Name: VCAM-1/CD106 Antibody (BBIG-V1) [Unconjugated]
Brand: Novus Biologicals
SKU: BBA5
Rating: 4 (1 reviews)

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, IP, B/N, ICC/IF
Clone	BBIG-V1
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated
Concentration	LYOPH

Immunogen	Activated HUVEC human umbilical vein endothelial cells
Specificity	The antibody was screened using COS cells transfected with cDNAs for E-Selectin, VCAM-1, ICAM-1 and PECAM-1 and was shown to be specific for human VCAM-1/CD106.
Source	N/A
Isotype	IgG1
Clonality	Monoclonal
Host	Mouse
Gene	VCAM1
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Sterile PBS to a final concentration of 0.5 mg/mL.

Publications using BBA5	Applications	Species
Suehiro, JI;Kimura, T;Fukutomi, T;Naito, H;Kanki, Y;Wada, Y;Kubota, Y;Takakura, N;Sakurai, H; Endothelial specific LAT1 ablation normalizes tumor vasculature JCI insight 2024-08-20 [PMID: 39163136] (Western Blot, Human)	Western Blot	Human
Park, CS;Yoshihara, H;Gao, Q;Qu, C;Iacobucci, I;Ghate, PS;Connelly, JP;Pruett-Miller, SM;Wagner, B;Robinson, CG;Mishra, A;Peng, J;Yang, L;Rankovic, Z;Finkelstein, D;Luger, S;Litzow, M;Paietta, EM;Hebbar, N;Velasquez, MP;Mullighan, CG; Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia Cell reports 7/14/2023 [PMID: 37453060]
Orianne Constant, Ghizlane Maarifi, Jonathan Barthelemy, Marie-France Martin, Bachirou Tinto, Giovanni Savini et al. Differential effects of Usutu and West Nile viruses on neuroinflammation, immune cell recruitment and blood–brain barrier integrity Emerging Microbes & Infections 12/31/2023 [PMID: 36495563]
Michael R. Blatchley, Franklyn Hall, Dimitris Ntekoumes, Hyunwoo Cho, Vidur Kailash, Rafael Vazquez‐Duhalt et al. Discretizing Three‐Dimensional Oxygen Gradients to Modulate and Investigate Cellular Processes Advanced Science 7/1/2021 [PMID: 34151527]
Masahiro Takeuchi, Paula T Vidigal, Mateus T Guerra, Melanie A Hundt, Marie E Robert, Maria Olave-Martinez et al. Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis Gut 11/19/2020 [PMID: 33214166]
M Clé, C Desmetz, J Barthelemy, MF Martin, O Constant, G Maarifi, V Foulongne, K Bolloré, Y Glasson, F De Bock, M Blaquiere, L Dehouck, N Pirot, E Tuaillon, S Nisole, F Najioullah, P Van de Per, A Cabié, N Marchi, F Gosselet, Y Simonin, S Salinas Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier MBio, 2020-08-04;11(4):. 2020-08-04 [PMID: 32753493] (Neutralization, Human)	Neutralization	Human
Nora M. Schacher, Dorette Raaz‑Schrauder, Francesca Pasutto, Florian M. Stumpfe, Miyuki Tauchi, Barbara Dietel et al. Impact of single nucleotide polymorphisms in the VEGFR2 gene on endothelial cell activation under non‑uniform shear stress International Journal of Molecular Medicine 8/5/2019 [PMID: 31432097]
Yousef H, Czupalla CJ, Lee D et al. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nat Med. 2019 May 13 [PMID: 31086348] (ICC/IF, IP, Mouse)	ICC/IF, IP	Mouse
Yousef H, Czupalla CJ, Lee D et al. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nat Med 2019 May 13 [PMID: 31086348] (ICC/IF, IP, Mouse)	ICC/IF, IP	Mouse
Gareth W. Fearnley, Izma Abdul-Zani, Antony M. Latham, Monica C. Hollstein, John E. Ladbury, Stephen B. Wheatcroft et al. Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function Biology Open 5/17/2019 [PMID: 31072823]
