Urocortin Antibody (749606)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Urocortin (UCN, UCN1) is a member of the widely expressed corticotropin releasing factor (CRF) peptide family that includes UCN1-3 and CRF. UCN stimulates cAMP and MAPK pathways via either of two G-protein coupled receptors, CRFR1 and CRFR2, while other family members prefer CRFR1 (CRF) or CRFR2 (UCN2, UCN3). In the brain, UCN has been implicated in counteracting stress-provoked anxiety and suppressing appetite. It also modulates metabolic activity in peripheral tissues and protects the heart from ischemia/reprofusion injury. The UCN cDNA encodes 124 aa, including a 25 aa signal sequence, a 57 aa propeptide, and a 42 aa mature active 5 kDa UCN peptide. The proform of human UCN (aa 26-124, 11 kDa predicted) shares approximately 80% aa sequence identity with mouse and rat UCN.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 2 of 2.

Publications using MAB7447	Applications	Species
JF Jhang, LA Birder, YH Jiang, YH Hsu, HC Ho, HC Kuo Dysregulation of bladder corticotropin-releasing hormone receptor in the pathogenesis of human interstitial cystitis/bladder pain syndrome Sci Rep, 2019-12-16;9(1):19169. 2019-12-16 [PMID: 31844086] (Western Blot, Human)	Western Blot	Human
GL Owens, KM Lawrence, TR Jackson, EJ Crosbie, BS Sayan, HC Kitchener, PA Townsend Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen Cancer Med, 2017-01-21;0(0):. 2017-01-21 [PMID: 28109061] (Western Blot, Human)	Western Blot	Human

Array MAB7447

• Urocortin Antibodies