cIAP (pan) Antibody (315301) - Pan Specific

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cellular inhibitor of apoptosis protein1 (cIAP-1, also known as BIRC2, MIHB, and HIAP2) and 2 (cIAP-2, also known as BIRC3, MIHC, and HIAP1), are members of the inhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. Structurally, cIAP-1 and cIAP-2 are each comprised of 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). Human cIAP-1 and cIAP-2 share 70% sequence identity. Functionally, cIAPs inhibits caspases through the direct interaction of its BIR domain with the active caspase. The ring finger domain of cIAP-1 and -2 also functions as an E3 ubiquitin ligase to ubiqutinylate specific target proteins. Caspase activity may be restored by mitochondrial proteins, such as SMAC/Diablo or HtrA2/Omi, through interactions with the Reaper-like motif and the BIR domain. cIAPs are reported to be cleaved by HtrA2/Omi.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Chicken.

We have publications tested in 5 applications: Flow Cytometry, IHC, IHC-P, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 26. Show All 26 Publications. Collapse Publications.

Publications using MAB3400	Applications	Species
B Dumétier, A Zadoroznyj, J Berthelet, S Causse, J Allègre, P Bourgeois, F Cattin, C Racoeur, C Paul, C Garrido, L Dubrez cIAP1/TRAF2 interplay promotes tumor growth through the activation of STAT3 Oncogene, 2022-11-18;0(0):. 2022-11-18 [PMID: 36400972] (Western Blot, Human)	Western Blot	Human
Xin Liu, Jimmy J. Yao, Zhongxuan Chen, Wei Lei, Rong Duan, Zhenqiang Yao Lipopolysaccharide sensitizes the therapeutic response of breast cancer to IAP antagonist Frontiers in Immunology 2022-08-31 [PMID: 36119107]
G Wu, D Li, W Liang, W Sun, X Xie, Y Tong, B Shan, M Zhang, X Lu, J Yuan, Y Li PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFalpha-mediated cell death Cell Death & Disease, 2022-09-07;13(9):773. 2022-09-07 [PMID: 36071040] (Immunoprecipitation, Western Blot, Mouse)	Immunoprecipitation, Western Blot	Mouse
L García-Gut, E Fallahi, N Aboud, N Quinn, D Matallanas Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner Cell Death & Disease, 2022-08-08;13(8):692. 2022-08-08 [PMID: 35941108] (Immunoprecipitation, Western Blot, Human)	Immunoprecipitation, Western Blot	Human
Y Hu, H Zhang, N Xie, D Liu, Y Jiang, Z Liu, D Ye, S Liu, X Chen, C Li, Q Wang, X Huang, Y Liu, Y Shi, X Zhang Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1 Cell Death and Differentiation, 2021-12-01;0(0):. 2021-12-01 [PMID: 34853447] (Flow Cytometry, IHC, Mouse)	Flow Cytometry, IHC	Mouse
Antonella Montinaro, Itziar Areso Zubiaur, Julia Saggau, Anna-Laura Kretz, Rute M. M. Ferreira, Omar Hassan et al. Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers Cell Death & Differentiation 2022-03-01 [PMID: 34535764]
Emmanuelle Supper, Saskia Rudat, Vivek Iyer, Alastair Droop, Kim Wong, Jean-François Spinella et al. Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia Nature Communications 2021-04-30 [PMID: 33931647]
Lars Pache, Matthew D. Marsden, Peter Teriete, Alex J. Portillo, Dominik Heimann, Jocelyn T. Kim et al. Pharmacological Activation of Non-canonical NF-kappa B Signaling Activates Latent HIV-1 Reservoirs In Vivo Cell Reports Medicine 2020-06-23 [PMID: 33205060]
IS Kang, JS Jang, C Kim Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation Sci Rep, 2020-04-27;10(1):7024. 2020-04-27 [PMID: 32341385] (Western Blot, Mouse)	Western Blot	Mouse
W Lei, R Duan, J Li, X Liu, A Huston, BF Boyce, Z Yao The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice Sci Rep, 2020-04-24;10(1):7004. 2020-04-24 [PMID: 32332865] (Western Blot, Mouse)	Western Blot	Mouse
VR Barnhouse, JL Weist, VC Shukla, SN Ghadiali, DA Kniss, JL Leight Myoferlin regulates epithelial cancer cell plasticity and migration through autocrine TGF-?1 signaling Oncotarget, 2018-04-10;9(27):19209-19222. 4/10/2018 [PMID: 29721195]
