CD300a/LMIR1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD300a, also known as LMIR1 (in rodents), CMRF-35H, IRp60, CLM-8, and MAIR-I, is a 60 kDa glycoprotein member of the immunoglobulin superfamily (1). Human LMIR1 consists of a 163 amino acid (aa) extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane segment, and a 98 aa cytoplasmic domain that contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and a non-canonical ITIM (2). Alternate splicing may generate additional isoforms that either lack the Ig-like domain or contain only the cytoplasmic domain. Within the ECD, human LMIR1 shares 40% and 43% aa sequence identity with mouse and rat LMIR1, respectively. In human, LMIR1 is expressed on peripheral blood eosinophils, mast cells, neutrophils, plasmacytoid dendritic cells, and various T cell subsets (3‑7). Antibody crosslinking of LMIR1 induces phosphorylation of tyrosine residues in the cytoplasmic domain. This leads to the recruitment of phosphatases SHIP, SHP-1, and SHP-2 and inhibition of NK cell, eosinophil, and mast cell activation (2, 3, 5‑7). Crosslinking of LMIR1 to other surface proteins such as SCF R or Fc epsilon RI on mast cells, Fc gamma RIIA on neutrophils, or CCR3 on mast cells and eosinophils inhibits downstream signaling from those receptors (5, 10‑12). LMIR1 crosslinking also limits the in vivo activities of these cells with a subsequent reduction of allergic inflammation symptoms (4, 11, 12).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 2 of 2.

Publications using AF2640	Applications	Species
Oeyen, M;Heymann, CJF;Jacquemyn, M;Daelemans, D;Schols, D; The Role of TIM-1 and CD300a in Zika Virus Infection Investigated with Cell-Based Electrical Impedance Biosensors 2024-07-25 [PMID: 39194591] (Bioassay, Human)	Bioassay	Human
Carnec X, Meertens L, Dejarnac O, Perera-Lecoin M, Hafirassou M, Kitaura J, Ramdasi R, Schwartz O, Amara A The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances Infection. J Virol, 2015-10-14;90(1):92-102. 10/14/2015 [PMID: 26468529]

Array AF2640

• CD300a/LMIR1 Antibodies
• CD300a/LMIR1 Lysate
• CD300a/LMIR1 Protein
• CD300a/LMIR1 ELISA
• CD300a/LMIR1 Proteins and Enzymes