Jeong, H;Koh, J;Kim, S;Song, SG;Lee, SH;Jeon, Y;Lee, CH;Keam, B;Lee, SH;Chung, DH;Jeon, YK; Epithelial-mesenchymal transition induced by tumor cell-intrinsic PD-L1 signaling predicts a poor response to immune checkpoint inhibitors in PD-L1-high lung cancer British journal of cancer 2024-05-10 [PMID: 38729997] (Neutralization, Human) |
Neutralization |
Human |
Seller, A;Tegeler, CM;Mauermann, J;Schreiber, T;Hagelstein, I;Liebel, K;Koch, A;Heitmann, JS;Greiner, SM;Hayn, C;Dannehl, D;Engler, T;Hartkopf, AD;Hahn, M;Brucker, SY;Salih, HR;Märklin, M; Soluble NKG2DLs Are Elevated in Breast Cancer Patients and Associate with Disease Outcome International journal of molecular sciences 2024-04-08 [PMID: 38612935] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
Kostadinova, R;Ströbel, S;Chen, L;Fiaschetti-Egli, K;Gadient, J;Pawlowska, A;Petitjean, L;Bieri, M;Thoma, E;Petitjean, M; Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model Scientific reports 2024-03-11 [PMID: 38467661] (Bioassay, Human) |
Bioassay |
Human |
Petillo, S;Sproviero, E;Loconte, L;Cuollo, L;Zingoni, A;Molfetta, R;Fionda, C;Soriani, A;Cerboni, C;Petrucci, MT;Fazio, F;Paolini, R;Santoni, A;Cippitelli, M; NEDD8-activating enzyme inhibition potentiates the anti-myeloma activity of natural killer cells Cell death & disease 2023-07-17 [PMID: 37460534] (Neutralization) |
Neutralization |
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Michielon, E;López González, M;Stolk, DA;Stolwijk, JGC;Roffel, S;Waaijman, T;Lougheed, SM;de Gruijl, TD;Gibbs, S; A Reconstructed Human Melanoma-in-Skin Model to Study Immune Modulatory and Angiogenic Mechanisms Facilitating Initial Melanoma Growth and Invasion Cancers 2023-05-20 [PMID: 37345186] (Neutralization, Human) |
Neutralization |
Human |
Marvin, DL;Dijkstra, J;Zulfiqar, RM;Vermeulen, M;Ten Dijke, P;Ritsma, L; TGF-? Type I Receptor Signaling in Melanoma Liver Metastases Increases Metastatic Outgrowth International journal of molecular sciences 2023-05-12 [PMID: 37240029] (Neutralization, Mouse) |
Neutralization |
Mouse |
Carneiro, CS;Hapeman, JD;Nedelcu, AM; Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones BMC ecology and evolution 2023-05-24 [PMID: 37226092] (Bioassay, Human) |
Bioassay |
Human |
S Vondra, AL Höbler, AI Lackner, J Raffetsede, ZN Mihalic, A Vogel, L Saleh, V Kunihs, P Haslinger, M Wahrmann, H Husslein, R Oberle, J Kargl, S Haider, P Latos, G Schabbauer, M Knöfler, J Ernerudh, J Pollheimer The human placenta shapes the phenotype of decidual macrophages Cell Reports, 2023-01-10;42(1):111977. 2023-01-10 [PMID: 36640334] (Neutralization, Human) |
Neutralization |
Human |
Cinzia Fionda, Silvia Ruggeri, Giuseppe Sciumè, Mattia Laffranchi, Isabella Quinti, Cinzia Milito et al. Age-dependent NK cell dysfunctions in severe COVID-19 patients Frontiers in Immunology 11/17/2022 [PMID: 36466890] |
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SI Gringhuis, TM Kaptein, EBM Remmerswaa, A Drewniak, BA Wevers, B Theelen, GRAM D'Haens, T Boekhout, TBH Geijtenbee Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs Nature Immunology, 2022-12-01;0(0):. 2022-12-01 [PMID: 36456734] (ELISA Capture, Human) |
ELISA Capture |
Human |
W Zeng, L Xiong, W Wu, S Li, J Liu, L Yang, L Lao, P Huang, M Zhang, H Chen, N Miao, Z Lin, Z Liu, X Yang, J Wang, P Wang, E Song, Y Yao, Y Nie, J Chen, D Huang CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype Oncogene, 2022-11-22;0(0):. 2022-11-22 [PMID: 36418470] (Neutralization, Human) |
Neutralization |
Human |
A Nawaz, M Bilal, S Fujisaka, T Kado, MR Aslam, S Ahmed, K Okabe, Y Igarashi, Y Watanabe, T Kuwano, K Tsuneyama, A Nishimura, Y Nishida, S Yamamoto, M Sasahara, J Imura, H Mori, MM Matzuk, F Kudo, I Manabe, A Uezumi, T Nakagawa, Y Oishi, K Tobe Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration Nature Communications, 2022-11-21;13(1):7058. 2022-11-21 [PMID: 36411280] (ICC, Mouse) |
ICC |
Mouse |
LAG Maldonado, CR Nascimento, NAR Fernandes, ALP Silva, NJ D'Silva, C Rossa Influence of tumor cell-derived TGF-beta on macrophage phenotype and macrophage-mediated tumor cell invasion The international journal of biochemistry & cell biology, 2022-11-04;153(0):106330. 2022-11-04 [PMID: 36343916] (Neutralization, Human) |
Neutralization |
Human |
Masaki Takahashi, Yoshifumi Hashimoto, Yoshikazu Nakamura Anti-TGF-beta 1 aptamer enhances therapeutic effect of tyrosine kinase inhibitor, gefitinib, on non-small cell lung cancer in xenograft model Molecular Therapy - Nucleic Acids 2022-09-13 [PMID: 36189081] |
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Z Shen, W Luo, B Tan, K Nie, M Deng, S Wu, M Xiao, X Wu, X Meng, T Tong, C Zhang, K Ma, Y Liao, J Xu, X Wang Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease EBioMedicine, 2022-09-28;85(0):104285. 2022-09-28 [PMID: 36182776] (Neutralization, Mouse) |
Neutralization |
Mouse |
T Otsuki, N Fukuda, L Chen, A Tsunemi, M Abe Twist-related protein 1 induces epithelial-mesenchymal transition and renal fibrosis through the upregulation of complement 3 PLoS ONE, 2022-08-26;17(8):e0272917. 2022-08-26 [PMID: 36018840] (IHC, Mouse) |
IHC |
Mouse |
J Hanna, F Beke, LM O'Brien, C Kapeni, HC Chen, V Carbonaro, AB Kim, K Kishore, TE Adolph, MO Skjoedt, K Skjoedt, M de la Roch, M de la Roch Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity Nature Communications, 2022-07-14;13(1):4075. 2022-07-14 [PMID: 35835905] (Neutralization, Mouse) |
Neutralization |
Mouse |
GN Yin, DK Kim, JI Kang, Y Im, DS Lee, AR Han, J Ock, MJ Choi, MH Kwon, A Limanjaya, SB Jung, J Yang, KW Min, J Yun, Y Koh, JE Park, D Hwang, JK Suh, JK Ryu, HM Kim Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function Experimental & Molecular Medicine, 2022-05-13;0(0):. 2022-05-13 [PMID: 35562586] (Neutralization, Human) |
Neutralization |
Human |
Jiatong Liu, Jun Zhang, Xi Lin, Brendan F. Boyce, Hengwei Zhang, Lianping Xing Age-associated callus senescent cells produce TGF-beta 1 that inhibits fracture healing in aged mice Journal of Clinical Investigation 2022-04-15 [PMID: 35426372] |
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Decha Pinkaew, Erik Martinez-Hackert, Wei Jia, Matthew D. King, Fei Miao, Nicole R. Enger et al. Fortilin interacts with TGF-beta 1 and prevents TGF-beta receptor activation Communications Biology 2/23/2022 [PMID: 35197550] |
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Martina Svenja Lutz, Boris Klimovich, Stefanie Maurer, Jonas S Heitmann, Melanie Märklin, Latifa Zekri et al. Platelets subvert antitumor efficacy of T cell-recruiting bispecific antibodies Journal for ImmunoTherapy of Cancer 2022-02-02 [PMID: 35110356] |
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Jia He, Yue Du, Gaopeng Li, Peng Xiao, Xingzheng Sun, Wenjun Song et al. Myeloid Fbxw7 Prevents Pulmonary Fibrosis by Suppressing TGF-beta Production Frontiers in Immunology 2022-01-05 [PMID: 35069531] |
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Bartijn C. H. Pieters, Onno J. Arntz, Joyce Aarts, Anouk L. Feitsma, R. J. Joost van Neerven, Peter M. van der Kraan et al. Bovine Milk‐Derived Extracellular Vesicles Inhibit Catabolic and Inflammatory Processes in Cartilage from Osteoarthritis Patients Molecular Nutrition & Food Research 3/1/2022 [PMID: 34965027] |
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D Basak, Z Jamal, A Ghosh, PK Mondal, P Dey Talukd, S Ghosh, B Ghosh Roy, R Ghosh, A Halder, A Chowdhury, GK Dhali, BK Chattopadh, ML Saha, A Basu, S Roy, C Mukherjee, NK Biswas, U Chatterji, S Datta Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis PLoS ONE, 2021-08-11;16(8):e0255915. 2021-08-11 [PMID: 34379688] (Co-IP, Western Blot, Human) |
Co-IP, Western Blot |
Human |
Maria E. C. Bruno, Sujata Mukherjee, Arnold J. Stromberg, Hiroshi Saito, Marlene E. Starr Visceral fat‐specific regulation of plasminogen activator inhibitor‐1 in aged septic mice Journal of Cellular Physiology 2022-01-01 [PMID: 34369600] |
