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TGF beta 1/2/3 Antibody (1D11R) [Unconjugated]

 (5 Publications)
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Recombinant Human TGF-beta 1 (Catalog # 240-B) inhibits Recombinant Mouse IL-4 (Catalog # 404-ML) induced proliferation in the HT-2 mouse T cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Mouse IL-4 (7.5 ng/mL) activity elicited by Recombinant Human TGF-beta 1 (1 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-TGF-beta 1, 2, 3 Monoclonal Antibody (Catalog # MAB1835R). The ND50 is typically0.25-1.25 µg/mL.Catalog # 240-B
Recombinant Human TGF-beta 1 (Catalog # 240-B) inhibits Recombinant Mouse IL-4 (Catalog # 404-ML) induced proliferation in the HT-2 mouse T cell line in a dose-dependent manner (orange line). Inhibition of Recombinant ...read more

Product Details

Summary
Reactivity All-MultiSpecies Glossary
Applications B/N
Clone
1D11R
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB1835R-SP
Carrier Free
MAB1835R-500
Carrier Free
MAB1835R-01M
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TGF beta 1/2/3 Antibody (1D11R) [Unconjugated] Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
Bovine bone-derived TGF-beta 1 and TGF-beta 2
Specificity
Detects bovine, chicken, mouse, and human TGF-beta in ELISAs and Western blots. It recognizes human TGF-beta 1, TGF-beta 2, and TGF-beta 3.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Purity Statement
Protein A or G purified from cell culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Neutralization 0.25-1.25 ug/mL
Publications
Read Publications using
MAB1835R in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TGF beta 1/2/3 Antibody (1D11R) [Unconjugated]

  • CED
  • DPD1
  • LAP
  • TGFB
  • TGFB1
  • TGF-beta 1, 2, 3
  • TGFbeta
  • transforming growth factor, beta 1

Background

TGF-beta 1, -2, and -3 are a closely related group of proteins (70‑80% sequence homology) that are produced by many cell types and function as growth and differentiation factors. The active forms of TGF-beta 1, -2, and -3 are disulfide-linked homodimers.
  1. Ayala A. et al. (1992) FASEB J. 6:A1604.
  2. Roberts A.B. and Sporn M.B., eds. (1990) Peptide Growth Factors and Their Receptors I, Springer-Verlag, 419.
  3. Dasch J.R. et al. (1989) J. Immunol. 142:1536.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TGF beta 1/2/3
Antibody (1D11R) [Unc ...
MAB1835R
TGF beta 1/2/3 Antibody (1D11R) [Unconjugated]
Species: All-Multi
Applications: B/N

Publications for TGF beta 1/2/3 Antibody (MAB1835R)(5)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Cell Culture, Functional Assay, Neutralization.


Filter By Application
Cell Culture
(1)
Functional Assay
(1)
Neutralization
(2)
All Applications
Filter By Species
Human
(2)
Mouse
(2)
All Species
Showing Publications 1 - 5 of 5.
Publications using MAB1835R Applications Species
ER Trzeciak, N Zimmer, PW Kämmerer, D Thiem, B Al-Nawas, A Tuettenber, S Blatt GARP Regulates the Immune Capacity of a Human Autologous Platelet Concentrate Biomedicines, 2022-12-05;10(12):. 2022-12-05 [PMID: 36551892] (Functional Assay, Human) Functional Assay Human
A Okubo, Y Uchida, Y Higashi, T Sato, Y Ogawa, A Ryuge, K Kadomatsu, T Kanekura CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation International Journal of Molecular Sciences, 2021-12-24;23(1):. 2021-12-24 [PMID: 35008603] (Neutralization, Mouse) Neutralization Mouse
N Zimmer, FK Krebs, S Zimmer, H Mitzel-Rin, EJ Kumm, K Jurk, S Grabbe, C Loquai, A Tuettenber Platelet-Derived GARP Induces Peripheral Regulatory T Cells-Potential Impact on T Cell Suppression in Patients with Melanoma-Associated Thrombocytosis Cancers, 2020-12-05;12(12):. 2020-12-05 [PMID: 33291452] (Cell Culture, Human) Cell Culture Human
Y Zhao, J Wang, Z Min, L Peng, S Qi, W Lin I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis Mediators Inflamm., 2020-03-10;2020(0):6947482. 2020-03-10 [PMID: 32256194] (Neutralization, Mouse) Neutralization Mouse
Tian Zhou, Yiming Zheng, Li Sun, Smaranda Ruxandra Badea, Yuanhu Jin, Yang Liu et al. Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury Nature Neuroscience 3/1/2019 [PMID: 30664769]

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Secondary Antibodies

 

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