T Goncharov, S Hedayati, MM Mulvihill, A Izrael-Tom, K Zobel, S Jeet, AV Fedorova, C Eidenschen, J deVoss, K Yu, AS Shaw, DS Kirkpatric, WJ Fairbrothe, K Deshayes, D Vucic Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling Mol. Cell, 2018-02-15;69(4):551-565.e7. 2018-02-15 [PMID: 29452636] (Western Blot, Mouse)	Western Blot	Mouse
Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis PLoS ONE, 2016-09-12;11(9):e0161952. 2016-09-12 [PMID: 27617834] (Western Blot, Human)	Western Blot	Human
Christina Helmke, Monika Raab, Franz Rödel, Yves Matthess, Thomas Oellerich, Ranadip Mandal et al. Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8 Cell Research 2016-08-01 [PMID: 27325299]
N Rebolleda, I Losada-Fer, G Perez-Chac, R Castejon, S Rosado, M Morado, MT Vallejo-Cr, A Martinez, JA Vargas-Nuñ, P Perez-Acie Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model PLoS ONE, 2016-04-21;11(4):e0154159. 2016-04-21 [PMID: 27101369] (Western Blot, Human, Mouse)	Western Blot	Human, Mouse
Laiqun Zhang, Ken Blackwell, Lauren M. Workman, Songhai Chen, Marshall R. Pope, Siegfried Janz et al. RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-kappa B Activation and Lymphoma Survival Molecular and Cellular Biology 2015-10-01 [PMID: 26195820]
Moriwaki K, Bertin J, Gough P, Chan F A RIPK3-caspase 8 complex mediates atypical pro-IL-1beta processing. J Immunol, 2015-01-07;194(4):1938-44. 2015-01-07 [PMID: 25567679] (Western Blot, Mouse)	Western Blot	Mouse
Zhang L, Dittmer M, Blackwell K, Workman L, Hostager B, Habelhah H TRAIL activates JNK and NF-kappaB through RIP1-dependent and -independent pathways. Cell Signal, 2014-11-18;27(2):306-14. 2014-11-18 [PMID: 25446254] (Western Blot, Human)	Western Blot	Human
Faye M, Beug S, Graber T, Earl N, Xiang X, Wild B, Langlois S, Michaud J, Cowan K, Korneluk R, Holcik M IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1. Oncogene, 2014-04-07;34(12):1532-41. 2014-04-07 [PMID: 24704827] (IHC-P, Human)	IHC-P	Human
Shuo Yang, Bingwei Wang, Lisa S. Tang, Jakub Siednienko, John J. Callanan, Paul N. Moynagh Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-alpha Nature Communications 2013-10-11 [PMID: 24113711]
Yang S, Wang B, Humphries F et al. Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis. Nat Immunol 7/28/2013 [PMID: 23892723]
Moreno-Garcia M, Sommer K, Rincon-Arano H, Brault M, Ninomiya-Tsuji J, Matesic L, Rawlings D Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-kappaB activation. Mol Cell Biol, 2013-01-07;33(6):1149-63. 2013-01-07 [PMID: 23297344] (Western Blot, Chicken, Human)	Western Blot	Chicken, Human
Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, Abhyankar A, Israel L, Trevejo-Nunez G, Bogunovic D, Cepika A, MacDuff D, Chrabieh M, Hubeau M, Bajolle F, Debre M, Mazzolari E, Vairo D, Agou F, Virgin H, Bossuyt X, Rambaud C, Facchetti F, Bonnet D, Quartier P, Fournet J, Pascual V, Chaussabel D, Notarangelo L, Puel A, Israel A, Casanova J, Picard C Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat Immunol, 2012-10-28;13(12):1178-86. 10/28/2012 [PMID: 23104095]
Perez-Chacon G, Llobet D, Pardo C, Pindado J, Choi Y, Reed JC, Zapata JM TNFR-Associated Factor 2 Deficiency in B Lymphocytes Predisposes to Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in Mice. J. Immunol., 2012-06-18;189(2):1053-61. 2012-06-18 [PMID: 22711886] (Western Blot, Mouse)	Western Blot	Mouse
Gerlach B, Cordier SM, Schmukle AC, Emmerich CH, Rieser E, Haas TL, Webb AI, Rickard JA, Anderton H, Wong WW, Nachbur U, Gangoda L, Warnken U, Purcell AW, Silke J, Walczak H Linear ubiquitination prevents inflammation and regulates immune signalling. Nature, 2011-03-31;471(7340):591-6. 2011-03-31 [PMID: 21455173] (Western Blot, Human)	Western Blot	Human
Jin HR, Jin X, Lee JJ Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-kappaB pathway. Biochem. Biophys. Res. Commun., 2010-09-06;400(4):581-6. 2010-09-06 [PMID: 20804734] (Western Blot, Human)	Western Blot	Human
Show All 26 Publications. Collapse Publications.

Array MAB3400

• cIAP (pan) Antibody