Home » NKG2A/CD159a/KLRC1 » NKG2A/CD159a/KLRC1 Antibodies » NKG2A/CD159a/KLRC1 Antibody (131411) [Unconjugated]
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NKG2A/CD159a/KLRC1 Antibody (131411) [Unconjugated]

 (17 Publications)
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Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM‑1/CD56 APC‑conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2A/CD159a Monoclonal Antibody (Catalog # MAB1059) or (B) Mouse IgG2A Isotype Control (Catalog # MAB003) followed by Anti-Mouse IgG PE-conjugated secondary antibody (Catalog # F0101B). View our protocol for Staining Membrane-associated Proteins.
Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM‑1/CD56 APC‑conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2A/CD159a Monoclonal ...read more
HEK293 Human embryonic kidney cell line transfected with either (A) Human NKG2A/CD159a, or (B) Human NKG2B/CD159b and eGFP was stained with Mouse Anti-Human NKG2A/CD159a Monoclonal Antibody (Catalog # MAB1059) followed ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
131411
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB1059U-100UG
Alexa Fluor 405
FAB1059V-100UG
Alexa Fluor 488
FAB1059G-100UG
Alexa Fluor 532
FAB1059X
Alexa Fluor 594
FAB1059T-100UG
Alexa Fluor 647
FAB1059R-100UG
Alexa Fluor 700
FAB1059N-100
Alexa Fluor 700
FAB1059N-025
Alexa Fluor 750
FAB1059S-100UG
Allophycocyanin
FAB1059A-025
Allophycocyanin
FAB1059A-100
Allophycocyanin/Cy7
FAB1059APCCY7
Biotin
FAB1059B-025
CoraFluor 1
FAB1059CL1
DyLight 350
FAB1059D
DyLight 405
FAB1059E
DyLight 488
FAB1059K
DyLight 550
FAB1059L
DyLight 594
FAB1059M
DyLight 650
FAB1059W
DyLight 680
FAB1059Y
DyLight 755
FAB1059Z
FITC
FAB1059F
HRP
FAB1059H
Janelia Fluor 525
FAB1059JF525
Janelia Fluor 549
FAB1059I
Janelia Fluor 585
FAB1059JF585
Janelia Fluor 635
FAB1059JF635
Janelia Fluor 646
FAB1059J
Janelia Fluor 669
FAB1059JF669
PE/Atto594
FAB1059PEATT594
PE/Cy5.5
FAB1059PECY55
PE/Cy7
FAB1059PECY7
PerCP (Peridinin-chlorophyll Protein Complex)
FAB1059C-025
PerCP (Peridinin-chlorophyll Protein Complex)
FAB1059C-100
Phycoerythrin
FAB1059P-100
Phycoerythrin
FAB1059P-025
mFluor Violet 450 SE
FAB1059MFV450
mFluor Violet 500 SE
FAB1059MFV500
mFluor Violet 610 SE
FAB1059MFV610
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
FAB1059B-025
Carrier Free
FAB1059R-100UG
Carrier Free
FAB1059S-100UG
Carrier Free
FAB1059T-100UG
Carrier Free
FAB1059U-100UG
Carrier Free
FAB1059V-100UG
Carrier Free
MAB1059-500
Carrier Free
MAB1059-SP
Carrier Free
FAB1059C-025
Carrier Free
FAB1059N-100
Carrier Free
FAB1059N-025
Carrier Free
FAB1059A-100
Carrier Free
FAB1059A-025
Carrier Free
FAB1059P-100
Carrier Free
FAB1059P-025
Carrier Free
FAB1059C-100
Carrier Free
FAB1059G-100UG
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NKG2A/CD159a/KLRC1 Antibody (131411) [Unconjugated] Summary

Immunogen
BaF3 mouse pro-B cell line transfected with human NKG2A and CD94
Specificity
Recognizes the human NKG2A/CD94 heterodimer. It does not recognize the NKG2C/CD94 heterodimer or the CD94 homodimer.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
KLRC1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
Publications
Read Publications using
MAB1059 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NKG2A/CD159a/KLRC1 Antibody (131411) [Unconjugated]

  • CD159 antigen-like family member A
  • CD159a antigen
  • CD159a
  • C-lectin type II protein
  • killer cell lectin-like receptor subfamily C, member 1
  • Klrc1
  • MGC13374
  • natural killer cell lectin
  • natural killer group protein 2
  • NK cell receptor A
  • NKG2
  • NKG2-1/B activating NK receptor
  • NKG2A
  • NKG2-A
  • NKG2-A/B type II integral membrane protein
  • NKG2-A/B-activating NK receptor
  • NKG2-A/NKG2-B type II integral membrane protein
  • NKG2AMGC59791
  • NKG2-B

Background

NKG2A, also known as CD159a, is a type II transmembrane receptor having a single extracellular lectin-like domain and a cytoplasmic ITIM motif. It associates with CD94 and is expressed on NK cells and some activated T cell populations. The NKG2A/CD94 complex delivers an inhibitory signal upon recognition of its ligand, HLA-E.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for NKG2A/CD159a/KLRC1 Antibody (MAB1059)(17)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 7 applications: Affinity Chromatography, CyTOF-reported, ELISA Capture, Flow Cytometry, Functional Assay, Immunoprecipitation, Neutralization.