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G Mestrallet, F Auvré, C Schenowitz, ED Carosella, J LeMaoult, MT Martin, N Rouas-Frei, NO Fortunel Human Keratinocytes Inhibit CD4+ T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints Cells, 2021-06-08;10(6):. 2021-06-08 [PMID: 34201301] (Neutralization, Human) |
Neutralization |
Human |
Laura Duffy, John Henderson, Max Brown, Stefan Pryzborski, Nicola Fullard, Lena Summa et al. Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis Frontiers in Cell and Developmental Biology 2021-06-04 [PMID: 34150776] |
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RJ Playford, MJ Weiser, T Marchbank Methods to improve efficacy of orally administered bioactive peptides using bovine colostrum as an exemplar PLoS ONE, 2021-06-17;16(6):e0253422. 2021-06-17 [PMID: 34138960] (ELISA Capture, Bovine) |
ELISA Capture |
Bovine |
KV Manian, CA Galloway, S Dalvi, AA Emanuel, JA Mereness, W Black, L Winschel, C Soto, Y Li, Y Song, W DeMaria, A Kumar, I Slukvin, MP Schwartz, WL Murphy, B Anand-Apte, M Chung, DSW Benoit, R Singh 3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration Cell Stem Cell, 2021-03-29;0(0):. 2021-03-29 [PMID: 33784497] (ICC, Human) |
ICC |
Human |
MR Patel, AM Weaver Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-&beta signaling Cell Reports, 2021-03-09;34(10):108829. 2021-03-09 [PMID: 33691102] (Dot Blot, Western Blot, Rat) |
Dot Blot, Western Blot |
Rat |
QS Liang, JG Xie, C Yu, Z Feng, J Ma, Y Zhang, D Wang, J Lu, R Zhuang, J Yin Splenectomy improves liver fibrosis via tumor necrosis factor superfamily 14 (LIGHT) through the JNK/TGF-&beta1 signaling pathway Experimental & Molecular Medicine, 2021-03-03;0(0):. 2021-03-03 [PMID: 33654222] (Neutralization, Mouse) |
Neutralization |
Mouse |
Zhan‐Wen Liang, Xin‐Xin Ge, Meng‐Dan Xu, Hualong Qin, Meng‐Yao Wu, Meng Shen et al. Tumor‐associated macrophages promote the metastasis and growth of non‐small‐cell lung cancer cells through NF‐ kappa B/PP2Ac‐positive feedback loop Cancer Science 2021-06-01 [PMID: 33609307] |
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H Ungefroren, H Otterbein, UF Wellner, T Keck, H Lehnert, JU Marquardt RAC1B Regulation of TGFB1 Reveals an Unexpected Role of Autocrine TGF&beta1 in the Suppression of Cell Motility Cancers, 2020-11-29;12(12):. 2020-11-29 [PMID: 33260366] (Neutralization, Human) |
Neutralization |
Human |
Sonia Iyer, Shuang Zhang, Simge Yucel, Heiko Horn, Sean G. Smith, Ferenc Reinhardt et al. Genetically defined syngeneic mouse models of ovarian cancer as tools for the discovery of combination immunotherapy. Cancer Discovery 2021-02-01 [PMID: 33158843] |
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Stephen P. Evanko, Michel D. Gooden, Inkyung Kang, Christina K. Chan, Robert B. Vernon, Thomas N. Wight A Role for HAPLN1 During Phenotypic Modulation of Human Lung Fibroblasts In Vitro Journal of Histochemistry & Cytochemistry 2020-11-01 [PMID: 33064036] |
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Irina G. Luzina, Rita Fishelevich, Brian S. Hampton, Jean-Paul Courneya, Francesca R. Parisella, Katerina N. Lugkey et al. Full-length IL-33 regulates Smad3 phosphorylation and gene transcription in a distinctive AP2-dependent manner Cellular Immunology 2020-11-01 [PMID: 32977155] |
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Mahmoud Elashiry, Mohamed M. Elashiry, Ranya Elsayed, Mythily Rajendran, Carol Auersvald, Rana Zeitoun et al. Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo Journal of Extracellular Vesicles 2020-09-01 [PMID: 32944183] |
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AP Gomes, D Ilter, V Low, JE Endress, J Fernández-, A Rosenzweig, T Schild, D Broekaert, A Ahmed, M Planque, I Elia, J Han, C Kinzig, E Mullarky, AP Mutvei, J Asara, R de Cabo, LC Cantley, N Dephoure, SM Fendt, J Blenis Age-induced accumulation of methylmalonic acid promotes tumour progression Nature, 2020-08-19;0(0):. 2020-08-19 [PMID: 32814897] (Neutralization, Human) |
Neutralization |
Human |
LF Campesato, S Budhu, J Tchaicha, CH Weng, M Gigoux, IJ Cohen, D Redmond, L Mangarin, S Pourpe, C Liu, R Zappasodi, D Zamarin, J Cavanaugh, AC Castro, MG Manfredi, K McGovern, T Merghoub, JD Wolchok Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine Nat Commun, 2020-08-11;11(1):4011. 2020-08-11 [PMID: 32782249] (Flow Cytometry, Mouse) |
Flow Cytometry |
Mouse |
Sabrina Sapski, Nadine Beha, Roland E. Kontermann, Dafne Müller Influence of antigen density and immunosuppressive factors on tumor-targeted costimulation with antibody-fusion proteins and bispecific antibody-mediated T cell response Cancer Immunology, Immunotherapy 2020-11-01 [PMID: 32504247] |
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Deepak A Kaji, Kristen L Howell, Zerina Balic, Dirk Hubmacher, Alice H Huang Tgf beta signaling is required for tenocyte recruitment and functional neonatal tendon regeneration eLife 2020-06-05 [PMID: 32501213] |
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W Li, AS Elshikha, C Cornaby, X Teng, G Abboud, J Brown, X Zou, L Zeumer-Spa, B Robusto, SC Choi, K Fredenburg, A Major, L Morel T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice JCI Insight, 2020-06-04;5(11):. 2020-06-04 [PMID: 32493841] (Bioassay, Transgenic Mouse) |
Bioassay |
Transgenic Mouse |
E Rodríguez-, JA Navarro-Ga, J Aceves-Rip, J Abarca-Zab, A Susmozas-S, T Bada-Bosch, E Hernández, E Mérida-Her, A Andrés, M Praga, M Fernández-, JM Aguado, J Segura, LM Ruilope, G Ruiz-Hurta Variations in Circulating Active MMP-9 Levels During Renal Replacement Therapy Biomolecules, 2020-03-26;10(4):. 2020-03-26 [PMID: 32225016] (Human) |
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Human |
F Qin, X Liu, J Chen, S Huang, W Wei, Y Zou, X Liu, K Deng, S Mo, J Chen, X Chen, Y Huang, W Liang Anti-TGF-&beta attenuates tumor growth via polarization of tumor associated neutrophils towards an anti-tumor phenotype in colorectal cancer J Cancer, 2020-02-14;11(9):2580-2592. 2020-02-14 [PMID: 32201528] (Neutralization, Human) |
Neutralization |
Human |
A van Caam, J Aarts, T van Ee, E Vitters, M Koenders, F van de Loo, P van Lent, F van den Ho, R Thurlings, MC Vonk, PM van der Kr TGF&beta-mediated expression of TGF&beta-activating integrins in SSc monocytes: disturbed activation of latent TGF&beta? Arthritis Res. Ther., 2020-03-06;22(1):42. 2020-03-06 [PMID: 32143707] (Neutralization, Human) |
Neutralization |
Human |
Kai Zhang, Chun Yang, Lijia Chang, Akemi Sakamoto, Toru Suzuki, Yuko Fujita et al. Essential role of microglial transforming growth factor-beta 1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-beta 1 Translational Psychiatry 1/27/2020 [PMID: 32066676] |
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Richardson LS, Taylor RN, Menon R. Reversible EMT and MET mediate amnion remodeling during pregnancy and labor Science Signaling 2020-02-13 [PMID: 32047115] |
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S Li, Y Fan, A Kumagai, E Kawakita, M Kitada, K Kanasaki, D Koya Deficiency in Dipeptidyl Peptidase-4 Promotes Chemoresistance through the CXCL12/CXCR4/mTOR/TGF&beta Signaling Pathway in Breast Cancer Cells Int J Mol Sci, 2020-01-26;21(3):. 2020-01-26 [PMID: 31991851] (Neutralization, Mouse) |
Neutralization |
Mouse |
Y Takagaki, SM Lee, Z Dongqing, M Kitada, K Kanasaki, D Koya Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis Autophagy, 2020-01-22;0(0):1-10. 2020-01-22 [PMID: 31965901] (Neutralization, Human) |
Neutralization |
Human |
Meaghan H. Hancock, Lindsey B. Crawford, Andrew H. Pham, Jennifer Mitchell, Hillary M. Struthers, Andrew D. Yurochko et al. Human Cytomegalovirus miRNAs Regulate TGF-beta to Mediate Myelosuppression while Maintaining Viral Latency in CD34+ Hematopoietic Progenitor Cells Cell Host & Microbe 2020-01-01 [PMID: 31866424] |
