CXCL13/BLC/BCA-1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. BCA-1 cDNA encodes a protein of 109 amino acid residues with a leader sequence of 22 residues. Mature human BCA-1 shares 64% amino acid sequence similarity with the mouse protein and 23‑34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA-1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA1. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Primate - Macaca mulatta (Rhesus Macaque), Rabbit, Xenograft.

We have publications tested in 6 applications: Bioassay, ICC, IHC, IHC-Fr, IHC-P, Immunohistochemistry.

Showing Publications 1 - 10 of 39. Show All 39 Publications. Collapse Publications.

Publications using AF801	Applications	Species
Di Modugno, F;Di Carlo, A;Spada, S;Palermo, B;D'Ambrosio, L;D'Andrea, D;Morello, G;Belmonte, B;Sperduti, I;Balzano, V;Gallo, E;Melchionna, R;Panetta, M;Campo, G;De Nicola, F;Goeman, F;Antoniani, B;Carpano, S;Frigè, G;Warren, S;Gallina, F;Lambrechts, D;Xiong, J;Vincent, BG;Wheeler, N;Bortone, DS;Cappuzzo, F;Facciolo, F;Tripodo, C;Visca, P;Nisticò, P; Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancer EBioMedicine 2024-02-09 [PMID: 38340557] (IHC, Human)	IHC	Human
Krenács, L;Krenács, D;Borbényi, Z;Tóth, E;Nagy, A;Piukovics, K;Bagdi, E; Comparison of Follicular Helper T-Cell Markers with the Expression of the Follicular Homing Marker CXCR5 in Peripheral T-Cell Lymphomas-A Reappraisal of Follicular Helper T-Cell Lymphomas International journal of molecular sciences 2023-12-28 [PMID: 38203606] (Immunohistochemistry, Human)	Immunohistochemistry	Human
Mary S. Pampusch, Emily N. Sevcik, Zoe E. Quinn, Brianna C. Davey, James M. Berg, Ian Gorrell-Brown et al. Assessment of anti-CD20 antibody pre-treatment for augmentation of CAR-T cell therapy in SIV-infected rhesus macaques Frontiers in Immunology 2/7/2023 [PMID: 36825014]
Mohey Eldin M. El Shikh, Riham El Sayed, Nesreen Amer Ramadan Aly, Edoardo Prediletto, Rebecca Hands, Liliane Fossati-Jimack et al. Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis Frontiers in Medicine 11/16/2022 [PMID: 36465908]
SK Pierson, L Katz, R Williams, M Mumau, M Gonzalez, S Guzman, A Rubenstein, AB Oromendia, P Beineke, A Fosså, F van Rhee, DC Fajgenbaum CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease Nature Communications, 2022-11-24;13(1):7236. 2022-11-24 [PMID: 36433996] (IHC, Human)	IHC	Human
Qizhi Ma, Yue Chen, Qing Qin, Fuchun Guo, Yong-sheng Wang, Dan Li CXCL13 expression in mouse 4T1 breast cancer microenvironment elicits antitumor immune response by regulating immune cell infiltration Precision Clinical Medicine 9/16/2021 [PMID: 35693216]
M Uzzan, JC Martin, L Mesin, AE Livanos, T Castro-Dop, R Huang, F Petralia, G Magri, S Kumar, Q Zhao, AK Rosenstein, M Tokuyama, K Sharma, R Ungaro, R Kosoy, D Jha, J Fischer, H Singh, ME Keir, N Ramamoorth, WEO Gorman, BL Cohen, A Rahman, F Cossarini, A Seki, L Leyre, ST Vaquero, S Gurunathan, EK Grasset, B Losic, M Dubinsky, AJ Greenstein, Z Gottlieb, P Legnani, J George, H Irizar, A Stojmirovi, C Brodmerkel, A Kasarkis, BE Sands, G Furtado, SA Lira, ZK Tuong, HM Ko, A Cerutti, CO Elson, MR Clatworthy, M Merad, M Suárez-Far, C Argmann, JA Hackney, GD Victora, GJ Randolph, E Kenigsberg, JF Colombel, S Mehandru Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity Nature Medicine, 2022-02-21;0(0):. 2022-02-21 [PMID: 35190725] (IHC, Human)	IHC	Human
