Name: CCL5/RANTES Antibody (21418) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB678
Price: 479 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, PmSpecies Glossary
Applications	WB, B/N, ELISA(Cap)
Clone	21418
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Catalog# & Formulation	Size	Price
Carrier Free MAB678-SP

Carrier Free MAB678-500

Immunogen	E. coli-derived recombinant human CCL5/RANTES
Specificity	Detects human and primate CCL5/RANTES in direct ELISAs and Western blots. When used in combination with the biotinylated anti-human/primate CCL5/RANTES detection antibody (Catalog # BAF278) in sandwich ELISAs, no significant cross-reactivity or interference is observed with recombinant human (rh) ANG, rhCNTF, rh beta -ECGF, rhEGF, mouse (m) EGF, rhEpo, bovine (b) FGF acidic, rhFGF acidic, bFGF basic, rhFGF basic, rhFGF-4, rhG-CSF, rhGM-CSF, recombinant mouse (rm) GM-CSF, rhGRO alpha , rhIFN-gamma , rhIGF-I, rhIGF-II, rhIL-1 alpha , rmIL-1 alpha , rhIL-1 beta , rmIL‑1 beta , rhIL-1ra, recombinant rat (rr) IL-1ra, rhIL-2, rhIL-3, rmIL-3, rmIL-4, rhIL-5, rmIL-5, rhIL-6, rmIL-6, rhIL-7, rmIL-7, rhIL-8, rhIL-9, rmIL-9, rhIL‑10, rhIL-11, rhLIF, rhMCP‑1, rhM-CSF, rhMIP-1 alpha , rmMIP-1 alpha , rhMIP-1 beta , rmMIP-1 beta , rhOSM, human (h) PDGF, pPDGF, rhPDGF-AA, rhPDGF‑AB, rhPDGF-BB, rhSCF, rmSCF, rhSLPI, rhTGF-alpha , pTGF-beta 1, hTGF-beta 1, rhTGF-beta 1, pTGF-beta 2, rhTGF-beta 2, recombinant canine TGF-beta 3, rhTGF-beta 3, recombinant amphibian TGF-beta 5, rhTNF-alpha , rmTNF-alpha , or rmTNF-beta .
Source	N/A
Isotype	IgG1
Clonality	Monoclonal
Host	Mouse
Gene	CCL5
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

CCL5/RANTES Antibody (21418) [Unconjugated]

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Publications for CCL5/RANTES Antibody (MAB678)(38)