SM Koura, M Salama, M El-Hussiny, MEA Khalil, A Lotfy, SA Hassan, SA Gad Elhak, MA Sobh Fluoxetine induces direct inhibitory effects on mesenchymal stem cell?derived osteoprogenitor cells independent of serotonin concentration Mol Med Rep, 2019-02-01;0(0):. 2019-02-01 [PMID: 30720108] (Flow Cytometry, Rat)	Flow Cytometry	Rat
A Li, JH Cho, B Reid, CC Tseng, L He, P Tan, CY Yeh, P Wu, Y Li, RB Widelitz, Y Zhou, M Zhao, RH Chow, CM Chuong Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks Nat Commun, 2018-12-18;9(1):5377. 2018-12-18 [PMID: 30560870]
NF Luz, R Khouri, J Van Weyenb, DL Zanette, PP Fiuza, A Noronha, A Barral, VS Boaventura, DB Prates, FK Chan, BB Andrade, VM Borges Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression Front Microbiol, 2018-09-28;9(0):2283. 2018-09-28 [PMID: 30323793]
J Meng, C Zhou, B Hu, M Luo, Y Yang, Y Wang, W Wang, G Jiang, J Hong, S Li, H Wu, S Yan, W Yan Stevioside Prevents Wear Particle-Induced Osteolysis by Inhibiting Osteoclastogenesis and Inflammatory Response via the Suppression of TAK1 Activation Front Pharmacol, 2018-09-26;9(0):1053. 2018-09-26 [PMID: 30319406]
LE Byrnes, DM Wong, M Subramania, NP Meyer, CL Gilchrist, SM Knox, AD Tward, CJ Ye, JB Sneddon Lineage dynamics of murine pancreatic development at single-cell resolution Nat Commun, 2018-09-25;9(1):3922. 2018-09-25 [PMID: 30254276]
AM Lager, OG Corradin, JM Cregg, MS Elitt, HE Shick, BLL Clayton, KC Allan, HE Olsen, M Madhavan, PJ Tesar Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells Nat Commun, 2018-09-13;9(1):3708. 2018-09-13 [PMID: 30213958]
Patrick Hofmann, Janina Sommer, Kosta Theodorou, Luisa Kirchhof, Ariane Fischer, Yuhuang Li et al. Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling Cardiovascular Research 1/1/2019 [PMID: 30107531]
SS Kotha, BJ Hayes, KT Phong, MA Redd, K Bomsztyk, A Ramakrishn, B Torok-Stor, Y Zheng Engineering a multicellular vascular niche to model hematopoietic cell trafficking Stem Cell Res Ther, 2018-03-23;9(1):77. 2018-03-23 [PMID: 29566751] (Neutralization)	Neutralization
FW Lam, Q Da, B Guillory, MA Cruz Recombinant Human Vimentin Binds to P-Selectin and Blocks Neutrophil Capture and Rolling on Platelets and Endothelium J. Immunol., 2018-01-15;0(0):. 2018-01-15 [PMID: 29335256] (Blocking, Human)	Blocking	Human
PJ Stewart-Hu, TP Szasz, ER Jaeger, MD Onken, JA Cooper, SC Morley Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate J. Leukoc. Biol., 2017-06-21;0(0):. 2017-06-21 [PMID: 28637896] (Flow Cytometry, Human)	Flow Cytometry	Human
MJ Aldape, A Tao, DD Heeney, ER McIndoo, JM French, D Xu Experimental identification and computational characterization of a novel extracellular metalloproteinase produced by Clostridium sordellii RSC Adv, 2017-03-02;7(23):13928-13938. 2017-03-02 [PMID: 28515901] (Western Blot)	Western Blot
James C. R. Wadkin, Daniel A. Patten, Sivesh K. Kamarajah, Emma L. Shepherd, Vera Novitskaya, Fedor Berditchevski et al. CD151 supports VCAM-1-mediated lymphocyte adhesion to liver endothelium and is upregulated in chronic liver disease and hepatocellular carcinoma American Journal of Physiology-Gastrointestinal and Liver Physiology 8/1/2017 [PMID: 28473332]
