TRPM7 Antibody - Azide and BSA Free

TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.; FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).; CATALYTIC ACTIVITY: ATP + a protein: ADP + a phosphoprotein.; COFACTOR: Binds 1 zinc ion per subunit.; SUBUNIT: Homodimer. Forms heterodimers with TRPM6.; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 applications: Block/Neutralize, IF/IHC, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-20224	Applications	Species
Andriul? I, Pangonyt? D, Gwanyanya A et al. Detection of TRPM6 and TRPM7 Proteins in Normal and Diseased Cardiac Atrial Tissue and Isolated Cardiomyocytes International Journal of Molecular Sciences 2022-11-28 [PMID: 36499188] (Block/Neutralize)	Block/Neutralize
Andriule I, Pangonyte D, Almanaityte M Et Al. Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart Scientific reports 2021-07-29 [PMID: 34326388] (IF/IHC)	IF/IHC
Yang Y, Cai Y, Zhang Y et al. Exosomes Secreted by Adipose-Derived Stem Cells Contribute to Angiogenesis of Brain Microvascular Endothelial Cells Following Oxygen-Glucose Deprivation In Vitro Through MicroRNA-181b/TRPM7 Axis J. Mol. Neurosci. 2018-05-01 [PMID: 29705934] (WB)	WB

Array NBP1-20224

• TRPM7 Antibodies
• TRPM7 Proteins