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Recombinant Human C1qTNF14/C1qL1 Protein, CF

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When Recombinant Human C1qTNF14/C1qL1 (Catalog # 9134-TN) is coated at 1 µg/mL (100 μL/well), Recombinant Human BAI3 (Catalog # (Catalog # 9106-BA) binds with a typical ED50 of 0.4-2.4 μg/mL.
When Recombinant Human C1qTNF14/C1qL1 (Catalog # 9134-TN) is coated at 1 µg/mL (100 μL/well), Recombinant Human BAI3 (Catalog # (Catalog # 9106-BA) binds with a typical ED50 of 0.4-2.4 μg/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

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Recombinant Human C1qTNF14/C1qL1 Protein, CF Summary

Details of Functionality
Measured by its binding ability in a functional ELISA. When Recombinant Human C1qTNF14/C1qL1 is immobilized at 1 μg/mL, 100 μL/well, the concentration of Recombinant Human BAI3 (Catalog # 9106-BA) that produces 50% of the optimal binding response is approximately 0.4-2.4 μg/mL
Source
E. coli-derived human C1qL1 protein
Thr125-Asp258, with an N-terminal Met and 6-His tag
Accession #
N-terminal Sequence
Met
Structure / Form
Noncovalently-linked homotrimer
Protein/Peptide Type
Recombinant Proteins
Gene
C1ql1
Purity
>85%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity
Theoretical MW
16 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
13 kDa, reducing conditions

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in Tris, NaCl and TCEP.
Purity
>85%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 1 mg/mL in water.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human C1qTNF14/C1qL1 Protein, CF

  • C1qL1
  • C1q-related factor
  • C1QRF
  • C1QRFCRFC1QTNF14
  • C1qTNF14
  • Complement component 1 Q subcomponent-like 1
  • complement component 1, q subcomponent-like 1
  • CTRP14

Background

C1qTNF14 (CTRP14), also known as C1qL1, is an approximately 30 kDa member of the C1q family of secreted proteins (1, 2). Mature human C1qTNF14 contains a collagen-like region and one C1q-like domain and can form disulfide-linked heteromers with C1qTNF11/C1qL4 (3, 4). Within the C1q-like domain, human C1qTNF14 shares 100% aa sequence identity with mouse and rat C1qTNF14. C1qTNF14 is expressed in the inferior olive, hippocampus, and cerebral cortex (5). Similarly to C1qTNF13/C1qL3, C1qTNF10/C1qL2, and C1qTNF11/C1qL4, C1qTNF14 binds to BAI3 in the cerebral cortex and on cerebellar Purkinje cells (5-8). C1qTNF14/C1qL1 binding to BAI3 induces the formation and maintenance of excitatory synapses between climbing fibers and parallel fibers with Purkinje cells (5, 7).
  1. Grebrehiwet, B. et al. (2012) Front. Immunol. 5:3.
  2. Yuzaki, M. (2010) Eur. J. Neurosci. 32:191.
  3. Ressl, S. et al. (2015) Structure 23:688.
  4. Wei, Z. et al. (2013) J. Biol. Chem. 288:10214.
  5. Sigoillot, S.M. et al. (2015) Cell Rep. 10:820.
  6. Lanoue, V. et al. (2013) Mol. Psychiatry 18:943.
  7. Kakegawa, W. et al. (2015) Neuron 85:316.
  8. Bolliger, M.F. et al. (2011) Proc. Natl. Acad. Sci. USA 108:2534.

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Bioinformatics

Gene Symbol C1ql1
Uniprot