KRAS Antibody (3B10-2F2)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ICC/IF, IP, WB.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using H00003845-M01	Applications	Species
Alexandra A, Ryan L, Chun-Hao H et al. Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi. Cell Rep Methods. 2022-06-21 [PMID: 35880017]
Anke B, Sheryll E, Daniel G et al. EndoBind detects endogenous protein-protein interactions in real time. Commun Biol. 2021-09-15 [PMID: 34526658]
Seon-Hyeong L, Yoon J, Joon K et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer. Cancers (Basel). 2020-05-28 [PMID: 32481524]
Almas Y, Wai L, Victor L et al. Grifolin, neogrifolin and confluentin from the terricolous polypore Albatrellus flettii suppress KRAS expression in human colon cancer cells. PLoS One. 2020-05-05 [PMID: 32369483]
Sherekar M, Han SW, Ghirlando R et al. Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer J. Biol. Chem. 2020-01-24 [PMID: 31836666] (WB, Human)	WB	Human
Cao S, Chung S, Kim S et al. K-Ras G-domain binding with signaling lipid phosphatidylinositol (4,5)-phosphate (PIP2): membrane association, protein orientation, and function. J Biol Chem. 2019-02-21 [PMID: 30792310]
Ahmed TA, Adamopoulos C, Karoulia Z et al. SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors. Cell Rep 2019-01-02 [PMID: 30605687] (WB, Human)	WB	Human
Garcia-Berrocoso T, Llombart V, Colas-Campas L et al. Single Cell Immuno-laser Microdissection Coupled to Label-free Proteomics to Reveal the Proteotypes of Human Brain Cells After Ischemia Mol. Cell Proteomics. 2017-11-13 [PMID: 29133510] (ICC/IF, Human)	ICC/IF	Human
Kuracha MR, Thomas P, Loggie BW, Govindarajan V et al. Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies. PLoS One 2017-06-22 [PMID: 28640835]
Forzati F, De Martino M, Esposito F et al. miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene. BMC Cancer 2017-03-04 [PMID: 28259135]
Madureira PA, Bharadwaj AG, Bydoun M et al. Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10. Oncotarget 2016-06-24 [PMID: 27351226]
Ambrosini G, Khanin R, Carvajal RD et al. Overexpression of DDX43 mediates MEK-Inhibitor Resistance through RAS up-regulation in Uveal Melanoma Cells. Mol Cancer Ther 2014-06-04 [PMID: 24899684]
King S, Bray S, Galbraith S et al. Evidence for aldosterone-dependent growth of renal cell carcinoma. Int J Exp Pathol. 2014-05-07 [PMID: 24802662]
Subramani A, Alsidawi S, Jagannathan S et al. The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis. Sci Rep. 2013-08-09 [PMID: 23928793] (WB, Human)	WB	Human
Valtorta E, Misale S, Sartore-Bianchi A et al. KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy. Int J Cancer. 2013-01-21 [PMID: 23404247]
Hsu SP, Lee WS et al. Progesterone receptor activation of extranuclear signaling pathways in regulating p53 expression in vascular endothelial cells. Mol Endocrinol 2011-03-01 [PMID: 21239614] (WB, IP, Human)	WB, IP	Human
Fuentes-Calvo I, Blazquez-Medela AM, Santos E et al. Analysis of k-ras nuclear expression in fibroblasts and mesangial cells. PLoS One 5(1):e8703. 2010-01-14 [PMID: 20090846]
Show All 17 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Anon ymous	WB	Human	03/14/2014	View Summary Application Western Blot Sample Tested Whole cell lysate from the following human lung cancer lines: H23, H358, A549, H441. Species Human

Array H00003845-M01

• KRAS Antibodies
• KRAS Lysate
• KRAS Proteins