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Publications using MAB678	Applications	Species
S Lee, YJ Seo, JY Choi, X Che, HJ Kim, SY Eum, MS Hong, SK Lee, DC Cho Effect of teriparatide on drug treatment of tuberculous spondylitis: an experimental study Scientific Reports, 2022-12-15;12(1):21667. 2022-12-15 [PMID: 36522387] (ELISA Capture, Human)	ELISA Capture	Human
Kyung-min Lee, Chang-Ching Lin, Alberto Servetto, Joonbeom Bae, Vishal Kandagatla, Dan Ye et al. Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer Cancer Immunology Research 7/1/2022 [PMID: 35561311]
Peijian Zhang, Erlinda The, Zichao Luo, Yufeng Zhai, Qingzhou Yao, Lihua Ao et al. Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity Molecular Medicine 12/1/2022 [PMID: 35062861]
X Sun, Z Chen Cancer-associated fibroblast-derived CCL5 contributes to cisplatin resistance in A549 NSCLC cells partially through upregulation of lncRNA HOTAIR expression Oncology Letters, 2021-08-02;22(4):696. 2021-08-02 [PMID: 34457051] (Neutralization, Human)	Neutralization	Human
YF Sun, L Wu, SP Liu, MM Jiang, B Hu, KQ Zhou, W Guo, Y Xu, Y Zhong, XR Zhou, ZF Zhang, G Liu, S Liu, YH Shi, Y Ji, M Du, NN Li, GB Li, ZK Zhao, XY Huang, LQ Xu, QC Yu, DH Peng, SJ Qiu, HC Sun, M Dean, XD Wang, WY Chung, AR Dennison, J Zhou, Y Hou, J Fan, XR Yang Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma Nature Communications, 2021-07-02;12(1):4091. 2021-07-02 [PMID: 34215748] (Neutralization, Human)	Neutralization	Human
C Kötting, L Hofmann, R Lotfi, D Engelhardt, S Laban, PJ Schuler, TK Hoffmann, C Brunner, MN Theodoraki Immune-Stimulatory Effects of Curcumin on the Tumor Microenvironment in Head and Neck Squamous Cell Carcinoma Cancers, 2021-03-16;13(6):. 2021-03-16 [PMID: 33809574] (ELISA Capture, Human)	ELISA Capture	Human
PS Arunachala, TP Charles, V Joag, VS Bollimpell, MKD Scott, F Wimmers, SL Burton, CC Labranche, C Petitdeman, S Gangadhara, TM Styles, CF Quarnstrom, KA Walter, TJ Ketas, T Legere, PB Jagadeesh, SP Kasturi, A Tsai, BZ Yeung, S Gupta, M Tomai, J Vasilakos, GM Shaw, CY Kang, JP Moore, S Subramania, P Khatri, D Montefiori, PA Kozlowski, CA Derdeyn, E Hunter, D Masopust, RR Amara, B Pulendran T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers Nat. Med., 2020-05-11;0(0):. 2020-05-11 [PMID: 32393800] (ELISA Capture, Human)	ELISA Capture	Human
Song Jin, Peng Xiang, Jie Liu, Yang Yang, Shuai Hu, Jindong Sheng et al. Activation of cGMP/PKG/p65 signaling associated with PDE5‐Is downregulates CCL5 secretion by CD8 + T cells in benign prostatic hyperplasia The Prostate 6/1/2019 [PMID: 30958912]
WC Liao, HR Yen, CK Liao, TJ Tseng, CT Lan, CH Liu DSE regulates the malignant characters of hepatocellular carcinoma cells by modulating CCL5/CCR1 axis Am J Cancer Res, 2019-02-01;9(2):347-362. 2019-02-01 [PMID: 30906633] (Neutralization, Human)	Neutralization	Human
Jennifer A. Juno, Kathleen M. Wragg, Anne B. Kristensen, Wen Shi Lee, Kevin J. Selva, Renee M. van der Sluis et al. Modulation of the CCR5 Receptor/Ligand Axis by Seminal Plasma and the Utility of In Vitro versus In Vivo Models Journal of Virology 6/1/2019 [PMID: 30867307]
S Auclair, F Liu, Q Niu, W Hou, G Churchyard, C Morgan, N Frahm, S Nitayaphan, P Pitisuthit, S Rerks-Ngar, JT Kimata, L Soong, G Franchini, M Robb, J Kim, N Michael, H Hu Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection PLoS Pathog., 2018-02-23;14(2):e1006888. 2018-02-23 [PMID: 29474461] (Neutralization, Human)	Neutralization	Human
YL Zhang, Q Li, XM Yang, F Fang, J Li, YH Wang, Q Yang, L Zhu, HZ Nie, XL Zhang, MX Feng, SH Jiang, GA Tian, LP Hu, HY Lee, SJ Lee, Q Xia, ZG Zhang SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin-Rho GTPase-Hippo Pathways Cancer Res., 2018-02-13;0(0):. 2018-02-13 [PMID: 29440144] (Neutralization, Human)	Neutralization	Human
S Urata, K Izumi, K Hiratsuka, A Maolake, A Natsagdorj, K Shigehara, H Iwamoto, S Kadomoto, T Makino, R Naito, Y Kadono, WJ Lin, G Wufuer, K Narimoto, A Mizokami C-C motif ligand 5 promotes migration of prostate cancer cells in the prostate cancer bone metastasis microenvironment Cancer Sci., 2018-02-14;109(3):724-731. 2018-02-14 [PMID: 29288523] (Functional Assay, Human)	Functional Assay	Human
SJ Zhao, YQ Jiang, NW Xu, Q Li, Q Zhang, SY Wang, J Li, YH Wang, YL Zhang, SH Jiang, YJ Wang, YJ Huang, XX Zhang, GA Tian, CC Zhang, YY Lv, M Dai, F Liu, R Zhang, D Zhou, ZG Zhang SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/?-catenin signaling through stabilization of the WNT-receptor complex Oncogene, 2017-10-30;0(0):. 2017-10-30 [PMID: 29084211] (Bioassay, Human)	Bioassay	Human
Y Yang, S Hu, J Liu, Y Cui, Y Fan, T Lv, L Liu, J Li, Q He, W Han, W Yu, Y Sun, J Jin CD8+ T cells promote proliferation of benign prostatic hyperplasia epithelial cells under low androgen level via modulation of CCL5/STAT5/CCND1 signaling pathway Sci Rep, 2017-02-20;7(0):42893. 2017-02-20 [PMID: 28216616] (Neutralization, Human)	Neutralization	Human
CM Henry, SJ Martin Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory FADDosome Complex upon TRAIL Stimulation Mol. Cell, 2017-02-16;65(4):715-729.e5. 2017-02-16 [PMID: 28212752] (ICC, Human)	ICC	Human