Filter By Application
Affinity Chromatography
(1)
CyTOF-reported
(1)
ELISA Capture
(1)
Flow Cytometry
(10)
Functional Assay
(1)
Immunoprecipitation
(1)
Neutralization
(2)
All Applications
Filter By Species
Human
(15)
Mouse
(1)
All Species
Showing Publications 1 - 10 of 17. Show All 17 Publications.
Publications using MAB1059 Applications Species
Wang, J;Chai, Q;Lei, Z;Wang, Y;He, J;Ge, P;Lu, Z;Qiang, L;Zhao, D;Yu, S;Qiu, C;Zhong, Y;Li, BX;Zhang, L;Pang, Y;Gao, GF;Liu, CH; LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis EMBO molecular medicine 2024-07-19 [PMID: 39030302] (CyTOF-reported, Human) CyTOF-reported Human
Scopelliti, F;Dimartino, V;Cattani, C;Cavani, A; Functional TRPA1 Channels Regulate CD56dimCD16+ NK Cell Cytotoxicity against Tumor Cells International journal of molecular sciences 2023-09-29 [PMID: 37834182] (Flow Cytometry, Human) Flow Cytometry Human
L Jiang, H Fei, X Jin, X Liu, C Yang, C Li, J Chen, A Yang, J Zhu, H Wang, X Fei, S Zhang Extracellular Vesicle-Mediated Secretion of HLA-E by Trophoblasts Maintains Pregnancy by Regulating the Metabolism of Decidual NK Cells International journal of biological sciences, 2021-10-22;17(15):4377-4395. 2021-10-22 [PMID: 34803505] (Flow Cytometry, Human) Flow Cytometry Human
GT Hò, AA Celik, T Huyton, W Hiemisch, R Blasczyk, GS Simper, C Bade-Doedi NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain Int J Mol Sci, 2020-06-19;21(12):. 2020-06-19 [PMID: 32575403] (Affinity Chromatography, ELISA Capture, Human) Affinity Chromatography, ELISA Capture Human
WC Pump, T Kraemer, T Huyton, GT Hò, R Blasczyk, C Bade-Doedi Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8? T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia Int J Mol Sci, 2019-03-22;20(6):. 2019-03-22 [PMID: 30909402] (Immunoprecipitation, Human) Immunoprecipitation Human
B Müller-Dur, J Grählert, OP Devine, AN Akbar, C Hess CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age Aging (Albany NY), 2019-01-27;11(2):724-740. 2019-01-27 [PMID: 30686790] (Flow Cytometry, Human) Flow Cytometry Human
H Sun, J Xu, Q Huang, M Huang, K Li, K Qu, H Wen, R Lin, M Zheng, H Wei, W Xiao, R Sun, Z Tian, C Sun Reduced CD160 expression contributes to impaired NK cell function and poor clinical outcomes in patients with HCC Cancer Res., 2018-09-19;0(0):. 2018-09-19 [PMID: 30232222] (Flow Cytometry, Human) Flow Cytometry Human
Y Xia, Q Zhang, Q Zhen, Y Zhao, N Liu, T Li, Y Hao, Y Zhang, C Luo, X Wu Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway Oncotarget, 2017-06-06;8(23):37783-37795. 2017-06-06 [PMID: 28384121] (Flow Cytometry, Human) Flow Cytometry Human
Zhao D, Xu A, Dai Z, Peng J, Zhu M, Shen J, Zheng Q, Ran Z WNT5A transforms intestinal CD8alphaalpha(+) IELs into an unconventional phenotype with pro-inflammatory features. BMC Gastroenterol, 2015-12-10;15(0):173. 2015-12-10 [PMID: 26652024] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Wang F, Zhou Y, Fu B, Wu Y, Zhang R, Sun R, Tian Z, Wei H Molecular signatures and transcriptional regulatory networks of human immature decidual NK and mature peripheral NK cells. Eur J Immunol, 2014-06-11;44(9):2771-84. 2014-06-11 [PMID: 24838931] (Flow Cytometry, Human) Flow Cytometry Human
Show All 17 Publications.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol KLRC1