Hegde M, Mukherjee M, Grada Z, Pignata A, Landi D, Navai S, Wakefield A, Fousek K, Bielamowicz K, Chow K, Brawley V, Byrd T, Krebs S, Gottschalk S, Wels W, Baker M, Dotti G, Mamonkin M, Brenner M, Orange J, Ahmed N Tandem CAR T cells targeting HER2 and IL13Ralpha2 mitigate tumor antigen escape. J Clin Invest, 2016-07-18;126(8):3036-52. 2016-07-18 [PMID: 27427982]
Inoue-Mochita M, Inoue T, Fujimoto T, Kameda T, Awai-Kasaoka N, Ohtsu N, Kimoto K, Tanihara H p38 MAP kinase inhibitor suppresses transforming growth factor-beta2-induced type 1 collagen production in trabecular meshwork cells. PLoS ONE, 2015-03-23;10(3):e0120774. 2015-03-23 [PMID: 25799097] (ICC, Human)	ICC	Human
Onken , Michael, Li , Jinmei, Cooper , John A Uveal melanoma cells utilize a novel route for transendothelial migration. PLoS ONE, 2014-12-15;9(12):e115472. 2014-12-15 [PMID: 25506912] (ICC, Neutralization, Human)	ICC, Neutralization	Human
Roe , Kelsey, Orillo , Beverly, Verma , Saguna West Nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model. PLoS ONE, 2014-07-18;9(7):e102598. 2014-07-18 [PMID: 25036379] (Neutralization, Human)	Neutralization	Human
Spilioti E, Jaakkola M, Tolonen T, Lipponen M, Virtanen V, Chinou I, Kassi E, Karabournioti S, Moutsatsou P Phenolic acid composition, antiatherogenic and anticancer potential of honeys derived from various regions in Greece. PLoS ONE, 2014-04-21;9(4):e94860. 2014-04-21 [PMID: 24752205] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
Park , Su-Jung, Kim , Ki-Jo, Kim , Wan-Uk, Cho , Chul-Soo Interaction of mesenchymal stem cells with fibroblast-like synoviocytes via cadherin-11 promotes angiogenesis by enhanced secretion of placental growth factor. J Immunol, 2014-02-26;192(7):3003-10. 2014-02-26 [PMID: 24574497] (Neutralization, Human)	Neutralization	Human
Lin , Yi-Wen, Huang , Chun-Yao, Chen , Yung-Hsi, Shih , Chun-Min, Tsao , Nai-Wen, Lin , Cheng-Ye, Chang , Nen-Chun, Tsai , Chien-Su, Tsai , Hsiao-Ya, Tsai , Jui-Chi, Huang , Po-Hsun, Li , Chi-Yuan, Lin , Feng-Yen GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, impairs neovascularization by decreasing endothelial progenitor cell function. PLoS ONE, 2013-12-23;8(12):e84731. 2013-12-23 [PMID: 24376840] (Western Blot, Human)	Western Blot	Human
Lauridsen H, Pober J, Gonzalez A A composite model of the human postcapillary venule for investigation of microvascular leukocyte recruitment. FASEB J, 2013-12-02;28(3):1166-80. 2013-12-02 [PMID: 24297702] (ICC, Human)	ICC	Human
Macrophages induce differentiation of plasma cells through CXCL10/IP-10. J. Exp. Med., 2012-09-17;209(10):1813-23. 2012-09-17 [PMID: 22987802] (Neutralization, Human)	Neutralization	Human
Benito-Miguel M, Garcia-Carmona Y, Balsa A, Bautista-Caro MB, Arroyo-Villa I, Cobo-Ibanez T, Bonilla-Hernan MG, De Ayala CP, Sanchez-Mateos P, Martin-Mola E, Miranda-Carus ME IL-15 Expression on RA Synovial Fibroblasts Promotes B Cell Survival. PLoS ONE, 2012-07-09;7(7):e40620. 2012-07-09 [PMID: 22792388] (Neutralization, Human)	Neutralization	Human
Lon D. Ridgway, Michael D. Wetzel, Jason A. Ngo, Anat Erdreich-Epstein, Dario Marchetti Heparanase – induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells Molecular Cancer Research 6/1/2012 [PMID: 22513363]
Yue Zhao, Deborah A. Howatt, Florence Gizard, Takashi Nomiyama, Hannes M. Findeisen, Elizabeth B. Heywood et al. Deficiency of the NR4A Orphan Nuclear Receptor NOR1 Decreases Monocyte Adhesion and Atherosclerosis Circulation Research 8/20/2010 [PMID: 20558821]
