Substance P Parameter Assay Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Substance P (SP, Neurokinin-1), is member of the Tachykinin peptide family and binds primarily to the Neurokinin 1 Receptor (NK1R, Substance P receptor, Tachykinin receptor 1) and with low affinity to the NK2 and NK3 receptors. Substance P is processed from preproTachykinin a, b, g and d isoforms that also generate other Tachykinins Neuropeptide K, Neurokinin A, Neurokinin B, and Neuropeptide G. Substance P is produced in the central nervous system, primary sensory neurons (C-type fibers), and endocrine cells of the intestinal mucosa. It triggers pain signals in the spinal cord dorsal horn as well as hypotension, tachycardia, release of inflammatory mediators, and direct antimicrobial action.

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Bovine, Guinea Pig, Rats.

Showing Publications 1 - 10 of 35. Show All 35 Publications. Collapse Publications.

Publications using KGE007	Applications	Species
Niebrzydowska-Tatus, M;Pe?ech, A;Bie?, K;Rekowska, AK;Doma?ska, A;Kimber-Trojnar, ?;Leszczy?ska-Gorzelak, B;Trojnar, M; Substance P Concentration in Gestational Diabetes and Excessive Gestational Weight Gain and Its Impact on Neonatal Anthropometry International journal of molecular sciences 2024-03-28 [PMID: 38612572] (Human)		Human
de Souza, S;Rosario Claudio, J;Sim, J;Inyang, KE;Dagenais, A;Monahan, K;Lee, B;Ramakrishnan, H;Parmar, V;Geron, M;Scherrer, G;Folger, JK;Laumet, G; Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response Brain, behavior, and immunity 2023-12-09 [PMID: 38081433] (Mouse)		Mouse
Q Chen, R Dong, L Zhang, M Zhang, X Xu, L Yu, Z Qiu Tracheobronchial-esophageal reflex initiates esophageal hypersensitivity and aggravates cough hyperreactivity in guinea pigs with esophageal acid infusion Respiratory physiology & neurobiology, 2022-03-28;301(0):103890. 2022-03-28 [PMID: 35358761] (Guinea Pig)		Guinea Pig
JH Park, CH Lee, HD Ham, ES Choi, C Lee, S Lee Analgesic effects of a 5-HT3 receptor antagonist in an animal model of complex regional pain syndrome European review for medical and pharmacological sciences, 2021-11-01;25(22):7051-7057. 2021-11-01 [PMID: 34859869] (Rats)		Rats
J Cheng, Z Xie, S Wang, S Wen, S Niu, C Shi, L Yu, X Xu Cough hypersensitivity in patients with metabolic syndrome: a clinical finding and its possible mechanisms BMC pulmonary medicine, 2021-09-06;21(1):284. 2021-09-06 [PMID: 34488706] (Human)		Human
F Corrigan, I Cernak, K McAteer, SC Hellewell, JV Rosenfeld, RJ Turner, R Vink NK1 antagonists attenuate tau phosphorylation after blast and repeated concussive injury Scientific Reports, 2021-04-23;11(1):8861. 2021-04-23 [PMID: 33893374] (Rat)		Rat
YC Liu, GH Yam, MT Lin, E Teo, SK Koh, L Deng, L Zhou, L Tong, JS Mehta Comparison of tear proteomic and neuromediator profiles changes between small incision lenticule extraction (SMILE) and femtosecond laser-assisted in-situ keratomileusis (LASIK) Journal of advanced research, 2020-11-05;29(0):67-81. 2020-11-05 [PMID: 33842006] (Human)		Human
SE Lee, SJ Lee, SE Kim, K Kim, B Cho, K Roh, SC Kim Intravenous allogeneic umbilical cord blood-derived mesenchymal stem cell therapy in recessive dystrophic epidermolysis bullosa patients JCI Insight, 2021-01-25;6(2):. 2021-01-25 [PMID: 33491668] (Human)		Human