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C Hiepen, J Jatzlau, S Hildebrand, B Kampfrath, M Goktas, A Murgai, JL Cuellar Ca, R Haag, C Ruppert, G Sengle, EA Cavalcanti, KG Blank, P Knaus BMPR2 acts as a�gatekeeper to protect endothelial cells from increased TGF&beta�responses and altered cell mechanics PLoS Biol., 2019-12-11;17(12):e3000557. 2019-12-11 [PMID: 31826007] (Western Blot, Human) |
Western Blot |
Human |
Erine H. Budi, Steven Hoffman, Shaojian Gao, Ying E. Zhang, Rik Derynck Integration of TGF-beta -induced Smad signaling in the insulin-induced transcriptional response in endothelial cells Scientific Reports 11/18/2019 [PMID: 31740700] |
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Fabian Emrich, Kiril Penov, Mamoru Arakawa, Nathan Dhablania, Grayson Burdon, Albert J. Pedroza et al. Anatomically specific reactive oxygen species production participates in Marfan syndrome aneurysm formation Journal of Cellular and Molecular Medicine 2019-10-01 [PMID: 31402541] |
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MR Shokri, M Bozorgmehr, A Ghanavatin, R Falak, M Aleahmad, S Kazemnejad, F Shokri, AH Zarnani Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells Sci Rep, 2019-07-10;9(1):10007. 2019-07-10 [PMID: 31292483] (Bioassay, Human) |
Bioassay |
Human |
Wenshan Wang, Jeff Ishibashi, Sophie Trefely, Mengle Shao, Alexis J. Cowan, Alexander Sakers et al. A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate Cell Metabolism 2019-07-01 [PMID: 31155495] |
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Matteo Ligorio, Srinjoy Sil, Jose Malagon-Lopez, Linda T. Nieman, Sandra Misale, Mauro Di Pilato et al. Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer Cell 2019-06-01 [PMID: 31155233] |
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H Yu, S Ma, L Sun, J Gao, C Zhao TGF??1 upregulates the expression of lncRNA?ATB to promote atherosclerosis Mol Med Rep, 2019-03-29;19(5):4222-4228. 2019-03-29 [PMID: 30942415] (ELISA Development (Capture), Human) |
ELISA Development (Capture) |
Human |
Gaoyuan Wang, Junqiang Zhang, Yuan Fang, Wei Cao, Bin Xu, Xiaoyu Chen Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25‑dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation Experimental and Therapeutic Medicine 11/30/2018 [PMID: 30651850] |
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B Wang, S Wu, Z Ma, T Wang, C Yang BMSCs pre-treatment ameliorates inflammation-related tissue destruction in LPS-induced rat DIC model Cell Death Dis, 2018-10-03;9(10):1024. 2018-10-03 [PMID: 30282969] (Neutralization, Rat) |
Neutralization |
Rat |
T Shindo, S Doi, A Nakashima, K Sasaki, K Arihiro, T Masaki TGF-?1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA Sci Rep, 2018-09-19;8(1):14060. 2018-09-19 [PMID: 30232404] (Neutralization, Mouse) |
Neutralization |
Mouse |
M Idelson, R Alper, A Obolensky, N Yachimovic, J Rachmilewi, A Ejzenberg, E Beider, E Banin, B Reubinoff Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Stem Cell Reports, 2018-08-16;0(0):. 2018-08-16 [PMID: 30122442] (Neutralization, Human) |
Neutralization |
Human |
Bing Liu, Lili Xu, Xinming Yu, Wei Li, Xiaozhi Sun, Shun Xiao, Mingjin Guo, Haofu Wang Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF??. Molecular Medicine Reports, 2018-06-20;0(0):1791-3004. 2018-06-20 [PMID: 29956764] (Western Blot, Human) |
Western Blot |
Human |
X Wang, F Dong, S Zhang, W Yang, W Yu, Z Wang, S Zhang, J Wang, S Ma, P Wu, Y Gao, J Dong, F Tang, T Cheng, H Ema TGF-?1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells Stem Cell Reports, 2018-06-21;0(0):. 2018-06-21 [PMID: 29937145] (Neutralization, Mouse) |
Neutralization |
Mouse |
S Tiwary, JE Morales, SC Kwiatkowsk, FF Lang, G Rao, JH McCarty Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a Sci Rep, 2018-05-29;8(1):8267. 2018-05-29 [PMID: 29844613] (Neutralization, Human) |
Neutralization |
Human |
L Huang, J Deng, W Xu, H Wang, L Shi, F Wu, D Wu, W Nei, M Zhao, P Mao, X Zhou CD8+ T cells with high TGF??1 expression cause lymph node fibrosis following HIV infection Mol Med Rep, 2018-05-03;0(0):. 2018-05-03 [PMID: 29749506] (Agonist Activity, Human) |
Agonist Activity |
Human |
CKS Wong, A Falkenham, T Myers, JF Légaré Connective tissue growth factor expression after angiotensin II exposure is dependent on transforming growth factor-? signaling via the canonical Smad-dependent pathway in hypertensive induced myocardial fibrosis J Renin Angiotensin Aldosterone Syst, 2018-01-01;19(1):1470320318759. 2018-01-01 [PMID: 29575960] (Neutralization, Mouse) |
Neutralization |
Mouse |
SS Said, GT Barut, N Mansur, A Korkmaz, A Sayi-Yazga Bacterially activated B-cells drive T cell differentiation towards Tr1 through PD-1/PD-L1 expression Mol. Immunol., 2018-02-26;96(0):48-60. 2018-02-26 [PMID: 29494848] (Neutralization, Mouse) |
Neutralization |
Mouse |
JR Cortes, A Ambesi-Imp, L Couronné, SA Quinn, CS Kim, AC da Silva A, Z West, L Belver, MS Martin, L Scourzic, G Bhagat, OA Bernard, AA Ferrando, T Palomero RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis Cancer Cell, 2018-02-02;33(2):259-273.e7. 2018-02-02 [PMID: 29398449] (Activation, Mouse) |
Activation |
Mouse |
M Yuan, PJ Pai, X Liu, H Lam, BP Chan Proteomic Analysis of Nucleus Pulposus Cell-derived Extracellular Matrix Niche and Its Effect on Phenotypic Alteration of Dermal Fibroblasts Sci Rep, 2018-01-24;8(1):1512. 2018-01-24 [PMID: 29367647] (ICC, Rabbit) |
ICC |
Rabbit |
N Caronni, F Simoncello, F Stafetta, C Guarnaccia, JS Ruiz-Moren, B Opitz, T Galli, V Proux-Gill, F Benvenuti Downregulation of membrane trafficking proteins and lactate conditioning determine loss of dendritic cell function in lung cancer Cancer Res., 2018-01-23;0(0):. 2018-01-23 [PMID: 29363545] (Bioassay, Mouse) |
Bioassay |
Mouse |
P Linares-Cl, D Aguilar-Mo, I Rodríguez-, G Ramírez, C de Torres, V Santamaría, D Pascual-Va, A Colmenero-, FM Vega, J Mora, R Cabello, C Márquez, E Rivas, R Pardal Neural crest derived progenitor cells contribute to tumor stroma and aggressiveness in stage 4/M neuroblastoma Oncotarget, 2017-09-21;8(52):89775-89792. 9/21/2017 [PMID: 29163787] |
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Veronika Maria Metzler, Christian Pritz, Anna Riml, Angela Romani, Raphaela Tuertscher, Teresa Steinbichler et al. Separation of cell survival, growth, migration, and mesenchymal transdifferentiation effects of fibroblast secretome on tumor cells of head and neck squamous cell carcinoma Tumour Biol. 2018-07-03 [PMID: 29157176] |
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Nancy Adriana Espinoza-Sánchez, Eduardo Vadillo, Juan Carlos Balandrán, Alberto Monroy-García, Rosana Pelayo, Ezequiel M. Fuentes-Pananá Evidence of lateral transmission of aggressive features between different types of breast cancer cells International Journal of Oncology 2017-11-01 [PMID: 29048610] |
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G Holdsworth, H Bon, M Bergin, O Qureshi, R Paveley, J Atkinson, L Huang, R Tewari, B Twomey, T Johnson Quantitative and organisational changes in mature extracellular matrix revealed through high-content imaging of total protein fluorescently stained in situ Sci Rep, 2017-08-30;7(1):9963. 8/30/2017 [PMID: 28855577] |
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M Pasztoi, J Pezoldt, M Beckstette, C Lipps, D Wirth, M Rohde, K Paloczi, EI Buzas, J Huehn Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3(+) regulatory T cells Eur. J. Immunol., 2017-09-15;0(0):. 2017-09-15 [PMID: 28833065] (Neutralization, Mouse) |
Neutralization |
Mouse |
Allah Nawaz, Aminuddin Aminuddin, Tomonobu Kado, Akiko Takikawa, Seiji Yamamoto, Koichi Tsuneyama et al. CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors Nature Communications 2017-08-18 [PMID: 28819169] |
