Oncogene, 2017-05-01;0(0):. 2017-05-01 [PMID: 28459464] (Bioassay, Human)	Bioassay	Human
DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney Supraphysiological levels of GDF11 induce striated muscle atrophy EMBO Mol Med, 2017-04-01;0(0):. 2017-04-01 [PMID: 28270449] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
A Shiraishi, K Muguruma, Y Sasai Generation of thalamic neurons from mouse embryonic stem cells Development, 2017-02-20;0(0):. 2017-02-20 [PMID: 28219951] (Bioassay, Mouse)	Bioassay	Mouse
T Chattopadh, RR Singh, S Gupta, A Surolia Bone morphogenetic protein-7 (BMP-7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway Biofactors, 2017-02-10;0(0):. 2017-02-10 [PMID: 28186649] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication PLoS ONE, 2016-12-15;11(12):e0168334. 2016-12-15 [PMID: 27977771] (Bioassay, Human)	Bioassay	Human
Mélanie Gadelorge Clinical-scale expansion of Adipose derived Stromal Cells starting from Stromal Vascular Fraction in a single-use bioreactor: Proof of concept for autologous applications J Tissue Eng Regen Med, 2017-05-12;0(0):. 2017-05-12 [PMID: 27943660] (Bioassay, Human)	Bioassay	Human
Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis PLoS Genet, 2016-12-06;12(12):e1006474. 2016-12-06 [PMID: 27923061] (Bioassay, Mouse)	Bioassay	Mouse
G Picarda, C Chéneau, JM Humbert, G Bériou, P Pilet, J Martin, F Duteille, P Perrot, F Bellier-Wa, M Heslan, F Haspot, F Guillon, R Josien, FA Halary Functional Langerinhigh-Expressing Langerhans-like Cells Can Arise from CD14highCD16- Human Blood Monocytes in Serum-Free Condition J Immunol, 2016-03-25;0(0):. 2016-03-25 [PMID: 27016604] (Bioassay, Human)	Bioassay	Human
Kjartansdottir K, Reda A, Panula S, Day K, Hultenby K, Soder O, Hovatta O, Stukenborg J A Combination of Culture Conditions and Gene Expression Analysis Can Be Used to Investigate and Predict hES Cell Differentiation Potential towards Male Gonadal Cells. PLoS ONE, 2015-12-02;10(12):e0144029. 2015-12-02 [PMID: 26630562] (Bioassay, Human)	Bioassay	Human
Handorf A, Chamberlain C, Li W Endogenously produced Indian Hedgehog regulates TGFbeta-driven chondrogenesis of human bone marrow stromal/stem cells. Stem Cells Dev, 2015-01-26;24(8):995-1007. 2015-01-26 [PMID: 25519748] (Bioassay, Human)	Bioassay	Human
Moisan A, Lee Y, Zhang J, Hudak C, Meyer C, Prummer M, Zoffmann S, Truong H, Ebeling M, Kiialainen A, Gerard R, Xia F, Schinzel R, Amrein K, Cowan C White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol, 2014-12-08;17(1):57-67. 2014-12-08 [PMID: 25487280] (Bioassay, Human)	Bioassay	Human
Thiede B, Mann Z, Chang W, Ku Y, Son Y, Lovett M, Kelley M, Corwin J Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea. Nat Commun, 2014-05-20;5(0):3840. 2014-05-20 [PMID: 24845860] (Bioassay, Chicken)	Bioassay	Chicken
Mann Z, Thiede B, Chang W, Shin J, May-Simera H, Lovett M, Corwin J, Kelley M A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear. Nat Commun, 2014-05-20;5(0):3839. 2014-05-20 [PMID: 24845721] (Bioassay, Chicken)	Bioassay	Chicken
Jin , Qiming, Giannobile , William SDF-1 enhances wound healing of critical-sized calvarial defects beyond self-repair capacity. PLoS ONE, 2014-05-06;9(5):e97035. 2014-05-06 [PMID: 24800841] (Bioassay, Mouse)	Bioassay	Mouse