Fabrice Cerini, Hubert Gaertner, Knut Madden, Ilya Tolstorukov, Scott Brown, Bram Laukens et al. A scalable low-cost cGMP process for clinical grade production of the HIV inhibitor 5P12-RANTES in Pichia pastoris Protein Expression and Purification 3/1/2016 [PMID: 26506568]
Oynebraten I, Barois N, Bergeland T, Kuchler A, Bakke O, Haraldsen G Oligomerized, filamentous surface presentation of RANTES/CCL5 on vascular endothelial cells. Sci Rep, 2015-03-20;5(0):9261. 3/20/2015 [PMID: 25791723]
Yu Fan, Shuai Hu, Jie Liu, Fei Xiao, Xin Li, Wei Yu et al. Low intraprostatic DHT promotes the infiltration of CD8+ T cells in BPH tissues via modulation of CCL5 secretion Mediators of Inflammation 4/6/2014 [PMID: 24808637]
Sirpa Salo, Carolina Bitu, Kalle Merkku, Pia Nyberg, Ibrahim O Bello, Jussi Vuoristo et al. Human Bone Marrow Mesenchymal Stem Cells Induce Collagen Production and Tongue Cancer Invasion PLoS ONE 10/21/2013 [PMID: 24204919]
Osei-Kumah A, Smith R, Clifton VL Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma. Cytokine, 2008-07-17;43(2):187-93. 2008-07-17 [PMID: 18639465] (ELISA Development, Human)	ELISA Development	Human
Pfleger C, Kaas A, Hansen L, Alizadeh B, Hougaard P, Holl R, Kolb H, Roep BO, Mortensen HB, Schloot NC Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes. Clin. Immunol., 2008-04-22;128(1):57-65. 2008-04-22 [PMID: 18434252] (ELISA Development, Human)	ELISA Development	Human
Gonzalez RM, Seurynck-Servoss SL, Crowley SA Development and validation of sandwich ELISA microarrays with minimal assay interference. J. Proteome Res., 2008-04-19;7(6):2406-14. 2008-04-19 [PMID: 18422355] (ELISA Microarray Development, Human)	ELISA Microarray Development	Human
Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62. 2008-03-01 [PMID: 18327985] (Luminex Development, Human)	Luminex Development	Human
Qui H, Ferrell EP, Nolan N, Phelps BH, Tabibiazar R, Whitney DH, Naelfski EA Fluorescence single-molecule counting assays for high-sensitivity detection of cytokines and chemokines. Clin. Chem., 2007-11-01;53(11):2010-2. 2007-11-01 [PMID: 18030696] (ELISA Development, Human)	ELISA Development	Human
Aldinucci D, Lorenzon D, Cattaruzza L, Pinto A, Gloghini A, Carbone A, Colombatti A Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions. Int. J. Cancer, 2008-02-15;122(4):769-76. 2008-02-15 [PMID: 17935139] (Neutralization, Human)	Neutralization	Human
Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P Ultrasensitive flow-based immunoassays using single-molecule counting. Clin. Chem., 2007-09-21;53(11):1990-5. 2007-09-21 [PMID: 17890441] (ELISA Development, Human)	ELISA Development	Human
Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS, 2007;21(10):1263-72. 2007 [PMID: 17545702] (Luminex Development, Human)	Luminex Development	Human
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (Luminex Development, Human)	Luminex Development	Human
Tikhonov I, Deetz CO, Paca R, Berg S, Lukyanenko V, Lim JK, Pauza CD Human Vgamma2Vdelta2 T cells contain cytoplasmic RANTES. Int. Immunol., 2006-06-01;18(8):1243-51. 2006-06-01 [PMID: 16740603] (Mass Spectometry, Human)	Mass Spectometry	Human
Cho ML, Min SY, Chang SH, Kim KW, Heo SB, Lee SH, Park SH, Cho CS, Kim HY Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression. Immunol. Lett., 2006-03-03;105(2):159-66. 2006-03-03 [PMID: 16564576] (ELISA Development, Human)	ELISA Development	Human
Edwards MR, Johnson MW, Johnston SL Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells. Am. J. Respir. Cell Mol. Biol., 2006-01-19;34(5):616-24. 2006-01-19 [PMID: 16424382] (ELISA Development, Human)	ELISA Development	Human
Dioszeghy V, Benlhassan-Chahour K, Delache B, Dereuddre-Bosquet N, Aubenque C, Gras G, Le Grand R, Vaslin B Changes in soluble factor-mediated CD8+ cell-derived antiviral activity in cynomolgus macaques infected with simian immunodeficiency virus SIVmac251: relationship to biological markers of progression. J. Virol., 2006-01-01;80(1):236-45. 2006-01-01 [PMID: 16352548] (ELISA Development, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	ELISA Development	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Rubina W. Saeed, Santosh Varma, Tina Peng-Nemeroff, Barbara Sherry, David Balakhaneh, Jared Huston et al. Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation The Journal of Experimental Medicine 4/4/2005 [PMID: 15809354]
Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J. Immunol., 2002-11-01;169(9):5244-51. 2002-11-01 [PMID: 12391243] (ELISA Development, Human)	ELISA Development	Human
Hirst SJ, Hallsworth MP, Peng Q Selective induction of eotaxin release by interleukin-13 or interleukin-4 in human airway smooth muscle cells is synergistic with interleukin-1beta and is mediated by the interleukin-4 receptor alpha-chain. Am. J. Respir. Crit. Care Med., 2002-04-15;165(8):1161-71. 2002-04-15 [PMID: 11956062] (ELISA Development, Human)	ELISA Development	Human
Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity, 2001-06-01;14(6):705-14. 2001-06-01 [PMID: 11420041] (ELISA Development, Human)	ELISA Development	Human
Bottcher MF, Jenmalm MC, Bjorksten B, Garofalo RP Chemoattractant factors in breast milk from allergic and nonallergic mothers. Pediatr. Res., 2000-05-01;47(5):592-7. 2000-05-01 [PMID: 10813582] (ELISA Development, Human)	ELISA Development	Human
Show All 38 Publications. Collapse Publications.