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RM Petri, A Hackel, K Hahnel, CA Dumitru, K Bruderek, SB Flohe, A Paschen, S Lang, S Brandau Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function Stem Cell Reports, 2017-08-03;0(0):. 2017-08-03 [PMID: 28781075] (Neutralization, Human) |
Neutralization |
Human |
Li J, Shi S, et al. FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway. Cell Death Dis 8/3/2017 [PMID: 28771231] |
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Saleh Rachidi, Alessandra Metelli, Brian Riesenberg, Bill X. Wu, Michelle H. Nelson, Caroline W Wallace et al. Platelets subvert T cell immunity against cancer via GARP-TGF beta axis Science Immunology 2017-05-05 [PMID: 28763790] |
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Ashlee J. Tipton, Jacqueline B. Musall, G. Ryan Crislip, Jennifer C. Sullivan Greater transforming growth factor-beta in adult female SHR is dependent on blood pressure, but does not account for sex differences in renal T-regulatory cells American Journal of Physiology-Renal Physiology 2017-10-01 [PMID: 28679591] |
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S Khakipoor, C Ophoven, M Schrödl-Hä, M Feuerstein, B Heimrich, JW Deitmer, E Roussa TGF-? signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes Glia, 2017-06-01;0(0):. 2017-06-01 [PMID: 28568893] (Neutralization, Mouse) |
Neutralization |
Mouse |
CJ Bohlen, FC Bennett, AF Tucker, HY Collins, SB Mulinyawe, BA Barres Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures Neuron, 2017-05-17;94(4):759-773.e8. 2017-05-17 [PMID: 28521131] (Neutralization, Rat) |
Neutralization |
Rat |
D Gonzalez, O Contreras, DL Rebolledo, JP Espinoza, B van Zunder, E Brandan ALS skeletal muscle shows enhanced TGF-? signaling, fibrosis and induction of fibro/adipogenic progenitor markers PLoS ONE, 2017-05-16;12(5):e0177649. 2017-05-16 [PMID: 28520806] (Western Blot, Mouse) |
Western Blot |
Mouse |
N Köstlin, M Vogelmann, B Spring, J Schwarz, J Feucht, C Härtel, TW Orlikowsky, CF Poets, C Gille Granulocytic myeloid derived suppressor cells from human cord blood modulate T-helper-cell response towards an anti-inflammatory phenotype Immunology, 2017-06-08;0(0):. 2017-06-08 [PMID: 28464218] (Neutralization, Human) |
Neutralization |
Human |
L Ritsma, I Dey-Guha, N Talele, X Sole, Salony, J Chowdhury, KN Ross, S Ramaswamy Integrin ?1 activation induces an anti-melanoma host response PLoS ONE, 2017-04-27;12(4):e0175300. 2017-04-27 [PMID: 28448494] (Functional Assay, Human) |
Functional Assay |
Human |
Q Bian, L Ma, A Jain, JL Crane, K Kebaish, M Wan, Z Zhang, X Edward Guo, PD Sponseller, CA Séguin, LH Riley, Y Wang, X Cao Mechanosignaling activation of TGF? maintains intervertebral disc homeostasis Bone Res, 2017-03-21;5(0):17008. 2017-03-21 [PMID: 28392965] (Bioassay, Neutralization, Mouse, Rat) |
Bioassay, Neutralization |
Mouse, Rat |
K Brekke, M Sommerfelt, M Ökvist, AM Dyrhol-Rii, D Kvale The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study BMC Infect. Dis, 2017-03-24;17(1):228. 2017-03-24 [PMID: 28340570] (Neutralization, Human) |
Neutralization |
Human |
DJ Urban, N Anthwal, ZX Luo, JA Maier, A Sadier, AS Tucker, KE Sears A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw Proc. Biol. Sci, 2017-02-08;284(1848):. 2017-02-08 [PMID: 28179517] (In Vivo, Opossum) |
In Vivo |
Opossum |
HR Gatla, Y Zou, MM Uddin, B Singha, P Bu, A Vancura, I Vancurova Histone Deacetylase (HDAC) Inhibition Induces I?B Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells J. Biol. Chem., 2017-02-06;292(12):5043-5054. 2017-02-06 [PMID: 28167529] (Western Blot, Human) |
Western Blot |
Human |
Massimiliano Mellone, Christopher J. Hanley, Steve Thirdborough, Toby Mellows, Edwin Garcia, Jeongmin Woo et al. Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis Aging (Albany NY) 2016-12-15 [PMID: 27992856] |
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Kluyveromyces marxianus and Saccharomyces boulardii Induce Distinct Levels of Dendritic Cell Cytokine Secretion and Significantly Different T Cell Responses In Vitro PLoS ONE, 2016-11-29;11(11):e0167410. 2016-11-29 [PMID: 27898740] (Neutralization, Human) |
Neutralization |
Human |
Adam D. Coster, Curtis A. Thorne, Lani F. Wu, Steven J. Altschuler Examining Crosstalk among Transforming Growth Factor beta , Bone Morphogenetic Protein, and Wnt Pathways* Journal of Biological Chemistry 2017-01-06 [PMID: 27895117] |
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Jeremy S Duffield Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury J. Clin. Invest., 2016-11-21;0(0):. 2016-11-21 [PMID: 27869651] (Neutralization, Mouse) |
Neutralization |
Mouse |
Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion PLoS ONE, 2016-11-16;11(11):e0166500. 2016-11-16 [PMID: 27851822] (Neutralization, Human) |
Neutralization |
Human |
Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs Nature, 2016-11-09;0(0):. 2016-11-09 [PMID: 27828940] (Bioassay, Mouse) |
Bioassay |
Mouse |
S S Prime Cancer associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-�-dependent pathways in genotype-specific oral cancer Carcinogenesis, 2016-11-01;0(0):. 2016-11-01 [PMID: 27803052] (Neutralization, Human) |
Neutralization |
Human |
Sterile Inflammation Enhances ECM Degradation in Integrin ?1 KO Embryonic Skin Cell Rep, 2016-09-20;16(12):3334-47. 2016-09-20 [PMID: 27653694] (IHC, Mouse) |
IHC |
Mouse |
TGF-?1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT) PLoS ONE, 2016-09-02;11(9):e0162221. 2016-09-02 [PMID: 27589056] (Neutralization, Human) |
Neutralization |
Human |
Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes Stem Cell Reports, 2016-08-25;0(0):. 2016-08-25 [PMID: 27569062] (Neutralization, Human) |
Neutralization |
Human |
Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy Arthritis Res Ther, 2016-08-11;18(1):184. 2016-08-11 [PMID: 27516061] (In Vivo, Mouse) |
In Vivo |
Mouse |
Fangfang Duan, Dongwei Jia, Junjie Zhao, Weicheng Wu, Lingqiang Min, Shushu Song et al. Loss of GFAT1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer Oncotarget 2016-06-21 [PMID: 27509259] |
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K+/Cl- cotransporter KCC2 membrane trafficking and functionality is regulated by transforming growth factor beta 2 J Cell Sci, 2016-08-05;0(0):. 2016-08-05 [PMID: 27505893] (Bioassay, Mouse) |
Bioassay |
Mouse |
I Minn, SM Koo, HS Lee, M Brummet, SP Rowe, MA Gorin, P Sysa-Shah, WD Lewis, HH Ahn, Y Wang, SR Banerjee, RC Mease, S Nimmagadda, ME Allaf, MG Pomper, X Yang [64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma Oncotarget, 2016-08-30;7(35):56471-56479. 2016-08-30 [PMID: 27437764] (Neutralization, Mink) |
Neutralization |
Mink |
Fatemeh Mirzamoham Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-? signalling Nat Commun, 2016-06-22;7(0):12047. 2016-06-22 [PMID: 27329220] (Neutralization, Mouse) |
Neutralization |
Mouse |
X Chen, DL Rateri, DA Howatt, A Balakrishn, JJ Moorleghen, LA Cassis, A Daugherty TGF-? Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions PLoS ONE, 2016-04-22;11(4):e0153811. 2016-04-22 [PMID: 27104863] (Neutralization, Mouse) |
Neutralization |
Mouse |
H Nagashima, Y Okuyama, T Hayashi, N Ishii, T So TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development J Immunol, 2016-04-13;0(0):. 2016-04-13 [PMID: 27076680] |
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Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta. Immunol Cell Biol, 2016-05-10;94(8):747-62. 2016-05-10 [PMID: 27075967] (Neutralization, Human) |
Neutralization |
Human |
Holly E. M. Mewhort, Brodie D. Lipon, Daniyil A. Svystonyuk, Guoqi Teng, David G. Guzzardi, Claudia Silva et al. Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-beta 1 American Journal of Physiology-Heart and Circulatory Physiology 2016-03-15 [PMID: 26801303] |