Ge D, Zhang Q, Zabaleta J, Zhang Q, Liu S, Reiser B, Bunnell B, Braun S, O'Brien M, Savoie F, You Z Doublecortin may play a role in defining chondrocyte phenotype. Int J Mol Sci, 2014-04-22;15(4):6941-60. 2014-04-22 [PMID: 24758934] (Bioassay, Human)	Bioassay	Human
Omori , Akiko, Miyagawa , Shinichi, Ogino , Yukiko, Harada , Masayo, Ishii , Kenichir, Sugimura , Yoshiki, Ogino , Hajime, Nakagata , Naomi, Yamada , Gen Essential roles of epithelial bone morphogenetic protein signaling during prostatic development. Endocrinology, 2014-04-14;155(7):2534-44. 2014-04-14 [PMID: 24731097] (Bioassay, Human)	Bioassay	Human
Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton K, Tyminski E, Paradis T, Zhang Y, Jones J, von Schack D, Brown C, Milos P, Coyle A, Tremblay F, Martinez R Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6. PLoS ONE, 2014-03-21;9(3):e92608. 2014-03-21 [PMID: 24658703] (Bioassay, Mouse)	Bioassay	Mouse
Yamada , Sachiko, Nakamura , Jin, Asada , Misako, Takase , Masayuki, Matsusaka , Taiji, Iguchi , Taku, Yamada , Ryo, Tanaka , Mari, Higashi , Atsuko Y, Okuda , Tomohiko, Asada , Nariaki, Fukatsu , Atsushi, Kawachi , Hiroshi, Graf , Daniel, Muso , Eri, Kita , Toru, Kimura , Takeshi, Pastan , Ira, Economides , Aris N, Yanagita , Motoko Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury. PLoS ONE, 2014-02-25;9(2):e89135. 2014-02-25 [PMID: 24586548] (Bioassay, Mouse)	Bioassay	Mouse
Goyal , Akshi, Chavez , Shawn L, Reijo Pera , Renee A Generation of human induced pluripotent stem cells using epigenetic regulators reveals a germ cell-like identity in partially reprogrammed colonies. PLoS ONE, 2013-12-12;8(12):e82838. 2013-12-12 [PMID: 24349377] (Cell Culture, Human)	Cell Culture	Human
Xue , Ruidan, Wan , Yun, Zhang , Shuo, Zhang , Qiongyue, Ye , Hongying, Li , Yiming Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes. Am J Physiol Endocrinol Metab, 2013-12-17;306(4):E363-72. 2013-12-17 [PMID: 24347060] (Bioassay, Human)	Bioassay	Human
Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, Hollander A Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis. Stem Cells Dev, 2013-12-04;23(5):541-54. 2013-12-04 [PMID: 24172175] (Bioassay, Human)	Bioassay	Human
Long , Jianyin, Badal , Shawn S, Wang , Yin, Chang , Benny H, Rodriguez , Antony, Danesh , Farhad R MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney. J Biol Chem, 2013-10-25;288(51):36202-14. 2013-10-25 [PMID: 24163368] (Bioassay, Human)	Bioassay	Human
Lorda-Diez C, Montero J, Choe S, Garcia-Porrero J, Hurle J Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro. J Bone Miner Res, 2014-03-01;29(3):735-48. 2014-03-01 [PMID: 24038612] (Bioassay, Human)	Bioassay	Human
Deschaseaux F, Gaillard J, Langonne A, Chauveau C, Naji A, Bouacida A, Rosset P, Heymann D, De Pinieux G, Rouas-Freiss N, Sensebe L Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue. FASEB J, 2013-04-16;27(8):2977-87. 2013-04-16 [PMID: 23592762] (Bioassay, Human)	Bioassay	Human
Glister C, Satchell L, Bathgate R, Wade J, Dai Y, Ivell R, Anand-Ivell R, Rodgers R, Knight P Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proc Natl Acad Sci U S A, 2013-03-25;110(15):E1426-35. 2013-03-25 [PMID: 23530236] (Bioassay, Bovine)	Bioassay	Bovine
Okumura N, Kay E, Nakahara M, Hamuro J, Kinoshita S, Koizumi N Inhibition of TGF-beta signaling enables human corneal endothelial cell expansion in vitro for use in regenerative medicine. PLoS ONE, 2013-02-25;8(2):e58000. 2013-02-25 [PMID: 23451286] (Bioassay, Human)	Bioassay	Human