J He, X Xiong, H Yang, D Li, X Liu, S Li, S Liao, S Chen, X Wen, K Yu, L Fu, X Dong, K Zhu, X Xia, T Kang, C Bian, X Li, H Liu, P Ding, X Zhang, Z Liu, W Li, Z Zuo, P Zhou Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response Cell Research, 2022-02-14;0(0):. 2022-02-14 [PMID: 35165422] (IHC, Xenograft)	IHC	Xenograft
D Phillips, M Matusiak, BR Gutierrez, SS Bhate, GL Barlow, S Jiang, J Demeter, KS Smythe, RH Pierce, SP Fling, N Ramchurren, MA Cheever, Y Goltsev, RB West, MS Khodadoust, YH Kim, CM Schürch, GP Nolan Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma Nature Communications, 2021-11-18;12(1):6726. 2021-11-18 [PMID: 34795254] (IHC, Human)	IHC	Human
Guangchao Li, Jintao Guo, Yanfang Zheng, Wen Ding, Zheping Han, Lingyu Qin et al. CXCR5 guides migration and tumor eradication of anti-EGFR chimeric antigen receptor T cells Molecular Therapy - Oncolytics 9/24/2021 [PMID: 34553036]
N van Dijk, A Gil-Jimene, K Silina, K Hendrickse, LA Smit, JM de Feijter, ML van Montfo, C van Rooije, D Peters, A Broeks, HG van der Po, A Bruining, Y Lubeck, K Sikorska, TN Boellaard, P Kvistborg, DJ Vis, E Hooijberg, TN Schumacher, M van den Br, LFA Wessels, CU Blank, BW van Rhijn, MS van der He Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial Nat Med, 2020-10-12;0(0):. 2020-10-12 [PMID: 33046870] (IHC, Human)	IHC	Human
N Bellamri, R Viel, C Morzadec, V Lecureur, A Joannes, B de Latour, F Llamas-Gut, L Wollin, S Jouneau, L Vernhet TNF-&alpha and IL-10 Control CXCL13 Expression in Human Macrophages J. Immunol., 2020-03-25;0(0):. 3/25/2020 [PMID: 32213567]
HA Kim, YH Kim, YK Jeon, WI Yang, JE Kwon, JH Han Histopathology and expression of the chemokines CXCL10, CXCL13, and CXCR3 and the endogenous TLR-4 ligand S100A8/A9 in lymph nodes of patients with adult-onset Still's disease Sci Rep, 2019-05-17;9(1):7517. 2019-05-17 [PMID: 31101882] (IHC-P, Human)	IHC-P	Human
C Liu, X Huang, M Werner, R Broering, J Ge, Y Li, B Liao, J Sun, J Peng, M Lu, J Hou, X Zhang Elevated Expression of Chemokine CXCL13 in Chronic Hepatitis B Patients Links to Immune Control during Antiviral Therapy Front Immunol, 2017-03-23;8(0):323. 2017-03-23 [PMID: 28386259] (IHC, Human)	IHC	Human
Yuki Sato, Akiko Mii, Yoko Hamazaki, Harumi Fujita, Hirosuke Nakata, Kyoko Masuda et al. Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney JCI Insight 10/5/2016 [PMID: 27699223]
Agnieszka Pozdzik, Ingrid Beukinga, Chunyan Gu-Trantien, Karen Willard-Gallo, Joëlle Nortier, Olivier Pradier Circulating (CD3(-)CD19(+)CD20(-)IgD(-)CD27(high)CD38(high)) Plasmablasts: A Promising Cellular Biomarker for Immune Activity for Anti-PLA2R1 Related Membranous Nephropathy? Mediators of Inflammation 7/14/2016 [PMID: 27493452]
Jie Guo, Jiang Qian, Rui Zhang The pathological features of ectopic lymphoid neogenesis in idiopathic dacryoadenitis BMC Ophthalmology 12/1/2016 [PMID: 27230507]