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Ting Liu, Jun Ren, Wei Wang, Xia-wei Wei, Guo-bo Shen, Yan-tong Liu et al. Treatment of dextran sodium sulfate-induced experimental colitis by adoptive transfer of peritoneal cells Scientific Reports 2015-11-13 [PMID: 26565726] |
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Daniel Bedinger, Llewelyn Lao, Shireen Khan, Steve Lee, Toshihiko Takeuchi, Amer M. Mirza Development and characterization of human monoclonal antibodies that neutralize multiple TGF beta isoforms mAbs 2016-02-17 [PMID: 26563652] |
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HAIJUN LI, DONGBEI LI, JITONG SUN, YINAN LI, WEI YANG, YI LI Autoimmune regulator-overexpressing dendritic cells induce T helper 1 and T helper 17 cells by upregulating cytokine expression Molecular Medicine Reports 2016-01-01 [PMID: 26548750] |
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Hang Yuan, Marpadga A. Reddy, Supriya Deshpande, Ye Jia, Jung Tak Park, Linda L. Lanting et al. Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy Antioxidants & Redox Signaling 2016-03-01 [PMID: 26492974] |
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Ryan J. Coram, Samantha J. Stillwagon, Anuradha Guggilam, Michael W. Jenkins, Maurice S. Swanson, Andrea N. Ladd Muscleblind-like 1 is required for normal heart valve development in vivo BMC Developmental Biology 2015-12-01 [PMID: 26472242] |
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Carthy J, Engstrom U, Heldin C, Moustakas A Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-beta Signaling. J Cell Biochem, 2015-09-22;117(4):938-45. 2015-09-22 [PMID: 26369756] (Bioassay, Mouse) |
Bioassay |
Mouse |
Cho K, Lee J, Park M, Park H, Yu H, Roh H Prostaglandin E2 and Transforming Growth Factor-beta Play a Critical Role in Suppression of Allergic Airway Inflammation by Adipose-Derived Stem Cells. PLoS ONE, 2015-07-15;10(7):e0131813. 7/15/2015 [PMID: 26176545] |
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Kippenberger S, Zoller N, Kleemann J, Muller J, Kaufmann R, Hofmann M, Bernd A, Meissner M, Valesky E STAT6-Dependent Collagen Synthesis in Human Fibroblasts Is Induced by Bovine Milk. PLoS ONE, 2015-07-02;10(7):e0131783. 2015-07-02 [PMID: 26134630] (Neutralization, Bovine) |
Neutralization |
Bovine |
Fornetti J, Flanders K, Henson P, Tan A, Borges V, Schedin P Mammary epithelial cell phagocytosis downstream of TGF-beta3 is characterized by adherens junction reorganization. Cell Death Differ, 2015-06-26;23(2):185-96. 2015-06-26 [PMID: 26113040] (Western Blot, Rat) |
Western Blot |
Rat |
Yongyan Chen, Rui Sun, Xunyao Wu, Min Cheng, Haiming Wei, Zhigang Tian CD4+CD25+ Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis B Virus Transgenic Mice via Membrane-Bound TGF-beta and OX40 Journal of Innate Immunity 2016-01-01 [PMID: 26067079] |
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Dayer C, Stamenkovic I Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-beta (TGF-beta) Activation and Fibroblast Differentiation. J Biol Chem, 2015-03-30;290(22):13763-78. 2015-03-30 [PMID: 25825495] (Neutralization, Human) |
Neutralization |
Human |
Pieters B, Arntz O, Bennink M, Broeren M, van Caam A, Koenders M, van Lent P, van den Berg W, de Vries M, van der Kraan P, van de Loo F Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-beta. PLoS ONE, 2015-03-30;10(3):e0121123. 2015-03-30 [PMID: 25822997] (Neutralization, Mouse) |
Neutralization |
Mouse |
Li Y, Song D, Song Y, Zhao L, Wolkow N, Tobias J, Song W, Dunaief J Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-beta Signaling in the Retinal Pigment Epithelium. J Biol Chem, 2015-03-23;290(19):11918-34. 2015-03-23 [PMID: 25802332] (Neutralization, Human) |
Neutralization |
Human |
Rugmani Padmanabhan Iyer, Nicolle L. Patterson, Fouad A. Zouein, Yonggang Ma, Vincent Dive, Lisandra E. de Castro Brás et al. Early matrix metalloproteinase-12 inhibition worsens post-myocardial infarction cardiac dysfunction by delaying inflammation resolution International Journal of Cardiology 2015-04-15 [PMID: 25797678] |
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Dutta A, Huang C, Chen T, Lin C, Chiu C, Lin Y, Chang C, He Y IL-10 inhibits neuraminidase-activated TGF-beta and facilitates Th1 phenotype during early phase of infection. Nat Commun, 2015-03-02;6(0):6374. 2015-03-02 [PMID: 25728041] (Neutralization, Mouse) |
Neutralization |
Mouse |
Ungefroren H, Hyder A, Hinz H, Groth S, Lange H, El-Sayed K, Ehnert S, Nussler A, Fandrich F, Gieseler F Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-beta. PLoS ONE, 2015-02-23;10(2):e0118097. 2015-02-23 [PMID: 25707005] (Neutralization, Human) |
Neutralization |
Human |
Chang T, Poltoratsky V, Vancurova I Bortezomib inhibits expression of TGF-beta1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells. J Immunol, 2015-02-13;194(6):2942-53. 2015-02-13 [PMID: 25681335] (Neutralization, Human) |
Neutralization |
Human |
Rossetti M, Spreafico R, Saidin S, Chua C, Moshref M, Leong J, Tan Y, Thumboo J, van Loosdregt J, Albani S Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region. J Immunol, 2014-12-01;194(1):113-24. 2014-12-01 [PMID: 25452562] (Neutralization, Human) |
Neutralization |
Human |
Mizuuchi Y, Aishima S, Ohuchida K, Shindo K, Fujino M, Hattori M, Miyazaki T, Mizumoto K, Tanaka M, Oda Y Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition. Lab Invest, 2014-11-24;95(2):193-206. 2014-11-24 [PMID: 25418581] (Neutralization, Human) |
Neutralization |
Human |
Schmetterer K, Neunkirchner A, Wojta-Stremayr D, Leitner J, Steinberger P, Pickl W STAT3 governs hyporesponsiveness and granzyme B-dependent suppressive capacity in human CD4+ T cells. FASEB J, 2014-11-14;29(3):759-71. 2014-11-14 [PMID: 25398767] (Blocking, Human) |
Blocking |
Human |
Jolly L, Stavrou A, Vanderstoken G, Meliopoulos V, Habgood A, Tatler A, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli M, Schultz-Cherry S, Jenkins G Influenza promotes collagen deposition via alphavbeta6 integrin-mediated transforming growth factor beta activation. J Biol Chem, 2014-10-22;289(51):35246-63. 2014-10-22 [PMID: 25339175] (Neutralization, Human) |
Neutralization |
Human |
Carrillo-Galvez A, Cobo M, Cuevas-Ocana S, Gutierrez-Guerrero A, Sanchez-Gilabert A, Bongarzone P, Garcia-Perez A, Munoz P, Benabdellah K, Toscano M, Martin F, Anderson P Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity. Stem Cells, 2015-01-01;33(1):183-95. 2015-01-01 [PMID: 25182959] (Neutralization, Mouse) |
Neutralization |
Mouse |
Hassona Y, Cirillo N, Heesom K, Parkinson E, Prime S Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion. Br J Cancer, 2014-08-12;111(6):1230-7. 2014-08-12 [PMID: 25117810] (Neutralization, Human) |
Neutralization |
Human |
Guzman E, Hope J, Taylor G, Smith A, Cubillos-Zapata C, Charleston B Bovine gammadelta T cells are a major regulatory T cell subset. J Immunol, 2014-06-02;193(1):208-22. 2014-06-02 [PMID: 24890724] (Bioassay, Bovine) |
Bioassay |
Bovine |
Alcaraz L, Exposito J, Chuvin N, Pommier R, Cluzel C, Martel S, Sentis S, Bartholin L, Lethias C, Valcourt U Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-beta. J Cell Biol, 2014-05-12;205(3):409-28. 2014-05-12 [PMID: 24821840] (Neutralization, Western Blot, Human, Mouse) |
Neutralization, Western Blot |
Human, Mouse |
Gao P, Zhou Y, Xian L, Li C, Xu T, Plunkett B, Huang S, Wan M, Cao X Functional effects of TGF-beta1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma. J Immunol, 2014-04-07;192(10):4560-70. 2014-04-07 [PMID: 24711618] (Neutralization, Human) |
Neutralization |
Human |
