CCL5/RANTES Antibody (53405) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL5, also known as RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted), is an 8 kDa beta -chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes (1-3). Human and mouse RANTES exhibit cross-species activity on human and mouse cells (4). Mature mouse CCL5 shares 100% amino acid (aa) sequence identity with rat CCL5 and 75-88% with canine, cotton rat, feline, and human CCL5 (5). CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5 (6, 7). Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28 (8). In humans, CCR5 binding to CCL5 inhibits the infectivity of R5 (M-tropic) but not X4 (T-tropic) strains of HIV-1 (9). The two N-terminal residues of CCL5 can be removed by CD26/DPPIV, generating a protein that functions as a chemotaxis inhibitor and more effectively blocks M-tropic HIV-1 infection of monocytes (10). Oligomerization of CCL5 on glycosaminoglycans is required for CCR1-mediated leukocyte adhesion and activation as well as CCL5’s interaction with the chemokine CXCL4/PF4 (11-13). The deposition of CCL5 on activated vascular endothelial cells is crucial for monocyte adhesion to damaged vasculature, but CCL5 oligomerization is not required for the extravasation of adherent leukocytes (14-16). CCL5 is upregulated in breast cancer and promotes tumor progression through the attraction of pro-inflammatory macrophages in addition to its actions on tumor cells, stromal cells, and the vasculature (17).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 8 applications: Bioassay, ELISA Development, ELISA Development (Capture), ICC, IHC-Fr, In Vivo, In vivo assay, Neutralization.

Showing Publications 1 - 10 of 29. Show All 29 Publications. Collapse Publications.

Publications using MAB478	Applications	Species
Chi, G;Lu, J;He, T;Wang, Y;Zhou, X;Zhang, Y;Qiu, L; High mobility group box-1 protein promotes astrocytic CCL5 production through the MAPK/NF-?B pathway following spinal cord injury Scientific reports 2024-09-27 [PMID: 39333662] (In vivo assay, Rat)	In vivo assay	Rat
Bénard, A;Mittelstädt, A;Klösch, B;Glanz, K;Müller, J;Schoen, J;Nüse, B;Brunner, M;Naschberger, E;Stürzl, M;Mattner, J;Muñoz, LE;Sohn, K;Grützmann, R;Weber, GF; IL-3 orchestrates ulcerative colitis pathogenesis by controlling the development and the recruitment of splenic reservoir neutrophils Cell reports 2023-06-08 [PMID: 37300834] (In Vivo, Mouse)	In Vivo	Mouse
Tang, T;Huang, X;Lu, M;Zhang, G;Han, X;Liang, T; Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner Nature communications 2023-06-08 [PMID: 37291128] (In Vivo, Rat)	In Vivo	Rat
Zhichong Wu, Kevin Thierry, Sophie Bachy, Xinyi Zhang, Pia Gamradt, Hector Hernandez‐Vargas et al. Pericyte stem cells induce Ly6G + cell accumulation and immunotherapy resistance in pancreatic cancer EMBO reports 2023-04-05 [PMID: 36802267]
Jing Liu, Xiaoting Liang, Mimi Li, Fang Lin, Xiaoxue Ma, Yuanfeng Xin et al. Intramyocardial injected human umbilical cord-derived mesenchymal stem cells (HucMSCs) contribute to the recovery of cardiac function and the migration of CD4+ T cells into the infarcted heart via CCL5/CCR5 signaling Stem Cell Research & Therapy 2022-12-01 [PMID: 35690805]
