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TopBP1 Antibody [Janelia Fluor® 669]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Janelia Fluor 669

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-217AF350
Alexa Fluor 405
NB100-217AF405
Alexa Fluor 488
NB100-217AF488
Alexa Fluor 532
NB100-217AF532
Alexa Fluor 594
NB100-217AF594
Alexa Fluor 647
NB100-217AF647
Alexa Fluor 700
NB100-217AF700
Alexa Fluor 750
NB100-217AF750
Allophycocyanin
NB100-217APC
Biotin
NB100-217B
CoraFluor 1
NB100-217CL1
DyLight 350
NB100-217UV
DyLight 405
NB100-217V
DyLight 488
NB100-217G
DyLight 550
NB100-217R
DyLight 594
NB100-217DL594
DyLight 650
NB100-217C
DyLight 680
NB100-217FR
DyLight 755
NB100-217IR
FITC
NB100-217F
HRP
NB100-217H
Janelia Fluor 525
NB100-217JF525
Janelia Fluor 549
NB100-217JF549
Janelia Fluor 585
NB100-217JF585
Janelia Fluor 635
NB100-217JF635
Janelia Fluor 646
NB100-217JF646
PE
NB100-217PE
PerCP
NB100-217PCP
Unconjugated
NB100-217
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TopBP1 Antibody [Janelia Fluor® 669] Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 1400 and the C-terminus (residue 1435) of human Topoisomerase (DNA) II Binding Protein 1 using the numbering given in entry NP_008958.1 (GeneID 11073).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TOPBP1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for TopBP1 Antibody [Janelia Fluor® 669]

  • DNA topoisomerase II-beta-binding protein 1
  • DNA topoisomerase II-binding protein 1
  • KIAA0259DNA topoisomerase 2-binding protein 1
  • TOP2BP1
  • TopBP1
  • topoisomerase (DNA) II binding protein 1

Background

DNA topoisomerase II-binding protein 1 (TopBP1) is a protein that interacts with the C-terminal region of topoisomerase II beta (Topo II beta). TopBP1 function has been found to be important to various aspects of cellular growth control such as DNA replication, the DNA damage checkpoint, and cell survival. TopBP1 interacts with several proteins through its BRCA1 C-terminal (BRCT) motifs. TopBP1 interacts and inhibits E2F1 transcriptional activity through an Rb-independent mechanism that involves recruitment of the SWI/SNF chromatin-remodeling complex proteins Brg1 and Brm.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol TOPBP1