CX3CR1 Antibody [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CX3CR1 (CX₃C chemokine receptor 1; also known as fractalkine receptor, GPCR13 and V28) is a 40 kDa member of the δ-group of rhodopsin GPCRs. It is expressed on astrocytes, microglia, macrophages, Th1 and Tc1 T cells, NK cells, mouse Gr1^lo monocytes plus smooth muscle and mast cells. CX3CR1 mediates adhesion to fractalkine, promotes avid binding of integrins to their ligands, and extends the life of monocytes. Mouse CX3CR1 is a 7-transmembrane protein that is 354 amino acids (aa) in length. It contains a 32 aa N-terminal extracellular region that shows no glycosylation, and a 56 aa C-terminal cytoplasmic domain. Over aa 1‑32, 91‑104, 169‑196 and 258‑274 collectively, mouse CX3CR1 shares 96% and 77% aa identity with rat and human CX3CR1, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: Flow Cytometry, ICC, IHC.

Showing Publications 1 - 9 of 9.

Publications using FAB5825P	Applications	Species
V Rai, MB Wood, H Feng, NM Schabla, S Tu, J Zuo The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells Scientific Reports, 2020-09-16;10(1):15167. 2020-09-16 [PMID: 32938973] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
AM Osman, Y Sun, TC Burns, L He, N Kee, N Oliva-Vila, A Alevyzaki, K Zhou, L Louhivuori, P Uhlén, E Hedlund, C Betsholtz, VM Lauschke, J Kele, K Blomgren Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain Cell Rep, 2020-06-02;31(9):107699. 2020-06-02 [PMID: 32492415] (IHC, Mouse)	IHC	Mouse
A Cougnoux, RA Drummond, M Fellmeth, F Navid, AL Collar, J Iben, AB Kulkarni, J Pickel, R Schiffmann, CA Wassif, NX Cawley, MS Lionakis, FD Porter Unique molecular signature in mucolipidosis type IV microglia J Neuroinflammation, 2019-12-28;16(1):276. 2019-12-28 [PMID: 31883529] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Natascha Köstlin-Gille, Stefanie Dietz, Julian Schwarz, Bärbel Spring, Jan Pauluschke-Fröhlich, Christian F. Poets et al. HIF-1 alpha -Deficiency in Myeloid Cells Leads to a Disturbed Accumulation of Myeloid Derived Suppressor Cells (MDSC) During Pregnancy and to an Increased Abortion Rate in Mice Frontiers in Immunology 2019-02-05 [PMID: 30804946]
A Cougnoux, RA Drummond, AL Collar, JR Iben, A Salman, H Westgarth, CA Wassif, NX Cawley, NY Farhat, K Ozato, MS Lionakis, FD Porter Microglia Activation in Niemann-Pick Disease, type C1 is Amendableto Therapeutic Intervention Hum. Mol. Genet., 2018-06-15;0(0):. 2018-06-15 [PMID: 29617956] (ICC, Mouse)	ICC	Mouse
Bryan Simons PGI2 Controls Pulmonary NK Cells That Prevent Airway Sensitization to House Dust Mite Allergen J. Immunol, 2016-11-28;0(0):. 2016-11-28 [PMID: 27895167] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization EMBO Mol Med, 2016-12-01;0(0):. 2016-12-01 [PMID: 27861126] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
S Wattananit, D Tornero, N Graubardt, T Memanishvi, E Monni, J Tatarishvi, G Miskinyte, R Ge, H Ahlenius, O Lindvall, M Schwartz, Z Kokaia Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice J Neurosci, 2016-04-13;36(15):4182-95. 2016-04-13 [PMID: 27076418] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
van Nieuwenhuijze A, Coghill E, Gray D, Prato S, Metcalf D, Alexander W, Wicks I Transgenic expression of GM-CSF in T cells causes disseminated histiocytosis. Am J Pathol, 2013-10-30;184(1):184-99. 2013-10-30 [PMID: 24183847] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	Flow	Mouse	04/04/2019	View Summary Application Flow Cytometry Sample Tested brain and spinal cord Species Mouse Lot ACN50414101 Comments Comments Experimental autoimmune encephalomyelitis was induced in C57BL6/J mice, and mononuclear cells were isolated from the CNS when the animals were at the onset of symptoms (day 10). Cells were stained for CX3CR1, CCR2, CD45, CD11b, CD11c, CD4, CD8, CCR2, CCR5, CCR7, and CXCR4, plus for viability to exclude dead cells. Viable cells stained for CX3CR1 (blue) and FMO sample for CX3CR1 (stained for all the markers except for CX3CR1; red).

Array FAB5825P

• CX3CR1 Antibodies
• CX3CR1 ELISA Kits
• CX3CR1 Proteins