Alpha Actinin 4 Antibody (4D10)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 4 of 4.

Publications using H00000081-M01	Applications	Species
Xu X, Honda K, Miura N et al. Actinin-4 splice variant - a complementary diagnostic and prognostic marker of pancreatic neuroendocrine neoplasms. J Cancer. 2020-02-10 [PMID: 32127958]
Aguilar-Hernandez N, Silva-Ayala D, Lopez S, and Arias CF The actin cytoskeleton is important for rotavirus internalization and RNA genome replication. Virus Res. 2019-04-09 [PMID: 30639190]
Shiraishi H, Fujiwara Y, Kakuya T et al. Actinin-4 protein overexpression as a predictive biomarker in adjuvant chemotherapy for resected lung adenocarcinoma. Biomark Med 2017-06-29 [PMID: 28658966]
Yamada S, Yanamoto S, Yoshida H et al. RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 2009-11-11 [PMID: 19913389]

Array H00000081-M01

• Alpha Actinin 4 Antibodies
• Alpha Actinin 4 ELISA Kit
• Alpha Actinin 4 Lysate
• Alpha Actinin 4 Proteins