Kuo Jiang, Qianfeng Zhang, Yong Fan, Jia Li, Jitao Zhang, Wentao Wang et al. MYC inhibition reprograms tumor immune microenvironment by recruiting T lymphocytes and activating the CD40/CD40L system in osteosarcoma Cell Death Discovery 2022-03-15 [PMID: 35292660]
Amanda de Andrade Costa, Jit Chatterjee, Olivia Cobb, Elizabeth Cordell, Astoria Chao, Suzanne Schaeffer et al. Immune deconvolution and temporal mapping identifies stromal targets and developmental intervals for abrogating murine low-grade optic glioma formation Neuro-Oncology Advances 2022-02-21 [PMID: 35187488]
Na Zhao, Hien Dang, Lichun Ma, Sean P. Martin, Marshonna Forgues, Kris Ylaya et al. Intratumoral gamma δ T‐Cell Infiltrates, Chemokine (C‐C Motif) Ligand 4/Chemokine (C‐C Motif) Ligand 5 Protein Expression and Survival in Patients With Hepatocellular Carcinoma Hepatology 2022-05-28 [PMID: 32502310]
W Seo, K Shimizu, S Kojo, A Okeke, T Kohwi-Shig, SI Fujii, I Taniuchi Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity Nat Commun, 2020-03-26;11(1):1562. 2020-03-26 [PMID: 32218434] (Neutralization, Mouse)	Neutralization	Mouse
M Fortier, M Cadoux, N Boussetta, S Pham, R Donné, JP Couty, C Desdouets, S Celton-Mor Hepatospecific ablation of p38alpha MAPK governs liver regeneration through modulation of inflammatory response to CCl4-induced acute injury Sci Rep, 2019-10-10;9(1):14614. 2019-10-10 [PMID: 31601995] (In Vivo, Mouse)	In Vivo	Mouse
AK Verma, TS Waghmare, GR Jachak, SC Philkhana, DS Reddy, A Basu Nitrosporeusine analogue ameliorates Chandipura virus induced inflammatory response in CNS via NF?b inactivation in microglia PLoS Negl Trop Dis, 2018-07-12;12(7):e0006648. 2018-07-12 [PMID: 30001342] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
JP Böttcher, E Bonavita, P Chakravart, H Blees, M Cabeza-Cab, S Sammicheli, NC Rogers, E Sahai, S Zelenay, C Reis E Sou NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control Cell, 2018-02-08;172(5):1022-1037.e14. 2018-02-08 [PMID: 29429633] (Neutralization, Mouse)	Neutralization	Mouse
JW Lee, A Hoshino, K Inoue, T Saitou, S Uehara, Y Kobayashi, S Ueha, K Matsushima, A Yamaguchi, Y Imai, T Iimura The HIV co-receptor CCR5 regulates osteoclast function Nat Commun, 2017-12-20;8(1):2226. 2017-12-20 [PMID: 29263385] (Neutralization, Mouse)	Neutralization	Mouse
M Aswad, S Assi, S Schif-Zuck, A Ariel CCL5 Promotes Resolution-Phase Macrophage Reprogramming in Concert with the Atypical Chemokine Receptor D6 and Apoptotic Polymorphonuclear Cells J. Immunol., 2017-07-03;0(0):. 2017-07-03 [PMID: 28674178] (Neutralization, Mouse)	Neutralization	Mouse
Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway J Neuroinflammation, 2016-08-30;13(1):209. 2016-08-30 [PMID: 27576490] (Bioassay, Neutralization, Mouse)	Bioassay, Neutralization	Mouse
Koh MY, Gagea M, Sargis T et al. A new HIF-1alpha/RANTES driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF. Hepatology. 1/22/2016 [PMID: 26799785]
M. E. Mikucki, D. T. Fisher, J. Matsuzaki, J. J. Skitzki, N. B. Gaulin, J. B. Muhitch et al. Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints Nature Communications 2015-06-25 [PMID: 26109379]
Sottnik J, Dai J, Zhang H, Campbell B, Keller E Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases. Cancer Res, 2015-04-08;75(11):2151-8. 2015-04-08 [PMID: 25855383] (Neutralization, Human)	Neutralization	Human