Lin Z, Wang C, Xia H, Liu W, Xiao W, Qian L, Jia X, Ding Y, Ji M, Gong W CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1epsilon transgenic mice. Immunology, 2014-03-01;141(3):401-15. 2014-03-01 [PMID: 24708417] (Neutralization, Mouse) |
Neutralization |
Mouse |
Nagashima , Hiroyuki, Okuyama , Yuko, Asao , Atsuko, Kawabe , Takeshi, Yamaki , Satoshi, Nakano , Hiroyasu, Croft , Michael, Ishii , Naoto, So , Takanori The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Nat Immunol, 2014-03-30;15(5):449-56. 2014-03-30 [PMID: 24681564] (Neutralization, Mouse) |
Neutralization |
Mouse |
Faustino L, Fonseca D, Florsheim E, Resende R, Lepique A, Faquim-Mauro E, Gomes E, Silva J, Yagita H, Russo M Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation. Mucosal Immunol, 2014-02-26;7(5):1199-208. 2014-02-26 [PMID: 24569802] (Neutralization, Mouse) |
Neutralization |
Mouse |
Cook J, Carta L, Benard L, Chemaly E, Chiu E, Rao S, Hampton T, Yurchenco P, Costa K, Hajjar R, Ramirez F Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. J Clin Invest, 2014-02-17;124(3):1329-39. 2014-02-17 [PMID: 24531548] (Neutralization, Mouse) |
Neutralization |
Mouse |
Weaver S, Wolters B, Ito N, Woskowicz A, Kaneko K, Shitomi Y, Seiki M, Itoh Y Basal localization of MT1-MMP is essential for epithelial cell morphogenesis in 3D collagen matrix. J Cell Sci, 2014-01-24;127(0):1203-13. 2014-01-24 [PMID: 24463815] (Neutralization, Canine, Human, Mouse) |
Neutralization |
Canine, Human, Mouse |
Craft C, Pietka T, Schappe T, Coleman T, Combs M, Klein S, Abumrad N, Mecham R The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-beta. Diabetes, 2014-01-23;63(6):1920-32. 2014-01-23 [PMID: 24458361] (Neutralization, Mouse) |
Neutralization |
Mouse |
Chakrabarti L, Wang B, Lee N, Sandler A A mechanism linking Id2-TGFbeta crosstalk to reversible adaptive plasticity in neuroblastoma. PLoS ONE, 2013-12-23;8(12):e83521. 2013-12-23 [PMID: 24376712] (Neutralization, Western Blot, Mouse) |
Neutralization, Western Blot |
Mouse |
Wu Z, Horgan C, Carr O, Owens R, Iozzo R, Lechner B Biglycan and decorin differentially regulate signaling in the fetal membranes. Matrix Biol, 2013-12-25;35(0):266-75. 2013-12-25 [PMID: 24373743] (Western Blot, Mouse) |
Western Blot |
Mouse |
Zhou A, El Hed A, Mercer F, Kozhaya L, Unutmaz D The metalloprotease ADAM12 regulates the effector function of human Th17 cells. PLoS ONE, 2013-11-21;8(11):e81146. 2013-11-21 [PMID: 24363794] (Neutralization, Human) |
Neutralization |
Human |
Gallo E, Loch D, Habashi J, Calderon J, Chen Y, Bedja D, van Erp C, Gerber E, Parker S, Sauls K, Judge D, Cooke S, Lindsay M, Rouf R, Myers L, ap Rhys C, Kent K, Norris R, Huso D, Dietz H Angiotensin II-dependent TGF-beta signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. J Clin Invest, 2013-12-20;124(1):448-60. 2013-12-20 [PMID: 24355923] (Neutralization, Mouse) |
Neutralization |
Mouse |
Musso A, Catellani S, Canevali P, Tavella S, Vene R, Boero S, Pierri I, Gobbi M, Kunkl A, Ravetti J, Zocchi M, Poggi A Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vdelta 2 T lymphocytes in non-Hodgkin lymphomas. Haematologica, 2013-10-25;99(1):131-9. 2013-10-25 [PMID: 24162786] (Neutralization, Human) |
Neutralization |
Human |
Bialas A, Stevens B TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci, 2013-10-27;16(12):1773-82. 2013-10-27 [PMID: 24162655] (Immunodepletion, Mouse) |
Immunodepletion |
Mouse |
Kameswara Rao Badri, Ming Yue, Oscar A. Carretero, Sree Latha Aramgam, Jun Cao, Stephen Sharkady et al. Blood pressure homeostasis is maintained by a P311–TGF-beta axis Journal of Clinical Investigation 2013-10-01 [PMID: 24091331] |
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Gandhi N, Su Z, Zhang X, Volpe E, Pelegrino F, Rahman S, Li D, Pflugfelder S, de Paiva C Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. J Leukoc Biol, 2013-08-27;94(6):1293-301. 2013-08-27 [PMID: 23983225] (Neutralization, Mouse) |
Neutralization |
Mouse |
Marloes L. de Vries–van Melle, Roberto Narcisi, Nicole Kops, Wendy J.L.M. Koevoet, P. Koen Bos, J. Mary Murphy et al. Chondrogenesis of Mesenchymal Stem Cells in an Osteochondral Environment Is Mediated by the Subchondral Bone Tissue Engineering Part A 2014-01-01 [PMID: 23980750] |
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Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, Konkel J, Maruyama T, Wei G, Abbatiello B, Wang Z, Zhao K, Chen W PARP-1 regulates expression of TGF-beta receptors in T cells. Blood, 2013-08-12;122(13):2224-32. 2013-08-12 [PMID: 23940283] (Flow Cytometry, Mouse) |
Flow Cytometry |
Mouse |
Mitsuo Kato, Varun Dang, Mei Wang, Jung Tak Park, Supriya Deshpande, Swati Kadam et al. TGF-beta Induces Acetylation of Chromatin and of Ets-1 to Alleviate Repression of miR-192 in Diabetic Nephropathy Science Signaling 2013-06-04 [PMID: 23737551] |
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|
Yu C, Becker C, Wang Y, Marches F, Helft J, Leboeuf M, Anguiano E, Pourpe S, Goller K, Pascual V, Banchereau J, Merad M, Palucka K Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-beta. Immunity, 2013-04-04;38(4):818-30. 2013-04-04 [PMID: 23562160] (Neutralization, Human) |
Neutralization |
Human |
Nakagawa R, Togawa A, Nagasawa T, Nishikawa S Peyer's patch inducer cells play a leading role in the formation of B and T cell zone architecture. J Immunol, 2013-03-04;190(7):3309-18. 2013-03-04 [PMID: 23460741] (Neutralization, Mouse) |
Neutralization |
Mouse |
Schreiner J, Kretschmer D, Klenk J, Otto M, Buhring H, Stevanovic S, Wang J, Beer-Hammer S, Peschel A, Autenrieth S Staphylococcus aureus phenol-soluble modulin peptides modulate dendritic cell functions and increase in vitro priming of regulatory T cells. J Immunol, 2013-03-04;190(7):3417-26. 2013-03-04 [PMID: 23460735] (Neutralization, Human) |
Neutralization |
Human |
Norris B, Uebelhoer L, Nakaya H, Price A, Grakoui A, Pulendran B Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity. Immunity, 2013-02-21;38(2):309-21. 2013-02-21 [PMID: 23438822] (Neutralization, Mouse) |
Neutralization |
Mouse |
Guo Z, Khattar M, Schroder P, Miyahara Y, Wang G, He X, Chen W, Stepkowski S A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. J Immunol, 2013-02-20;190(7):3153-62. 2013-02-20 [PMID: 23427250] (Neutralization, Mouse) |
Neutralization |
Mouse |
Kashiwakura Y, Sakurai D, Kanno Y, Hashiguchi M, Kobayashi A, Kurosu A, Tokudome S, Kobata T, Kojima H CD2-mediated regulation of peripheral CD4(+) CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim. Immunology, 2013-05-01;139(1):48-60. 2013-05-01 [PMID: 23278598] (Neutralization, Mouse) |
Neutralization |
Mouse |
Nicole Bedke, David Sammut, Ben Green, Valia Kehagia, Patrick Dennison, Gisli Jenkins et al. Transforming Growth Factor-Beta Promotes Rhinovirus Replication in Bronchial Epithelial Cells by Suppressing the Innate Immune Response PLoS ONE 2012-09-06 [PMID: 22970254] |
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Kathryn E LeMasters, Yotam Blech-Hermoni, Samantha J Stillwagon, Natalie A Vajda, Andrea N Ladd Loss of muscleblind-like 1 promotes invasive mesenchyme formation in endocardial cushions by stimulating autocrine TGF beta 3 BMC Developmental Biology 2012-12-01 [PMID: 22866814] |
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Zhang N, Bevan MJ TGF-beta signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation. Nat. Immunol., 2012-05-27;13(7):667-73. 2012-05-27 [PMID: 22634866] (Neutralization, Mouse) |
Neutralization |
Mouse |
Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Nature, 2012-04-26;484(7395):514-8. 2012-04-26 [PMID: 22466287] (Neutralization, Human) |
Neutralization |
Human |
Zhiping Wu, Abraham W. Aron, Elyse E. Macksoud, Renato V. Iozzo, Chi-Ming Hai, Beatrice E. Lechner Uterine Dysfunction in Biglycan and Decorin Deficient Mice Leads to Dystocia during Parturition PLoS ONE 2012-01-13 [PMID: 22253749] |