Yuliya Pylayeva-Gupta, Shipra Das, Jesse S. Handler, Cristina H. Hajdu, Maryaline Coffre, Sergei B. Koralov et al. IL-35 producing B cells promote the development of pancreatic neoplasia Cancer Discovery 3/1/2016 [PMID: 26715643]
Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia Cancer Discov, 2015-12-29;6(3):256-69. 2015-12-29 [PMID: 26715642] (IHC-P, Human)	IHC-P	Human
Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M CXCL13 antibody for the treatment of autoimmune disorders. BMC Immunol, 2015-02-12;16(0):6. 2015-02-12 [PMID: 25879435] (Bioassay, Human)	Bioassay	Human
Clement M, Guedj K, Andreata F, Morvan M, Bey L, Khallou-Laschet J, Gaston A, Delbosc S, Alsac J, Bruneval P, Deschildre C, Le Borgne M, Castier Y, Kim H, Cantor H, Michel J, Caligiuri G, Nicoletti A Control of the T follicular helper-germinal center B-cell axis by CD8(+) regulatory T cells limits atherosclerosis and tertiary lymphoid organ development. Circulation, 2014-12-31;131(6):560-70. 2014-12-31 [PMID: 25552357] (IHC-P, Human)	IHC-P	Human
Diana Londoño, Diego Cadavid, Elise E. Drouin, Klemen Strle, Gail McHugh, John M. Aversa et al. Antibodies to Endothelial Cell Growth Factor and Obliterative Microvascular Lesions in the Synovium of Patients With Antibiotic-Refractory Lyme Arthritis Arthritis & Rheumatology 10/17/2014 [PMID: 24623727]
Di Caro G, Bergomas F, Grizzi F, Doni A, Bianchi P, Malesci A, Laghi L, Allavena P, Mantovani A, Marchesi F Occurrence of tertiary lymphoid tissue is associated with T-cell infiltration and predicts better prognosis in early-stage colorectal cancers. Clin Cancer Res, 2014-02-12;20(8):2147-58. 2014-02-12 [PMID: 24523438] (IHC-P, Human)	IHC-P	Human
Lucero CM, Fallert Junecko B, Klamar CR et al. Macaque Paneth Cells Express Lymphoid Chemokine CXCL13 and Other Antimicrobial Peptides Not Previously Described as Expressed in Intestinal Crypts. Clin Vaccine Immunol 8/1/2013 [PMID: 23803902]
Chunyan Gu-Trantien, Sherene Loi, Soizic Garaud, Carole Equeter, Myriam Libin, Alexandre de Wind et al. CD4+ follicular helper T cell infiltration predicts breast cancer survival Journal of Clinical Investigation 7/1/2013 [PMID: 23778140]
Saloni Mittal, Matthew Revell, Francesca Barone, Debbie L. Hardie, Gulraj S. Matharu, Alison J. Davenport et al. Lymphoid Aggregates That Resemble Tertiary Lymphoid Organs Define a Specific Pathological Subset in Metal-on-Metal Hip Replacements PLoS ONE 5/28/2013 [PMID: 23723985]
Wanting Liu, Yonghong Peng, Desmond J. Tobin A new 12-gene diagnostic biomarker signature of melanoma revealed by integrated microarray analysis PeerJ 3/5/2013 [PMID: 23638386]
Slight S, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko B, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart T, Randall T, Khader S CXCR5(+) T helper cells mediate protective immunity against tuberculosis. J Clin Invest, 2013-01-02;123(2):712-26. 2013-01-02 [PMID: 23281399] (IHC-P, Human, Primate - Macaca mulatta (Rhesus Macaque))	IHC-P	Human, Primate - Macaca mulatta (Rhesus Macaque)
Fatma Çetinözman, Patty M. Jansen, Maarten H. Vermeer, Rein Willemze Differential Expression of Programmed Death-1 (PD-1) in Sézary Syndrome and Mycosis Fungoides Archives of Dermatology 12/19/2012 [PMID: 23247480]
