Which is your best CXCR4 for immunohistochemistry in paraffin tissues? I would like to detect it in paraffin embedded tissues from human breast cancer samples.

Name: CXCR4 Antibody
Brand: Novus Biologicals
SKU: NB100-56437
Rating: 5 (1 reviews)

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Accepted Answer

CXCR4 antibody (NB100-74396) is our best selling product among all the CXCR4 antibodies and it has been validated for IHC-P in human cervical carcinoma tissue sections. NB100-74396 has been cited in at least 7 research publications. Additionally, here is a list of all of our CXCR4 antibodies that has been verified in IHC-P in human samples.

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, Rt, ShSpecies Glossary
Applications	WB, ICC/IF, IHC, KD
Clonality	Polyclonal
Host	Rabbit
Conjugate	Unconjugated
Concentration	1.0 mg/ml

Catalog# & Formulation	Size	Price
Azide Free NBP2-24862

Immunogen	Rabbit anti-CXCR4 polyclonal antibody was raised against a peptide corresponding to amino acids 328-338 of human CXCR4.
Isotype	IgG
Clonality	Polyclonal
Host	Rabbit
Gene	CXCR4
Purity	Protein G purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer	PBS
Preservative	0.05% Sodium Azide
Concentration	1.0 mg/ml
Purity	Protein G purified

CXCR4 Antibody

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Publications for CXCR4 Antibody (NB100-56437)(21)

Review for CXCR4 Antibody (NB100-56437) (1) 51

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Publications using NB100-56437	Applications	Species
Hiraide T, Tsuda N, Momoi M et al. CXCL12/CXCR4 pathway as a novel therapeutic target for RNF213 -associated pulmonary arterial hypertension Scientific Reports 2024-11-04 [PMID: 39496725]
Yamamoto Y, Kadoya K, Terkawi MA et al. Neutrophils delay repair process in Wallerian degeneration by releasing NETs outside the parenchyma Life science alliance 2022-10-01 [PMID: 35961782] (IHC-P, Mouse)	IHC-P	Mouse
Zheng M, Oh SH, Choi N et al. CXCL12 inhibits hair growth through CXCR4 Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022-04-21 [PMID: 35462338] (IF/IHC, Mouse)	IF/IHC	Mouse
Queen NJ, Deng H, Huang W et al. Environmental Enrichment Mitigates Age-Related Metabolic Decline and Lewis Lung Carcinoma Growth in Aged Female Mice Cancer Prevention Research 2021-12-01 [PMID: 34535449] (Western Blot)	Western Blot
Lyu C, Ye Y, Lensing MM et al. Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy JCI Insight 2021-09-22 [PMID: 34343132] (Immunohistochemistry)	Immunohistochemistry
Locri F, Dal Monte M, Aronsson M et al. UPARANT is an effective antiangiogenic agent in a mouse model of rubeosis iridis Journal of Molecular Medicine 2019-09-01 [PMID: 31243519] (In vivo assay)	In vivo assay
Pelagalli A, Nardelli A, Lucarelli E et al. Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression J. Cell. Physiol. 2018-01-18 [PMID: 29345324] (WB)	WB
Irie Y, Tsubota M, Ishikura H et al. Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis J Neuroimmune Pharmacol 2017-07-28 [PMID: 28755135] (WB, Mouse)	WB	Mouse
Gagner JP, Sarfraz Y, Ortenzi V et al. Multifaceted C-X-C Chemokine Receptor 4 Inhibition Interferes with Anti-Vascular Endothelial Growth Factor Therapy-Induced Glioma Dissemination. Am. J. Pathol. 2017-07-20 [PMID: 28734730] (WB, Mouse)	WB	Mouse
Dieckow J, Brandt W, Hattermann K et al. CXCR4 and CXCR7 Mediate TFF3-Induced Cell Migration Independently From the ERK1/2 Signaling Pathway. Invest. Ophthalmol. Vis. Sci. 2016-01-01 [PMID: 26780310] (ICC/IF, Human)	ICC/IF	Human
Ghosh MC, Makena PS, Gorantla V et al. CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1 and matrix metalloproteinase-2. Am J Physiol Lung Cell Mol Physiol. 2012-05-01 [PMID: 22345572]
De Silva RA, Peyre K, Pullambhatla M et al. Imaging CXCR4 expression in human cancer xenografts: evaluation of monocyclam 64Cu-AMD3465. J Nucl Med. 2011-06-01 [PMID: 21622896]
Nimmagadda S, Pullambhatla M, Stone K et al. Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography. Cancer Res. 2010-05-15 [PMID: 20460522]
Esencay M, Newcomb EW, Zagzag D. HGF upregulates CXCR4 expression in gliomas via NF-kappaB: implications for glioma cell migration. J Neurooncol. 2010-08-01 [PMID: 20157762]
Hogg K, Etherington SL, Young JM et al. Inhibitor of differentiation (Id) genes are expressed in the steroidogenic cells of the ovine ovary and are differentially regulated by members of the transforming growth factor-beta family. Endocrinology [PMID: 20032053] Details: Used the Azide Free form of this antibody.
Pacheco-Rodriguez G, Kumaki F, Steagall WK et al. Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene. J Immunol. 2009-02-01 [PMID: 19155472] (Human) Details: IHC(paraffin), human lung tissue, Fig. Supp 1: 1. IMG-71201 (CCR1), Fig. 1D.		Human
Zagzag D, Esencay M, Mendez O et al. Hypoxia- and vascular endothelial growth factor-induced stromal cell-derived factor-1alpha/CXCR4 expression in glioblastomas: one plausible explanation of Scherer's structures. Am J Pathol. 2008-08-01 [PMID: 18599607] (ICC/IF, WB, Human) Details: IF (human glioma cell lines LN229, LN308, and U87), Fig. 3B; WB (human glioma cell lines LN229, LN308, and U87), Fig. 3A. Inhibitor of differentiation (Id) genes are expressed in the steriodogenic cells of the ovine ovary and are differentially regulated	ICC/IF, WB	Human
Ma YH, Mentlein R, Knerlich F et al. Expression of stem cell markers in human astrocytomas of different WHO grades. J Neurooncol. 2008-01-01 [PMID: 17611714] (IHC-P, Human) Details: IHC (paraffin), human astrocytoma tissues, Fig. 4.	IHC-P	Human
Zagzag D, Lukyanov Y, Lan L et al. Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion. Lab Invest. 2006-12-01 [PMID: 17075581] Details: WB: Figs 2B, 3A and C, 4B.
Kulbe H, Hagemann T, Szlosarek PW et al. The inflammatory cytokine tumor necrosis factor-alpha regulates chemokine receptor expression on ovarian cancer cells. Cancer Res. 2005-11-15 [PMID: 16288025]
Zagzag D, Krishnamachary B, Yee H et al. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res 2005-07-15 [PMID: 16024619]
Show All 21 Publications. Collapse Publications.

Gene Symbol	CXCR4
Entrez	7852(Human) 12767(Mouse) 60628(Rat)
Uniprot	P61073()

	Verified Customer 03/07/2020
Application:	WB
Species:	Human