Narayanan , Karthike, Schumacher , Karl M, Tasnim , Farah, Kandasamy , Karthike, Schumacher , Annegret, Ni , Ming, Gao , Shujun, Gopalan , Began, Zink , Daniele, Ying , Jackie Y Human embryonic stem cells differentiate into functional renal proximal tubular-like cells. Kidney Int, 2013-02-06;83(4):593-603. 2013-02-06 [PMID: 23389418] (Bioassay, Human)	Bioassay	Human
Mae , Shin-Ich, Shono , Akemi, Shiota , Fumihiko, Yasuno , Tetsuhik, Kajiwara , Masatosh, Gotoda-Nishimura , Nanaka, Arai , Sayaka, Sato-Otubo , Aiko, Toyoda , Taro, Takahashi , Kazutosh, Nakayama , Naoki, Cowan , Chad A, Aoi , Takashi, Ogawa , Seishi, McMahon , Andrew P, Yamanaka , Shinya, Osafune , Kenji Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun, 2013-01-01;4(0):1367. 2013-01-01 [PMID: 23340407] (Bioassay, Human)	Bioassay	Human
Huse K, Bakkebo M, Walchli S, Oksvold M, Hilden V, Forfang L, Bredahl M, Liestol K, Alizadeh A, Smeland E, Myklebust J Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma. PLoS ONE, 2012-10-01;7(10):e46117. 2012-10-01 [PMID: 23049692] (Bioassay, Human)	Bioassay	Human
Wu , Qifang, Sun , Chia Chi, Lin , Herbert, Babitt , Jodie L Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE, 2012-09-27;7(9):e46307. 2012-09-27 [PMID: 23029472] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
Kim M, Yoon S, Lee S Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion. PLoS ONE, 2012-04-13;7(4):e35100. 2012-04-13 [PMID: 22514712] (Binding Assay, Human)	Binding Assay	Human
Regulation of chemotropic guidance of nerve growth cones by microRNA. Mol Brain, 2011-11-03;4(0):40. 2011-11-03 [PMID: 22051374] (Bioassay, Xenopus)	Bioassay	Xenopus
Mottershead D, Ritter L, Gilchrist R Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15. Mol Hum Reprod, 2011-09-12;18(3):121-8. 2011-09-12 [PMID: 21911477] (Bioassay, Mouse)	Bioassay	Mouse
Huse K, Bakkebo M, Oksvold MP, Forfang L, Hilden VI, Stokke T, Smeland EB, Myklebust JH Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7. Eur. J. Immunol., 2011-10-18;41(11):3135-45. 2011-10-18 [PMID: 21898381] (Bioassay, Human)	Bioassay	Human
Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011-07-07;286(34):30034-46. 2011-07-07 [PMID: 21737454] (Surface Plasmon Resonance, Human, Mouse)	Surface Plasmon Resonance	Human, Mouse
Geens M, Sermon KD Sertoli cell-conditioned medium induces germ cell differentiation in human embryonic stem cells. J. Assist. Reprod. Genet., 2011-02-12;0(0):. 2011-02-12 [PMID: 21318592] (Bioassay, Human)	Bioassay	Human
Hackett TL, Warner SM, Stefanowicz D, Shaheen F, Pechkovsky DV, Murray LA, Argentieri R, Kicic A, Stick SM, Bai TR, Knight DA Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. Am. J. Respir. Crit. Care Med., 2009-04-30;180(2):122-33. 2009-04-30 [PMID: 19406982] (Bioassay, Human)	Bioassay	Human
Little SC, Mullins MC Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat. Cell Biol., 2009-04-19;11(5):637-43. 2009-04-19 [PMID: 19377468] (Bioassay, Zebrafish)	Bioassay	Zebrafish
Herrera B, Inman GJ A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol., 2009-03-19;10(0):20. 2009-03-19 [PMID: 19298647] (Bioassay, Mouse)	Bioassay	Mouse
Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature, 2008-08-21;454(7207):1000-4. 2008-08-21 [PMID: 18719589] (Bioassay, Mouse)	Bioassay	Mouse
Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J. Mol. Biol., 2008-07-02;381(4):1025-39. 2008-07-02 [PMID: 18621057] (ELISA (Capture), Surface Plasmon Resonance, Human)	ELISA (Capture), Surface Plasmon Resonance	Human
Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J. Biol. Chem., 2008-03-13;283(20):13874-88. 2008-03-13 [PMID: 18339631] (Binding Assay, Surface Plasmon Resonance, Human)	Binding Assay, Surface Plasmon Resonance	Human
Lin H, Shabbir A, Molnar M, Yang J, Marion S, Canty JM, Lee T Adenoviral expression of vascular endothelial growth factor splice variants differentially regulate bone marrow-derived mesenchymal stem cells. J. Cell. Physiol., 2008-08-01;216(2):458-68. 2008-08-01 [PMID: 18288639] (Bioassay, Porcine)	Bioassay	Porcine
Shiraki N, Yoshida T, Araki K, Umezawa A, Higuchi Y, Goto H, Kume K, Kume S Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm. Stem Cells, 2008-01-31;26(4):874-85. 2008-01-31 [PMID: 18238854] (Bioassay, Human)	Bioassay	Human
Zilberberg L, ten Dijke P, Sakai L, Rifkin D A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol, 2007-09-19;8(0):41. 2007-09-19 [PMID: 17880711] (Bioassay)	Bioassay
Fuller ML, DeChant AK, Rothstein B, Caprariello A, Wang R, Hall AK, Miller RH Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Ann. Neurol., 2007-09-01;62(3):288-300. 2007-09-01 [PMID: 17696121] (In Vivo, Rat)	In Vivo	Rat
Wen Z, Han L, Bamburg JR, Shim S, Ming GL, Zheng JQ BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J. Cell Biol., 2007-07-02;178(1):107-19. 2007-07-02 [PMID: 17606869] (Bioassay, Xenopus)	Bioassay	Xenopus
Salero E, Hatten ME Differentiation of ES cells into cerebellar neurons. Proc. Natl. Acad. Sci. U.S.A., 2007-02-09;104(8):2997-3002. 2007-02-09 [PMID: 17293457] (Bioassay, Mouse)	Bioassay	Mouse
Kiyono M, Shibuya M Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4. Oncogene, 2006-05-29;25(54):7131-7. 2006-05-29 [PMID: 16732319] (Bioassay, Human)	Bioassay	Human
Maeshima A, Vaughn DA, Choi Y, Nigam SK Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 2006-04-27;295(2):473-85. 2006-04-27 [PMID: 16643884] (Bioassay, Rat)	Bioassay	Rat
Holzschuh J, Wada N, Wada C, Schaffer A, Javidan Y, Tallafuss A, Bally-Cuif L, Schilling TF Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish. Development, 2005-08-01;132(16):3731-42. 2005-08-01 [PMID: 16077092] (In Vivo, Xenopus)	In Vivo	Xenopus
Steinberg Z, Myers C, Heim VM, Lathrop CA, Rebustini IT, Stewart JS, Larsen M, Hoffman MP FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development, 2005-02-16;132(6):1223-34. 2005-02-16 [PMID: 15716343] (Bioassay, Mouse)	Bioassay	Mouse
Peterson RS, Andhare RA, Rousche KT, Knudson W, Wang W, Grossfield JB, Thomas RO, Hollingsworth RE, Knudson CB CD44 modulates Smad1 activation in the BMP-7 signaling pathway. J. Cell Biol., 2004-09-27;166(7):1081-91. 2004-09-27 [PMID: 15452148] (Bioassay, Bovine)	Bioassay	Bovine
Knosp WM, Scott V, Bachinger HP, Stadler HS HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis. Development, 2004-09-01;131(18):4581-92. 2004-09-01 [PMID: 15342482] (In Vivo, Mouse)	In Vivo	Mouse
Jaskoll T, Witcher D, Toreno L, Bringas P, Moon AM, Melnick M FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis. Dev. Biol., 2004-04-15;268(2):457-69. 2004-04-15 [PMID: 15063181] (Bioassay, Mouse)	Bioassay	Mouse
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