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Recombinant Human TL1A/TNFSF15 Protein

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SDS-Page: Recombinant Human TL1A/TNFSF15 Protein [NBP2-35067]
SDS-Page: Recombinant Human TL1A/TNFSF15 Protein [NBP2-35067]

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE, Bioactivity
Format
Carrier-Free
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier-Free
NBP2-35067-1mg
Carrier-Free
NBP2-35067-100ug
Carrier-Free
NBP2-35067-500ug
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Recombinant Human TL1A/TNFSF15 Protein Summary

Description
A single non-glycosylated polypeptide chain containing 180 amino acids corresponding to TL1A/TNFSF15 Source: E. coli

Uniprot ID: O95150

Amino Acid Sequence: LKGQEFAPSH QQVYAPLRAD GDKPRAHLTV VRQTPTQHFK NQFPALHWEH ELGLAFTKNR MNYTNKFLLI PESGDYFIYS QVTFRGMTSE CSEIRQAGRP NKPDSITVVI TKVTDSYPEP TQLLMGTKSV CEVGSNWFQP IYLGAMFSLQ EGDKLMVNVS DISLVDYTKE DKTFFGAFLL
Details of Functionality
TL1A/TNFSF15 protein is fully biologically active when compared to standard. The ED50 as determined by its ability to induce apoptosis using human TF-1 cells is less than 20 ng/ml, corresponding to a specific activity of > 5.0 x 10^4 IU/mg
Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
TNFSF15
Purity
> 97 % pure by SDS-PAGE and HPLC
Endotoxin Note
Less than 0.1 EU/ug of TL1A/TNFSF15 as determined by LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity
  • SDS-Page
Theoretical MW
20.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles.
Buffer
Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4, with 0.02% Tween-20.
Preservative
No Preservative
Concentration
LYOPH
Purity
> 97 % pure by SDS-PAGE and HPLC
Reconstitution Instructions
Recommended to centrifuge prior to opening. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/mL.

Alternate Names for Recombinant Human TL1A/TNFSF15 Protein

  • MGC129934
  • MGC129935
  • TL1A
  • TL-1A
  • TL-1A/TNFSF15
  • TL1Vascular endothelial cell growth inhibitor
  • TNF superfamily ligand TL1A
  • TNFSF15
  • tumor necrosis factor (ligand) superfamily, member 15
  • tumor necrosis factor ligand superfamily member 15
  • vascular endothelial growth inhibitor-192A
  • VEGI
  • VEGI192A
  • VEGITNF ligand-related molecule 1

Background

TL-1A is a type II transmembrane protein belonging to the TNF superfamily and has been designated TNF superfamily member 15 (TNFSF15). TL-1A is predominantly expressed in endothelial cells and its expression is inducible by TNF-alpha and IL-1alpha. TL- 1A binds with high affinity to death receptor 3 (DR3), known as TNFRSF25. Depending on the cell context, ligation of DR3 by TL-1A can trigger one of two signaling pathways, activation of the transcription factor NF-kB, or activation of caspases and apoptosis. Recombinant human TL-1A is a 20.5 kDa polypeptide of 180 amino acid residues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Recombinant Human
TL1A/TNFSF15 Protein
NBP2-35067
Recombinant Human TL1A/TNFSF15 Protein
Species: Hu
Applications: PAGE, Bioactivity

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Bioinformatics

Gene Symbol TNFSF15
Uniprot