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Ma W, Han W, Greer PA, Tuder RM, Toque HA, Wang KK, Caldwell RW, Su Y Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. J. Clin. Invest., 2011-10-17;121(11):4548-66. 2011-10-17 [PMID: 22005303] (ICC, IHC-Fr, Human) |
ICC, IHC-Fr |
Human |
Moses K. Donkor, Abira Sarkar, Peter A. Savage, Ruth A. Franklin, Linda K. Johnson, Achim A. Jungbluth et al. T Cell Surveillance of Oncogene-Induced Prostate Cancer Is Impeded by T Cell-Derived TGF-beta 1 Cytokine Immunity 2011-07-22 [PMID: 21757379] |
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Montane J, Bischoff L, Soukhatcheva G, Dai DL, Hardenberg G, Levings MK, Orban PC, Kieffer TJ, Tan R, Verchere CB Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets. J. Clin. Invest., 2011-08-01;121(0):3024. 2011-08-01 [PMID: 21737880] (Flow Cytometry, Mouse) |
Flow Cytometry |
Mouse |
Rania Esteitie, Janaki Emani, Shilpy Sharma, Dana L. Suskind, Fuad M. Baroody Effect of Fluticasone Furoate on Interleukin 6 Secretion From Adenoid Tissues in Children With Obstructive Sleep Apnea Archives of Otolaryngology–Head & Neck Surgery 2011-06-22 [PMID: 21690510] |
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Chaturvedi V, Collison LW, Guy CS, Workman CJ, Vignali DA Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J. Immunol., 2011-05-16;186(12):6661-6. 2011-05-16 [PMID: 21576509] (Neutralization, Human) |
Neutralization |
Human |
Ilona Gutcher, Moses K. Donkor, Qian Ma, Alexander Y. Rudensky, Richard A. Flavell, Ming O. Li Autocrine Transforming Growth Factor-beta 1 Promotes In Vivo Th17 Cell Differentiation Immunity 2011-03-25 [PMID: 21435587] |
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Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol. Biol. Cell, 2011-03-16;22(10):1686-98. 2011-03-16 [PMID: 21411626] (Neutralization, Canine) |
Neutralization |
Canine |
Dogar AM, Towbin H, Hall J Suppression of latent transforming growth factor (TGF)-beta1 restores growth inhibitory TGF-beta signaling through microRNAs. J. Biol. Chem., 2011-03-14;286(18):16447-58. 3/14/2011 [PMID: 21402698] |
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Silvia Smaldone, Jacopo Olivieri, Gabriele Luca Gusella, Gianluca Moroncini, Armando Gabrielli, Francesco Ramirez Ha-Ras stabilization mediates pro-fibrotic signals in dermal fibroblasts Fibrogenesis & Tissue Repair 2011-12-01 [PMID: 21362163] |
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Guangdong Sun, Marpadga A. Reddy, Hang Yuan, Linda Lanting, Mitsuo Kato, Rama Natarajan Epigenetic Histone Methylation Modulates Fibrotic Gene Expression Journal of the American Society of Nephrology 2010-12-01 [PMID: 20930066] |
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Srivastava K, Zhang T, Yang N, Sampson H, Li XM Anti-Asthma Simplified Herbal Medicine Intervention-induced long-lasting tolerance to allergen exposure in an asthma model is interferon-gamma, but not transforming growth factor-beta dependent. Clin. Exp. Allergy, 2010-11-01;40(11):1678-88. 2010-11-01 [PMID: 20573156] (Neutralization, Mouse) |
Neutralization |
Mouse |
Lu H, Wagner WM, Gad E, Yang Y, Duan H, Amon LM, Van Denend N, Larson ER, Chang A, Tufvesson H, Disis ML Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade. J. Immunol., 2010-03-22;184(9):5360-7. 2010-03-22 [PMID: 20308630] (Neutralization, Mouse) |
Neutralization |
Mouse |
Nor E. Sounni, Kerstin Dehne, Leon van Kempen, Mikala Egeblad, Nesrine I. Affara, Ileana Cuevas et al. Stromal regulation of vessel stability by MMP14 and TGFbeta Disease Models & Mechanisms 2010-04-28 [PMID: 20223936] |
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Tso GH, Law HK, Tu W Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells. Stem Cells, 2010-05-01;28(5):939-54. 2010-05-01 [PMID: 20222014] (Neutralization, Human) |
Neutralization |
Human |
Koo JW, Russo SJ, Ferguson D, Nestler EJ, Duman RS Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc. Natl. Acad. Sci. U.S.A., 2010-01-26;107(6):2669-74. 2010-01-26 [PMID: 20133768] (Neutralization, Mouse) |
Neutralization |
Mouse |
Rahul Kushwah, Jing Wu, Jordan R. Oliver, George Jiang, Jinyi Zhang, Katherine A. Siminovitch et al. Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ Treg European Journal of Immunology 2010-04-01 [PMID: 20101618] |
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Linke A, Goren I, Bosl MR, Pfeilschifter J, Frank S Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1. J. Invest. Dermatol., 2009-11-19;130(3):866-75. 2009-11-19 [PMID: 19924141] (Bioassay, Neutralization, Mouse) |
Bioassay, Neutralization |
Mouse |
Prignano F, Campolmi P, Bonan P Fractional CO2 laser: a novel therapeutic device upon photobiomodulation of tissue remodeling and cytokine pathway of tissue repair. Dermatol Ther, 2009-11-01;22(0):S8-15. 2009-11-01 [PMID: 19891690] (IHC, Human) |
IHC |
Human |
Natalie A. Vajda, Kyle R. Brimacombe, Kathryn E. LeMasters, Andrea N. Ladd Muscleblind-like 1 is a negative regulator of TGF-β-dependent epithelialâmesenchymal transition of atrioventricular canal endocardial cells Developmental Dynamics 2010-03-15 [PMID: 19890912] |
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Han G, Wang R, Chen G Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta. Immunology, 2009-08-04;129(2):197-206. 2009-08-04 [PMID: 19824917] (Neutralization, Mouse) |
Neutralization |
Mouse |
Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat. Immunol., 2009-08-09;10(9):981-91. 2009-08-09 [PMID: 19668220] (Neutralization, Mouse) |
Neutralization |
Mouse |
Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature, 2009-07-05;460(7253):405-9. 2009-07-05 [PMID: 19578362] (Neutralization, Mouse) |
Neutralization |
Mouse |
Vitsky A, Waire J, Pawliuk R, Bond A, Matthews D, Lacasse E, Hawes ML, Nelson C, Richards S, Piepenhagen PA, Garman RD, Andrews L, Thurberg BL, Lonning S, Ledbetter S, Ruzek MC Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues. Am. J. Pathol., 2009-04-30;174(6):2137-49. 2009-04-30 [PMID: 19406991] (Neutralization) |
Neutralization |
|
Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur. J. Immunol., 2009-05-01;39(5):1221-30. 2009-05-01 [PMID: 19350551] (Neutralization, Human) |
Neutralization |
Human |
Nicola T, Hagood JS, James ML, Macewen MW, Williams TA, Hewitt MM, Schwiebert L, Bulger A, Oparil S, Chen YF, Ambalavanan N Loss of Thy-1 inhibits alveolar development in the newborn mouse lung. Am. J. Physiol. Lung Cell Mol. Physiol., 2009-03-06;296(5):L738-50. 2009-03-06 [PMID: 19270178] (Neutralization, Mouse) |
Neutralization |
Mouse |
Tran DQ, Glass DD, Uzel G, Darnell DA, Spalding C, Holland SM, Shevach EM Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function. J. Immunol., 2009-03-01;182(5):2929-38. 2009-03-01 [PMID: 19234188] (Neutralization, Mouse) |
Neutralization |
Mouse |
Han Y, Guo Q, Zhang M, Chen Z, Cao X CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1. J. Immunol., 2009-01-01;182(1):111-20. 2009-01-01 [PMID: 19109141] (Neutralization, Mouse) |
Neutralization |
Mouse |
Pen A, Moreno MJ, Durocher Y, Deb-Rinker P, Stanimirovic DB Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling. Oncogene, 2008-08-18;27(54):6834-44. 2008-08-18 [PMID: 18711401] (Neutralization, Human) |
Neutralization |
Human |
Akool el-S, Doller A, Babelova A, Tsalastra W, Moreth K, Schaefer L, Pfeilschifter J, Eberhardt W Molecular mechanisms of TGFbeta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. J. Immunol., 2008-08-15;181(4):2831-45. 2008-08-15 [PMID: 18684975] (Neutralization, Rat) |
Neutralization |
Rat |
Carlson ME, Hsu M, Conboy IM Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells. Nature, 2008-06-15;454(7203):528-32. 2008-06-15 [PMID: 18552838] (Neutralization, Mouse) |
Neutralization |
Mouse |
