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UCH-L1/PGP9.5 Antibody (31A3) [FITC]

 
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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Ca, ZeSpecies Glossary
Applications WB, Simple Western, Flow, ICC/IF, IHC
Clone
31A3
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-33130AF350
Alexa Fluor 405
NBP2-33130AF405
Alexa Fluor 488
NBP2-33130AF488
Alexa Fluor 532
NBP2-33130AF532
Alexa Fluor 594
NBP2-33130AF594
Alexa Fluor 647
NBP2-33130AF647
Alexa Fluor 700
NBP2-33130AF700
Alexa Fluor 750
NBP2-33130AF750
Allophycocyanin
NBP2-33130APC
Biotin
NBP2-33130B-100ul
DyLight 350
NBP2-33130UV-100ul
DyLight 405
NBP2-33130V-100ul
DyLight 488
NBP2-33130G-100ul
DyLight 550
NBP2-33130R-100ul
DyLight 594
NBP2-33130DL594
DyLight 650
NBP2-33130C-100ul
DyLight 680
NBP2-33130FR-100ul
DyLight 755
NBP2-33130IR-100ul
HRP
NBP2-33130H-100ul
Janelia Fluor 549
NBP2-33130JF549
Janelia Fluor 646
NBP2-33130JF646
PE
NBP2-33130PE
PerCP
NBP2-33130PCP
Unconjugated
NB600-1160
mFluor Violet 450 SE
NBP2-33130MFV450
mFluor Violet 500 SE
NBP2-33130MFV500
mFluor Violet 610 SE
NBP2-33130MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB600-1160
Azide and BSA Free
NBP2-33130
IHC-Prediluted
NBP2-45339
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UCH-L1/PGP9.5 Antibody (31A3) [FITC] Summary

Immunogen
UCH-L1/PGP9.5 protein from brain (Uniprot: P09936)
Localization
Cytoplasmic, Endoplasmic Reticulum membrane
Marker
pan-Neuronal Marker
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
UCHL1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Zebrafish reactivity reported in scientific literature (PMID: 30377377).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for UCH-L1/PGP9.5 Antibody (31A3) [FITC]

  • EC 3.4.19.12
  • EC 6.-
  • Neuron cytoplasmic protein 9.5
  • PARK5
  • PGP 9.5
  • PGP9.5
  • PGP9.5Uch-L1
  • PGP95
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
  • ubiquitin carboxyl-terminal hydrolase isozyme L1
  • ubiquitin C-terminal hydrolase
  • Ubiquitin thioesterase L1
  • UCHL1
  • UCH-L1

Background

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a soluble cytoplasmic protein found in neurons and in cells of the diffuse neuroendocrine system, and their respective tumors. Therefore, UCH-L1 has been widely used as a peripheral nerve fiber marker. UCHL-1 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme involved in the processing of both ubiquitin precursors and ubiquitinated proteins.

UCH L1 is down-regulated in brains from Parkinson disease and Alzheimer disease patients, and certian site specific mutations in the UCHL1 gene can either increase or decrese the risk of Parkinson's and/or Alzheimer's neurodegenerative diseases.

Human UCHL 1 and the closely related UCHL3 protein have one of the most complicated knot structures ever discovered, with five knot crossings. This knot structure is expected to help the protein resist degradation in the proteasome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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UCH-L1/PGP9.5
Antibody (31A3) [FITC
NBP2-33130F
UCH-L1/PGP9.5 Antibody (31A3) [FITC]
Species: Hu, Mu, Rt, Po, Bv, Ca, Ze
Applications: WB, Simple Western, Flow, ICC/IF, IHC

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Bioinformatics

Gene Symbol UCHL1