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CCL17/TARC Antibody (110904)

 (18 Publications)
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Recombinant Mouse CCL17/TARC (Catalog # 529-TR) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CCR4 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Mouse CCL17/TARC (20 ng/mL) is neutralized (green line) by increasing concentrations of Mouse CCL17/TARC Monoclonal Antibody (Catalog # MAB529). The ND50 is typically 0.75-3.0 µg/mL.
Recombinant Mouse CCL17/TARC (Catalog # 529-TR) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CCR4 in a dose-dependent manner (orange line). The amount of cells that migrated through to ...read more
CCL17-mediated chemotaxis is inhibited in a dose-dependent manner by B202 and B225.EL4 cells were incubated with mouse CCL17 at 2/mL in the presence and absence of (A) B202, (B) B225 (C) CNTO 5516 which is an irrelevant ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications B/N, ELISA(Cap)
Clone
110904
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB529-SP
Carrier Free
MAB529-500
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CCL17/TARC Antibody (110904) Summary

Immunogen
E. coli-derived Recombinant Mouse CCL17/TARC
Ala24-Pro93
Accession # Q9WUZ6
Specificity
Detects mouse CCL17/TARC in ELISAs.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
CCL17
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • Neutralization 0.75-3.0 ug/mL
Application Notes
ELISA Detection: Mouse CCL17/TARC Biotinylated Antibody (Catalog number BAF529)
Standard: Recombinant Mouse CCL17/TARC (Catalog number 529-TR)
Publications
Read Publications using
MAB529 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CCL17/TARC Antibody (110904)

  • ABCD-2
  • CC chemokine TARC
  • C-C motif chemokine 17
  • CCL17
  • chemokine (C-C motif) ligand 17
  • MGC138273
  • SCYA17
  • SCYA17MGC138271
  • small inducible cytokine subfamily A (Cys-Cys), member 17
  • Small-inducible cytokine A17
  • T cell-directed CC chemokine
  • TARC
  • TARCA-152E5.3
  • Thymus and activation-regulated chemokine

Background

Human thymus and activation-regulated chemokine (TARC) also known as CCL17, is a novel CC chemokine identified using a signal sequence trap method. Mouse CCL17 was discovered as a dendritic cell (DC) specific gene by differentiation RNA display. Mouse CCL17 cDNA encodes a highly basic 93 amino acid (aa) residue precursor protein with a 23 aa residue putative signal peptide that is cleaved to generate the 70 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24-29% amino acid sequence identity with RANTES, MIP-1 alpha , MIP-1 beta , MCP-1, MCP-2, MCP-3, and I-309. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. Mouse CCL17 is constitutively expressed in thymic DC, and at a lower level in lymph node DC in the lung. Recombinant CCL17 has been shown to be chemotactic for T cell lines and antigen-primed T helper cells. In humans, CCL17 was identified to be a specific functional ligand for CCR4 and CCR8, receptors that are selectively expressed on T cells.

  1. Imai, T. et al. (1997) J. Biol. Chem. 272:15036.
  2. Imai, T. et al. (1996) J. Biol. Chem. 271:21514.
  3. Nomiyama, H. et al. (1997) Genomics 40:211.
  4. Lieberam, I. et al. (1999) Eur. J. Immunol. 29:2684.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CCL17/TARC Antibody (MAB529)(18)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: Cell Selection, Direct ELISA, ELISA Development, Luminex Development, Neutralization.


Filter By Application
Cell Selection
(1)
Direct ELISA
(1)
ELISA Development
(3)
Luminex Development
(1)
Neutralization
(11)
All Applications
Filter By Species
Human
(1)
Mouse
(15)
All Species
Showing Publications 1 - 10 of 18. Show All 18 Publications.
Publications using MAB529 Applications Species
Yang Zhang, Yicong Ye, Xiaoqiang Tang, Hui Wang, Toshiko Tanaka, Ran Tian et al. CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure Journal of Experimental Medicine 8/1/2022 [PMID: 35687056]
S Deng, P Jin, P Sherchan, S Liu, Y Cui, L Huang, JH Zhang, Y Gong, J Tang Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice Journal of Neuroinflammation, 2021-03-01;18(1):62. 2021-03-01 [PMID: 33648537] (Neutralization, Mouse) Neutralization Mouse
MC Lee, R Saleh, A Achuthan, AJ Fleetwood, I Förster, JA Hamilton, AD Cook CCL17 blockade as a therapy for osteoarthritis pain and disease Arthritis Res. Ther., 2018-04-05;20(1):62. 2018-04-05 [PMID: 29622035] (Neutralization, Mouse) Neutralization Mouse
AD Cook, MC Lee, R Saleh, HW Khiew, AD Christense, A Achuthan, AJ Fleetwood, DC Lacey, JE Smith, I Förster, JA Hamilton TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17 JCI Insight, 2018-03-22;3(6):. 2018-03-22 [PMID: 29563337] (Neutralization, Mouse) Neutralization Mouse
L Fülle, N Steiner, M Funke, F Gondorf, F Pfeiffer, J Siegl, FV Opitz, SK Ha beta el, AB Erazo, O Schanz, HJ Stunden, M Blank, C Gröber, K Händler, M Beyer, H Weighardt, E Latz, JL Schultze, G Mayer, I Förster RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In�Vivo Mol. Ther., 2017-10-13;0(0):. 2017-10-13 [PMID: 29103909] (Neutralization, Mouse) Neutralization Mouse
iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation Cell Rep, 2016-09-20;16(12):3260-72. 2016-09-20 [PMID: 27653688] (Neutralization, Mouse) Neutralization Mouse
Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation J Clin Invest, 2016-08-15;0(0):. 2016-08-15 [PMID: 27525438] (Neutralization, Mouse) Neutralization Mouse
Ohama H, Asai A, Ito I, Suzuki S, Kobayashi M, Higuchi K, Suzuki F M2b macrophage elimination and improved resistance of mice with chronic alcohol consumption to opportunistic infections. Am J Pathol, 2014-12-06;185(2):420-31. 2014-12-06 [PMID: 25485859] (Cell Selection, Mouse) Cell Selection Mouse
Santulli-Marotto S, Boakye K, Lacy E, Wu S, Luongo J, Kavalkovich K, Coelho A, Hogaboam C, Ryan M Engagement of two distinct binding domains on CCL17 is required for signaling through CCR4 and establishment of localized inflammatory conditions in the lung. PLoS ONE, 2013-12-05;8(12):e81465. 2013-12-05 [PMID: 24339934] (Direct ELISA, Neutralization, Mouse) Direct ELISA, Neutralization Mouse
Sandra Santulli-Marotto, Jamie Fisher, Theodore Petley, Ken Boakye, Tadas Panavas, Jennifer Luongo et al. Surrogate Antibodies That Specifically Bind and Neutralize CCL17 But Not CCL22 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 6/12/2013 [PMID: 23750473]
Show All 18 Publications.

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Bioinformatics

Gene Symbol CCL17
Uniprot