Rebecca C. Harris, Kimberly A. Chianese-Bullock, Gina R. Petroni, Jochen T. Schaefer, Louis B. Brill, Kerrington R. Molhoek et al. The Vaccine-site Microenvironment Induced by Injection of Incomplete Freund's Adjuvant, With or Without Melanoma Peptides Journal of Immunotherapy 1/1/2012 [PMID: 22130163]
Andrew L. Kirsh, Sharon L. Cushing, Eunice Y. Chen, Stephen M. Schwartz, Jonathan A. Perkins Tertiary Lymphoid Organs in Lymphatic Malformations Lymphatic Research and Biology 6/22/2011 [PMID: 21688977]
Kanzaki S, Yamaguchi A, Yamaguchi K, Kojima Y, Suzuki K, Koumitsu N, Nagashima Y, Nagahama K, Ehara M, Hirayasu Y, Ryo A, Aoki I, Yamanaka S Thymic alterations in GM2 gangliosidoses model mice. PLoS ONE, 2010-08-10;5(8):. 2010-08-10 [PMID: 20856892] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint. Arthritis Rheum., 2008-11-01;58(0):3377-87. 2008-11-01 [PMID: 18975336] (ICC, IHC-P, Human)	ICC, IHC-P	Human
Ramesh G, Borda JT, Dufour J, Kaushal D, Ramamoorthy R, Lackner AA, Philipp MT Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosis. Am. J. Pathol., 2008-10-02;173(5):1415-27. 2008-10-02 [PMID: 18832582] (IHC-Fr, Primate - Macaca mulatta (Rhesus Macaque))	IHC-Fr	Primate - Macaca mulatta (Rhesus Macaque)
Sansonno D, Tucci FA, Troiani L, Lauletta G, Montrone M, Conteduca V, Sansonno L, Dammacco F Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis. Blood, 2008-06-12;112(5):1620-7. 2008-06-12 [PMID: 18550853] (IHC-P, Human)	IHC-P	Human
Vermijlen D, Ellis P, Langford C, Klein A, Engel R, Willimann K, Jomaa H, Hayday AC, Eberl M Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. J. Immunol., 2007-04-01;178(7):4304-14. 2007-04-01 [PMID: 17371987] (IHC-P, Human)	IHC-P	Human
Ohshima K, Karube K, Kawano R, Tsuchiya T, Suefuji H, Yamaguchi T, Suzumiya J, Kikuchii M Classification of distinct subtypes of peripheral T-cell lymphoma unspecified, identified by chemokine and chemokine receptor expression: Analysis of prognosis. Int. J. Oncol., 2004-09-01;25(3):605-13. 2004-09-01 [PMID: 15289861] (IHC-P, Human)	IHC-P	Human
Casazza S, Zappia E, Pistorio A, Gambini C Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. Proc. Natl. Acad. Sci. U.S.A., 2004-07-19;101(30):11064-9. 2004-07-19 [PMID: 15263096] (IHC-P, Human)	IHC-P	Human
Sinha RK, Mage RG Developing neonatal rabbit appendix, a primary lymphoid organ, is seeded by immature blood-borne B cells: evidence for roles for CD62L/PNAd, CCR7/CCL21, alpha4beta1 and LFA-1. Dev. Comp. Immunol., 2004-06-01;28(7):829-41. 2004-06-01 [PMID: 15043950] (IHC, Rabbit)	IHC	Rabbit
Show All 39 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	Immunofluorescence - paraffin	Human	01/16/2020	View Summary Application Other Sample Tested Diffuse large B cell lymphoma Species Human Lot BAS0317102 Comments Comments pH 9 antigen retrieval
	4 reviewed by: Verified Customer	IHC-P	Human	01/09/2015	View Summary Application Immunohistochemistry-Paraffin Sample Tested See PMID 23778140 Species Human

Array AF801

• CXCL13/BLC/BCA-1 Antibodies
• CXCL13/BLC/BCA-1 ELISA Kit
• CXCL13/BLC/BCA-1 Lysate
• CXCL13/BLC/BCA-1 Proteins
• CXCL13/BLC/BCA-1 ELISAs
• CXCL13/BLC/BCA-1 Proteins and Enzymes