TL1A/TNFSF15 Products

Description

VEGI is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined

Bioinformatics

Entrez	9966 Human
Uniprot	AAM77366 Human AAR98573 Human NM_005118 Human NP_005109 Human NP_005109.2 Human O95150 Human
Product By Gene ID	9966
Alternate Names	MGC129934 MGC129935 TL1A TL1Vascular endothelial cell growth inhibitor TNF superfamily ligand TL1A tumor necrosis factor (ligand) superfamily, member 15 tumor necrosis factor ligand superfamily member 15 vascular endothelial growth inhibitor-192A VEGI192A VEGITNF ligand-related molecule 1

Research Areas for TL1A/TNFSF15

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Cycle and Replication