CD25/IL-2R alpha Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human CD25, also known as IL-2 receptor alpha (IL-2 R alpha ) and asTac antigen, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2. The IL-2 R alpha cDNA encodes a 272 amino acid residue precursor Type I membrane protein with a 21 residue signal peptide, a 219 residue extracellular region, a 19 residue transmembrane region and a 13 residue cytoplasmic domain. IL-2 R alpha lacks structural features characteristic of members of the cytokine receptor superfamily. By itself, IL-2 R alpha binds IL-2 with low affinity. However, when IL-2 R alpha is associated with the IL-2 receptor beta and gamma chains, a high affinity heterotrimeric receptor complex that transduces IL-2 signals is formed. Soluble forms of many cytokine receptors have been reported, and a soluble form of IL-2 R alpha (IL-2 sR alpha ) appears in serum, concomitant with its increased expression on cells. The function of the soluble IL-2 R alpha is unclear. Increased levels of IL-2 sR alpha in biological fluids reportedly correlate with increased T and B cell activation and immune system activation. Increased serum concentration of IL-2 sR alpha has been observed in patients with a variety of inflammatory conditions and in the course of some leukemias and lymphomas.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using AF-223-NA	Applications	Species
Laurel K. Saldinger, Seldy G. Nelson, Rebecca R. Bellone, Mary Lassaline, Maura Mack, Naomi J. Walker et al. Horses with equine recurrent uveitis have an activated CD4+ T‐cell phenotype that can be modulated by mesenchymal stem cells in vitro Veterinary Ophthalmology 1/1/2020 [PMID: 31441218]
Zheng CF, Jones GJ, Shi M, Wiseman JC, Marr KJ, Berenger BM, Huston SM, Gill MJ, Krensky AM, Kubes P, Mody CH Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients. J. Immunol., 2008-06-01;180(11):7221-9. 2008-06-01 [PMID: 18490721] (Flow Cytometry, Western Blot, Human)	Flow Cytometry, Western Blot	Human
Binder M, Vogtle FN, Michelfelder S, Muller F, Illerhaus G, Sundararajan S, Mertelsmann R, Trepel M Identification of their epitope reveals the structural basis for the mechanism of action of the immunosuppressive antibodies basiliximab and daclizumab. Cancer Res., 2007-04-15;67(8):3518-23. 2007-04-15 [PMID: 17440057] (Flow Cytometry, Human)	Flow Cytometry	Human
Jason F. Kreisberg, Wes Yonemoto, Warner C. Greene Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high molecular mass APOBEC3G complex formation The Journal of Experimental Medicine 4/17/2006 [PMID: 16606671]
Li QR, Ma J, Wang H, Li JS Interleukin-2alpha receptor in membrane lipid rafts. Transplant. Proc., 2005-06-01;37(5):2395-7. 2005-06-01 [PMID: 15964425] (Western Blot, Human)	Western Blot	Human
Sandrin V, Muriaux D, Darlix JL, Cosset FL Intracellular trafficking of Gag and Env proteins and their interactions modulate pseudotyping of retroviruses. J. Virol., 2004-07-01;78(13):7153-64. 2004-07-01 [PMID: 15194792] (Western Blot, Human)	Western Blot	Human

Array AF-223-NA

• CD25/IL-2R alpha Antibodies
• CD25/IL-2R alpha ELISA Kits
• CD25/IL-2R alpha Protein
• CD25/IL-2R alpha Proteins and Enzymes
• CD25/IL-2R alpha ELISAs