Crosby HA, Lalor PF, Ross E, Newsome PN, Adams DH Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4. J. Hepatol., 2009-07-30;51(4):734-49. 2009-07-30 [PMID: 19703720] (IHC, Neutralization, Human)	IHC, Neutralization	Human
Smedlund K, Vazquez G Involvement of native TRPC3 proteins in ATP-dependent expression of VCAM-1 and monocyte adherence in coronary artery endothelial cells. Arterioscler. Thromb. Vasc. Biol., 2008-09-11;28(11):2049-55. 2008-09-11 [PMID: 18787184] (ELISA Development, Human)	ELISA Development	Human
Ylostalo J, Bazhanov N, Prockop DJ Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies. Exp. Hematol., 2008-07-10;36(10):1390-402. 2008-07-10 [PMID: 18619725] (ICC, Human)	ICC	Human
Kang YM, Kim SY, Kang JH LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes. Arthritis Rheum., 2007-04-01;56(4):1106-17. 2007-04-01 [PMID: 17393389] (Western Blot, Human)	Western Blot	Human
Rajesh M, Mukhopadhyay P, Batkai S, Hasko G, Liaudet L, Drel VR, Obrosova IG, Pacher P Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. Am. J. Physiol. Heart Circ. Physiol., 2007-03-23;293(1):H610-9. 2007-03-23 [PMID: 17384130] (Western Blot, Human)	Western Blot	Human
Coupel S, Moreau A, Hamidou M, Horejsi V, Soulillou JP, Charreau B Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation. Blood, 2007-04-01;109(7):2806-14. 2007-04-01 [PMID: 17179229] (Western Blot, Human)	Western Blot	Human
Kelly KA, Allport JR, Yu AM, Sinh S, Sage EH, Gerszten RE, Weissleder R SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration. J. Leukoc. Biol., 2006-12-18;81(3):748-56. 2006-12-18 [PMID: 17178915] (Functional Assay, Human)	Functional Assay	Human
Fitau J, Boulday G, Coulon F, Quillard T, Charreau B The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways. J. Biol. Chem., 2006-04-27;281(29):20148-59. 2006-04-27 [PMID: 16644735] (Western Blot, Human)	Western Blot	Human
Ramachandran R, Morice AH, Compton SJ Proteinase-activated receptor2 agonists upregulate granulocyte colony-stimulating factor, IL-8, and VCAM-1 expression in human bronchial fibroblasts. Am. J. Respir. Cell Mol. Biol., 2006-02-23;35(1):133-41. 2006-02-23 [PMID: 16498082] (Flow Cytometry, Human)	Flow Cytometry	Human
Yamamoto H, Nagata M, Sakamoto Y CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1. Ann. Allergy Asthma Immunol., 2005-02-01;94(2):292-300. 2005-02-01 [PMID: 15765748] (ELISA Development, ICC, Human)	ELISA Development, ICC	Human
Lawson C, Ainsworth M, Yacoub M, Rose M Ligation of ICAM-1 on endothelial cells leads to expression of VCAM-1 via a nuclear factor-kappaB-independent mechanism. J. Immunol., 1999-03-01;162(5):2990-6. 1999-03-01 [PMID: 10072550] (Western Blot, Human)	Western Blot	Human
Abe Y, Ballantyne CM, Smith CW Functions of domain 1 and 4 of vascular cell adhesion molecule-1 in alpha4 integrin-dependent adhesion under static and flow conditions are differentially regulated. J. Immunol., 1996-12-01;157(11):5061-9. 1996-12-01 [PMID: 8943415] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Show All 46 Publications. Collapse Publications.

VCAM-1/CD106 Antibody (BBIG-V1) [Unconjugated]

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	Verified Customer 01/20/2015
Application:	IF
Species:	Human