TRPM3 Antibody

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. FUNCTION: Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using NB100-98864	Applications	Species
Shaffer FJ Vagal Afferent Neurotransmission: Effects of Circadian Rhythms, Adrenal Steroids, and TRP Channel Activity Thesis 2021-01-01
Ragozzino FJ, Arnold RA, Fenwick AJ et al. TRPM3 expression and control of glutamate release from primary vagal afferent neurons Journal of neurophysiology 2020-12-09 [PMID: 33296617]
Aoki R, Yokoyama U, Ichikawa Y et al. Decreased serum osmolality promotes ductus arteriosus constriction. Cardiovasc. Res. 2014-09-04 [PMID: 25190043]

Array NB100-98864

• TRPM3 Antibodies
• TRPM3 Lysate
• TRPM3 Proteins