UCH-L1/PGP9.5 Antibody (13C4)

PGP9.5 (protein gene product 9.5), also known as UchL1 (ubiquitin C-terminal hydrolase) and PARK5, is a neuronal biomarker and ubquitin system protein (reviewed in Day and Thompson, 2010). PGP9.5 is a highly conserved protein and has shown that it is expressed in neurons and neuroendocrine cells in vertebrates where it comprises about 5-10% of soluble cytoplasmic proteins. A minor proportion of PGP9.5 in brain is tightly bound to the membrane. PGP9.5 is also expressed in human oocytes and spermatogonia. It is important to note that the use of an antibody as a biomarker in this case does not imply that an antibody defines absolute tissue specificity. Rather, it means that PGP9.5 is expressed in neurons and neuroendrocine cells at significantly higher levels than in other cell types.
A mutation in the UchL1 gene has been found to cause a form of Parkinson's disease, and this discovery has spurred considerable research interest in UchL1 and to its alternative name of PARK5.
Antibody to UchL1 is widely used as an immunohistochemical marker of nerves and neuroendocrine cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IHC, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using NBP2-29420	Applications	Species
Tu N, Inoue K, Lewis P et al. Calcitonin Related Polypeptide Alpha Mediates Oral Cancer Pain Cells 2023-06-21 [PMID: 37443709] (IHC, Mouse)	IHC	Mouse
Zhang D, Hao W, Niu Q et al. Identification of the co-differentially expressed hub genes involved in the endogenous protective mechanism against ventilator-induced diaphragm dysfunction Skeletal Muscle 2022-09-09 [PMID: 36085166] (Western Blot)	Western Blot
Zhang D, Hao W, Li X et al. Aldh1a1 and Scl25a30 in diaphragmatic dysfunction Experimental biology and medicine (Maywood, N.J.) 2022-04-11 [PMID: 35410502]
Gaunitz C, Gabert J, Lucker E et al. Suitability of antigens PGP 9.5 and neurofilament light as marker proteins for detection of neuronal tissue in processed meat products. J Food Prot. 2009-05-01 [PMID: 19517736] Details: Sandwich ELISA (cow and pig meat). PGP9.5 antibodies from clones 13C4 and 31A3 were used to detect neuronal contaminant components in meat. Refer to the publication for additional details.

Array NBP2-29420

• UCH-L1/PGP9.5 Antibodies
• UCH-L1/PGP9.5 Lysate
• UCH-L1/PGP9.5 Proteins
• UCH-L1/PGP9.5 ELISA
• UCH-L1/PGP9.5 Proteins and Enzyme