X Zeng, C Xu, X Xu, Y Zhang, Y Huang, X Huo Elevated lead levels in relation to low serum neuropeptide Y and adverse behavioral effects in preschool children with e-waste exposure Chemosphere, 2020-12-21;269(0):129380. 2020-12-21 [PMID: 33383249] (Human)		Human
A Yamada, Y Sato, T Horike, M Miyanaga, DH Wang Effects of a Forest Walk on Urinary Dityrosine and Hexanoyl-Lysine in Young People: A Pilot Study Int J Environ Res Public Health, 2020-07-10;17(14):. 2020-07-10 [PMID: 32664406] (Human)		Human
HK Lee, KW Kim, JS Ryu, HJ Jeong, SM Lee, MK Kim Bilateral Effect of the Unilateral Corneal Nerve Cut on Both Ocular Surface and Lacrimal Gland Invest. Ophthalmol. Vis. Sci., 2019-01-02;60(1):430-441. 2019-01-02 [PMID: 30703211] (Mouse)		Mouse
Q Li, X Wu, Y Yang, Y Zhang, F He, X Xu, Z Zhang, L Tao, C Luo Tachykinin NK1 receptor antagonist L-733,060 and substance P deletion exert neuroprotection through inhibiting oxidative stress and cell death after traumatic brain injury in mice Int. J. Biochem. Cell Biol., 2018-12-26;0(0):. 2018-12-26 [PMID: 30593954] (Mouse)		Mouse
Y Xu, C Huang, H Deng, J Jia, Y Wu, J Yang, W Tu TRPA1 and substance P mediate stress induced duodenal lesions in water immersion restraint stress rat model Turk J Gastroenterol, 2018-11-01;29(6):692-700. 2018-11-01 [PMID: 30381276] (Mouse)		Mouse
Li Z, Luo T, Ning X, Xiong C, Wu A Neurokinin-1 receptor antagonism improves postoperative neurocognitive disorder in mice. Neurosci Lett, 2018-09-28;687(0):189-195. 2018-09-28 [PMID: 30273701] (Mouse)		Mouse
DSC Butler, I Ambite, K Nagy, C Cafaro, A Ahmed, A Nadeem, N Filenko, TH Tran, KE Andersson, B Wullt, M Puthia, C Svanborg Neuroepithelial control of mucosal inflammation in acute cystitis Sci Rep, 2018-07-20;8(1):11015. 2018-07-20 [PMID: 30030504] (Mouse)		Mouse
L Lorente, MM Martín, A Pérez-Ceja, J Ferreres, J Solé-Violá, L Labarta, C Díaz, A Jiménez Sustained Low Serum Substance P Levels in Non-Surviving Septic Patients Int J Mol Sci, 2017-07-15;18(7):. 2017-07-15 [PMID: 28714876] (Human)		Human
L Xiao, M Ding, A Fernandez, P Zhao, L Jin, X Li Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors Eur Cell Mater, 2017-05-09;33(0):279-293. 2017-05-09 [PMID: 28485773] (Mouse)		Mouse
AJ Sandweiss, MI McIntosh, A Moutal, R Davidson-K, J Hu, AK Giri, T Yamamoto, VJ Hruby, R Khanna, TM Largent-Mi, TW Vanderah Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential Mol. Psychiatry, 2017-05-09;0(0):. 2017-05-09 [PMID: 28485408] (Rat)		Rat
Y Okamura, S Mishima, JI Kashiwakur, T Sasaki-Sak, S Toyoshima, K Kuroda, S Saito, Y Tokuhashi, Y Okayama The dual regulation of substance P-mediated inflammation via human synovial mast cells in rheumatoid arthritis Allergol Int, 2017-03-31;0(0):. 2017-03-31 [PMID: 28366675] (Human)		Human
JA Singh, S Noorbalooc, KL Knutson Cytokine and neuropeptide levels are associated with pain relief in patients with chronically painful total knee arthroplasty: a pilot study BMC Musculoskelet Disord, 2017-01-14;18(1):17. 2017-01-14 [PMID: 28088207] (Human)		Human
Sphenopalatine Ganglion Acupuncture Improves Nasal Ventilation and Modulates Autonomic Nervous Activity in Healthy Volunteers: A Randomized Controlled Study Sci Rep, 2016-07-18;6(0):29947. 2016-07-18 [PMID: 27425415] (Human)		Human
M E Olson Efficacy of oral meloxicam suspension for prevention of pain and inflammation following band and surgical castration in calves BMC Vet Res, 2016-06-13;12(1):102. 2016-06-13 [PMID: 27295955] (Bovine)		Bovine