Claire Arnaud, Pauline C. Beguin, Sylvie Lantuejoul, Jean-Louis Pepin, Christiane Guillermet, Graziano Pelli et al. The Inflammatory Preatherosclerotic Remodeling Induced by Intermittent Hypoxia Is Attenuated by RANTES/CCL5 Inhibition American Journal of Respiratory and Critical Care Medicine 2011-09-15 [PMID: 21680945]
Samantha R. Stubblefield Park, Mi Widness, Alan D. Levine, Catherine E. Patterson T Cell-, Interleukin-12-, and Gamma Interferon-Driven Viral Clearance in Measles Virus-Infected Brain Tissue Journal of Virology 2011-04-01 [PMID: 21270150]
Kovacic JC, Gupta R, Lee AC, Ma M, Fang F, Tolbert CN, Walts AD, Beltran LE, San H, Chen G, St Hilaire C, Boehm M Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. J. Clin. Invest., 2009-12-28;120(1):303-14. 12/28/2009 [PMID: 20038813]
Herz J, Pardo J, Kashkar H, Schramm M, Kuzmenkina E, Bos E, Wiegmann K, Wallich R, Peters PJ, Herzig S, Schmelzer E, Kronke M, Simon MM, Utermohlen O Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes. Nat. Immunol., 2009-06-14;10(7):761-8. 2009-06-14 [PMID: 19525969] (ICC, Mouse)	ICC	Mouse
Cruickshank SM, Deschoolmeester ML, Svensson M, Howell G, Bazakou A, Logunova L, Little MC, English N, Mack M, Grencis RK, Else KJ, Carding SR Rapid dendritic cell mobilization to the large intestinal epithelium is associated with resistance to Trichuris muris infection. J. Immunol., 2009-03-01;182(5):3055-62. 2009-03-01 [PMID: 19234202] (Neutralization, Mouse)	Neutralization	Mouse
Di Liberto D, Locati M, Caccamo N, Vecchi A, Meraviglia S, Salerno A, Sireci G, Nebuloni M, Caceres N, Cardona PJ, Dieli F, Mantovani A Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection. J. Exp. Med., 2008-08-11;205(9):2075-84. 2008-08-11 [PMID: 18695004] (Neutralization, Mouse)	Neutralization	Mouse
Lu Y, McNearney TA, Wilson SP, Yeomans DC, Westlund KN Joint capsule treatment with enkephalin-encoding HSV-1 recombinant vector reduces inflammatory damage and behavioural sequelae in rat CFA monoarthritis. Eur. J. Neurosci., 2008-03-01;27(5):1153-65. 2008-03-01 [PMID: 18364035] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Fujita H, Asahina A, Komine M, Tamaki K The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells. Cell. Immunol., 2007-05-15;245(2):70-9. 2007-05-15 [PMID: 17507001] (Neutralization, Mouse)	Neutralization	Mouse
Martinez de la Torre Y, Buracchi C, Borroni EM, Dupor J, Bonecchi R, Nebuloni M, Pasqualini F, Doni A, Lauri E, Agostinis C, Bulla R, Cook DN, Haribabu B, Meroni P, Rukavina D, Vago L, Tedesco F, Vecchi A, Lira SA, Locati M, Mantovani A Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6. Proc. Natl. Acad. Sci. U.S.A., 2007-02-05;104(7):2319-24. 2007-02-05 [PMID: 17283337] (Neutralization, Mouse)	Neutralization	Mouse
Mosmann T Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions. Eur. J. Immunol., 2004-06-01;34(6):1617-26. 2004-06-01 [PMID: 15162431] (ELISA Development, Mouse)	ELISA Development	Mouse
Faunce DE, Stein-Streilein J NKT cell-derived RANTES recruits APCs and CD8+ T cells to the spleen during the generation of regulatory T cells in tolerance. J. Immunol., 2002-07-01;169(1):31-8. 2002-07-01 [PMID: 12077225] (Neutralization, Mouse)	Neutralization	Mouse
Show All 29 Publications. Collapse Publications.

Array MAB478

• CCL5/RANTES Antibodies
• CCL5/RANTES Antibody Pair
• CCL5/RANTES ELISA Kit
• CCL5/RANTES Lysate
• CCL5/RANTES Proteins
• CCL5/RANTES ELISAs
• CCL5/RANTES Proteins and Enzymes