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STEP Antibody [Janelia Fluor® 585]

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Summary
Product Discontinued
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    • Catalog Number
      NBP2-81893JF585
    • Availability
      Product Discontinued

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STEP Antibody [Janelia Fluor® 585] Summary

Immunogen
STEP antibody was raised against an 18 amino acid peptide near the amino terminus of human STEP. The immunogen is located within amino acids 180 - 230 of STEP. Amino Acid Squence: LRTPPEPPTPLPPEDRRQ
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTPN5
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for STEP Antibody [Janelia Fluor® 585]

  • EC 3.1.3.48
  • FLJ14427
  • Neural-specific protein-tyrosine phosphatase
  • protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
  • protein-tyrosine phosphatase striatum-enriched
  • PTPN5
  • STEP
  • STEPPTPSTEP
  • Striatum-enriched protein-tyrosine phosphatase
  • tyrosine-protein phosphatase non-receptor type 5

Background

The protein tyrosine phosphatase non-receptor type 5 or striatum-enriched protein-tyrosine phosphatase (STEP) protein is part of a family of protein tyrosine phosphatases enriched within the CNS, and is a key component of the NMDAR complex. It is expressed within dopaminoceptive neurons in the CNS and particularly enriched within the basal ganglia and related structures. STEP61 is the membrane-associated isoform and STEP46 is the cytosolic protein. In response to transient hypoxia-ischemia in the brain, STEP61 is proteolytically cleaved by calpain, thereby releasing a smaller isoform, STEP33.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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STEP Antibody
[Janelia Fluor®
NBP2-81893JF585
STEP Antibody [Janelia Fluor® 585]
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC

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Bioinformatics

Gene Symbol PTPN5