A Denes Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production Brain Behav. Immun., 2016-04-06;57(0):10-20. 2016-04-06 [PMID: 27060191] (Mouse)		Mouse
Liu , Boyi, Escalera , Jasmine, Balakrishna , Shrilath, Fan , Lu, Caceres , Ana I, Robinson , Eve, Sui , Aiwei, McKay , M Craig, McAlexander , M Allen, Herrick , Christin, Jordt , Sven E TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. FASEB J, 2013-05-30;27(9):3549-63. 2013-05-30 [PMID: 23722916] (Mouse)		Mouse
Kempuraj D, Twait E, Williard D, Yuan Z, Meyerholz D, Samuel I The novel cytokine interleukin-33 activates acinar cell proinflammatory pathways and induces acute pancreatic inflammation in mice. PLoS ONE, 2013-02-13;8(2):e56866. 2013-02-13 [PMID: 23418608] (Mouse, Rat)		Mouse, Rat
Chauhan VS, Kluttz JM Prophylactic and Therapeutic Targeting of the Neurokinin-1 Receptor Limits Neuroinflammation in a Murine Model of Pneumococcal Meningitis. J. Immunol., 2011-05-11;0(0):. 2011-05-11 [PMID: 21562162] (Mouse)		Mouse
Lee JK, Song YS, Shin JS, Kwon YS, Shin MS, Kim JC The change of cytokines in tear and blood after different pterygium operation. Cytokine, 2009-12-08;49(2):148-54. 2009-12-08 [PMID: 20004113] (Human)		Human
Akazawa T, Kwatra SG, Goldsmith LE, Richardson MD, Cox EA, Sampson JH, Kwatra MM A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas. J. Neurochem., 2009-03-11;109(4):1079-86. 2009-03-11 [PMID: 19519779] (Human)		Human
Desouza IA, Camargo EA, Mariano NS, Optiz-Neto JB, Resende JS, Mello GC, Costa SK, De Nucci G, Antunes E Role of sensory innervation in the rat pulmonary neutrophil recruitment induced by staphylococcal enterotoxins type A and B. Eur. J. Pharmacol., 2009-04-16;613(1):128-34. 2009-04-16 [PMID: 19375418] (Rat)		Rat
Templeton A, Nguyen G, Ash JD, Straub RH, Carr DJ Chemical sympathectomy increases susceptibility to ocular herpes simplex virus type 1 infection. J. Neuroimmunol., 2008-05-20;197(1):37-46. 2008-05-20 [PMID: 18495255] (Mouse)		Mouse
Dansereau MA, Gosselin RD, Pohl M, Pommier B, Mechighel P, Mauborgne A, Rostene W, Kitabgi P, Beaudet N, Sarret P, Melik-Parsadaniantz S Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. J. Neurochem., 2008-04-17;106(2):757-69. 2008-04-17 [PMID: 18419759] (Rat)		Rat
Shigematsu N, Fukuda T, Yamamoto T, Nishioku T, Yamaguchi T, Himeno M, Nakayama KI, Tsukuba T, Kadowaki T, Okamoto K, Higuchi S, Yamamoto K Association of cathepsin E deficiency with the increased territorial aggressive response of mice. J. Neurochem., 2008-01-21;105(4):1394-404. 2008-01-21 [PMID: 18221376] (Mouse)		Mouse
Im HJ, Li X, Muddasani P, Kim GH, Davis F, Rangan J, Forsyth CB, Ellman M, Thonar EJ Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes. J. Cell. Physiol., 2008-05-01;215(2):452-63. 2008-05-01 [PMID: 17960584] (Human)		Human
Tessier J, Green C, Padgett D, Zhao W, Schwartz L, Hughes M, Hewlett E Contributions of histamine, prostanoids, and neurokinins to edema elicited by edema toxin from Bacillus anthracis. Infect. Immun., 2007-01-29;75(4):1895-903. 2007-01-29 [PMID: 17261611] (Human)		Human
Bruno MA, Cuello AC Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade. Proc. Natl. Acad. Sci. U.S.A., 2006-04-17;103(17):6735-40. 2006-04-17 [PMID: 16618925] (Rat)		Rat
Show All 35 Publications. Collapse Publications.

Array KGE007

• Substance P Antibodies
• Substance P ELISAs