van der Vliet HJ, Wang R, Yue SC, Koon HB, Balk SP, Exley MA Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. J. Immunol., 2008-06-01;180(11):7287-93. 2008-06-01 [PMID: 18490728] (Neutralization, Human) |
Neutralization |
Human |
Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, Chen W CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells. Nat. Med., 2008-04-27;14(5):528-35. 2008-04-27 [PMID: 18438416] (Neutralization, Mouse) |
Neutralization |
Mouse |
Haanstra KG, van der Maas MJ, 't Hart BA, Jonker M Characterization of naturally occurring CD4+CD25+ regulatory T cells in rhesus monkeys. Transplantation, 2008-04-27;85(8):1185-92. 2008-04-27 [PMID: 18431240] (Neutralization, Primate - Macaca mulatta (Rhesus Macaque)) |
Neutralization |
Primate - Macaca mulatta (Rhesus Macaque) |
Terme M, Chaput N, Combadiere B, Ma A, Ohteki T, Zitvogel L Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J. Immunol., 2008-04-01;180(7):4679-86. 2008-04-01 [PMID: 18354191] (Neutralization, Mouse) |
Neutralization |
Mouse |
Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production. Am. J. Pathol., 2008-03-18;172(4):1127-40. 2008-03-18 [PMID: 18349127] (Flow Cytometry, Neutralization, Human, Mink) |
Flow Cytometry, Neutralization |
Human, Mink |
Olav A. Gressner, Birgit Lahme, Monika Siluschek, Katharina Rehbein, Jens Herrmann, Ralf Weiskirchen et al. Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor Journal of Cellular and Molecular Medicine 2008-12-02 [PMID: 18266973] |
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He R, Oyoshi MK, Jin H, Geha RS Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. Proc. Natl. Acad. Sci. U.S.A., 2007-09-24;104(40):15817-22. 2007-09-24 [PMID: 17893340] (Neutralization, Mouse) |
Neutralization |
Mouse |
Saurer L, McCullough KC, Summerfield A In vitro induction of mucosa-type dendritic cells by all-trans retinoic acid. J. Immunol., 2007-09-15;179(6):3504-14. 2007-09-15 [PMID: 17785784] (ELISA Development, Neutralization, Porcine) |
ELISA Development, Neutralization |
Porcine |
Lamar JM, Iyer V, DiPersio CM Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes. J. Invest. Dermatol., 2007-08-30;128(3):575-86. 2007-08-30 [PMID: 17762853] (Neutralization, Mouse) |
Neutralization |
Mouse |
Alatrakchi N, Graham CS, van der Vliet HJ, Sherman KE, Exley MA, Koziel MJ Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses. J. Virol., 2007-03-21;81(11):5882-92. 2007-03-21 [PMID: 17376924] (Neutralization, Human) |
Neutralization |
Human |
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (Luminex Development, Human) |
Luminex Development |
Human |
Seo KS, Lee SU, Park YH, Davis WC, Fox LK, Bohach GA Long-term staphylococcal enterotoxin C1 exposure induces soluble factor-mediated immunosuppression by bovine CD4+ and CD8+ T cells. Infect. Immun., 2006-10-09;75(1):260-9. 2006-10-09 [PMID: 17030573] (Neutralization, Bovine) |
Neutralization |
Bovine |
Rosendahl AH, Forsberg G IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells. Kidney Int., 2006-09-13;70(9):1584-90. 2006-09-13 [PMID: 16969385] (Neutralization, Human) |
Neutralization |
Human |
Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction. Gut, 2006-07-13;56(2):243-52. 2006-07-13 [PMID: 16840505] (IHC-Fr, Neutralization, Human) |
IHC-Fr, Neutralization |
Human |
Funaba M, Nakaya K, Ikeda T, Murakami M, Tsuchida K, Sugino H Requirement of Smad3 for mast cell growth. Cell. Immunol., 2006-07-12;240(1):47-52. 2006-07-12 [PMID: 16839529] (Neutralization, Western Blot, Mouse) |
Neutralization, Western Blot |
Mouse |
Maeshima A, Vaughn DA, Choi Y, Nigam SK Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 2006-04-27;295(2):473-85. 2006-04-27 [PMID: 16643884] (Neutralization, Rat) |
Neutralization |
Rat |
Neurohr C, Nishimura SL, Sheppard D Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am. J. Respir. Cell Mol. Biol., 2006-03-30;35(2):252-9. 2006-03-30 [PMID: 16574941] (Neutralization, Human) |
Neutralization |
Human |
Koelle DM, Huang J, Hensel MT, McClurkan CL Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes. J. Virol., 2006-03-01;80(6):2863-72. 2006-03-01 [PMID: 16501095] (Neutralization, Human) |
Neutralization |
Human |
Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW, Chatterjee SK Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cells. J. Cell. Biochem., 2006-04-01;97(5):1036-51. 2006-04-01 [PMID: 16294321] (IHC-Fr, IHC-P, Mouse) |
IHC-Fr, IHC-P |
Mouse |
Fazzini M, Vallejo G, Colman-Lerner A, Trigo R, Campo S, Baranao JL, Saragueta PE Transforming growth factor beta1 regulates follistatin mRNA expression during in vitro bovine granulosa cell differentiation. J. Cell. Physiol., 2006-04-01;207(1):40-8. 2006-04-01 [PMID: 16245315] (Neutralization, Bovine) |
Neutralization |
Bovine |
Huang X, Zhu J, Yang Y Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta. J. Immunol., 2005-10-01;175(7):4283-91. 2005-10-01 [PMID: 16177068] (Neutralization, Mouse) |
Neutralization |
Mouse |
Close JL, Gumuscu B, Reh TA Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF beta signaling. Development, 2005-07-01;132(13):3015-26. 2005-07-01 [PMID: 15944186] (Neutralization, Rat) |
Neutralization |
Rat |
Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood, 2004-09-16;105(2):750-8. 2004-09-16 [PMID: 15374887] (Neutralization, Human) |
Neutralization |
Human |
Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, Qiuping Z, Junyan L, Zhang X, Jinquan T Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells. Immunology, 2004-06-01;112(2):274-89. 2004-06-01 [PMID: 15147571] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. J. Immunol., 2004-05-01;172(9):5753-64. 2004-05-01 [PMID: 15100322] (IHC-P, Western Blot, Primate - Macaca mulatta (Rhesus Macaque)) |
IHC-P, Western Blot |
Primate - Macaca mulatta (Rhesus Macaque) |
Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, Blazar BR, Porter SB In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood, 2004-03-18;104(2):453-61. 2004-03-18 [PMID: 15031211] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
Paliwal S, Shi J, Dhru U, Zhou Y, Schuger L P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2. Biochem. Biophys. Res. Commun., 2004-03-19;315(4):1104-9. 2004-03-19 [PMID: 14985127] (Western Blot, Mouse) |
Western Blot |
Mouse |
Kitani A, Fuss I, Pedersen A, Nawata H TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J. Immunol., 2004-01-15;172(2):834-42. 2004-01-15 [PMID: 14707053] (Neutralization, Human, Mouse) |
Neutralization |
Human, Mouse |
Chen , WanJun, Jin , Wenwen, Hardegen , Neil, Lei , Ke-Jian, Li , Li, Marinos , Nancy, McGrady , George, Wahl , Sharon M Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med, 2003-12-15;198(12):1875-86. 2003-12-15 [PMID: 14676299] (Neutralization, Mouse) |
Neutralization |
Mouse |
Koenen HJ, Fasse E, Joosten I IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression. J. Immunol., 2003-12-15;171(12):6431-41. 2003-12-15 [PMID: 14662842] (Neutralization, Human) |
Neutralization |
Human |
Kobayashi T, Iijima K, Kita H Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice. J. Immunol., 2003-06-01;170(11):5756-63. 2003-06-01 [PMID: 12759459] (Neutralization, Mouse) |
Neutralization |
Mouse |
Mookerjee A, Sen PC, Ghose AC Immunosuppression in hamsters with progressive visceral leishmaniasis is associated with an impairment of protein kinase C activity in their lymphocytes that can be partially reversed by okadaic acid or anti-transforming growth factor beta antibody. Infect. Immun., 2003-05-01;71(5):2439-46. 2003-05-01 [PMID: 12704114] (Neutralization, Hamster) |
Neutralization |
Hamster |
Feugate JE, 2019, Li Q, Wong L, Martins-Green M The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. e0216795, 2002-01-07;156(1):161-72. 2002-01-07 [PMID: 11781340] (Neutralization, Chicken) |
Neutralization |
Chicken |
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