Annexin A1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The Annexins are a family of Calcium-dependent phospholipid-binding proteins that are preferentially located on the cytosolic face of the plasma membrane. The Annexin’s have a molecular weight of approximately 35 to 40 kDa and consist of a unique amino terminal domain followed by a homologous C-terminal core domain containing the calcium-dependent phospholipid-binding sites. The C‑terminal domain is comprised of four 60‑70 amino acid repeats, known as annexin repeats or an endonexin fold (Annexin A6 contains 8 annexin repeats). The four annexin repeats form a highly alpha -helical, tightly packed disc known as the annexin domain, which binds to phospholipids in the membrane in a calcium-dependent manner. Members of the annexin family play a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways. Annexin A1 (ANXA1), also known as annexin I, lipocortin I, and calpactin II, is an ~ 40 kDa protein with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, Annexin A1 may have anti-inflammatory activity. Human Annexin A1 shares 88 and 89% identity with mouse and rat Annexin A1, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ICC, IHC, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using AF3770	Applications	Species
W Zhang, G Yin, H Zhao, H Ling, Z Xie, C Xiao, Y Chen, Y Lin, T Jiang, S Jin, J Wang, X Yang Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner Cell Death & Disease, 2021-01-20;12(1):102. 2021-01-20 [PMID: 33473125] (IHC, Human)	IHC	Human
Cao J, O'Day DR, Pliner HA et al. A human cell atlas of fetal gene expression Science 11/13/2020 [PMID: 33184181]
Arseniy E. Yuzhalin, Su Yin Lim, Alex N. Gordon-Weeks, Roman Fischer, Benedikt M. Kessler, Dihua Yu et al. Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases American Journal of Physiology-Gastrointestinal and Liver Physiology 11/1/2019 [PMID: 31545917]
Gaohua Han, Kaijin Lu, Wansong Xu, Sihui Zhang, Junxing Huang, Chunlei Dai et al. Annexin A1‑mediated inhibition of inflammatory cytokines may facilitate the resolution of inflammation in acute radiation‑induced lung injury Oncology Letters 5/6/2019 [PMID: 31289503]
A Fayzullin, CJ Sandberg, M Spreadbury, BM Saberniak, Z Grieg, E Skaga, IA Langmoen, EO Vik-Mo Phenotypic and Expressional Heterogeneity in the Invasive Glioma Cells Transl Oncol, 2018-10-03;12(1):122-133. 2018-10-03 [PMID: 30292065] (ICC, Human)	ICC	Human
Santos J, Gonzalez-Sanchez L, Matabuena-Deyzaguirre M, Villa-Morales M, Cozar P, Lopez-Nieva P, Fernandez-Navarro P, Fresno M, Diaz-Munoz MD, Guenet JL, Montagutelli X, Fernandez-Piqueras J A role for stroma-derived annexin A1 as mediator in the control of genetic susceptibility to T-cell lymphoblastic malignancies through prostaglandin E2 secretion. Cancer Res., 2009-02-24;69(6):2577-87. 2009-02-24 [PMID: 19244132] (Western Blot, Mouse)	Western Blot	Mouse

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	WB	Human	01/08/2015	View Summary Application Western Blot Sample Tested See PMID 20618702 Species Human

Array AF3770

• Annexin A1 Antibodies
• Annexin A1 ELISA Kit
• Annexin A1 Lysate
• Annexin A1 Proteins
• Annexin A1 Proteins and Enzyme