p38 alpha Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses, such as UV irradiation and heat shock. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). p38 MAPK is involved in the regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, and indirectly CREB via activation of MSK1. The p38 MAPK protein also plays a role in cell differentiation, autophagy and apoptosis. Mkk3 and SEK can activate p38 MAPK by phosphorylation at Thr180 and Tyr182, which in turn activates the MAPKAP kinase 2 and regulating phosphorylation of ATF2, Mac and MEF2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Xenograft.

We have publications tested in 5 applications: Flow Cytometry, IHC, IHC-P, Simple Western, Western Blot.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using AF8691	Applications	Species
Ting Niu, Zhiying Wei, Jiao Fu, Shu Chen, Ru Wang, Yuya Wang et al. Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway Frontiers in Pharmacology 2023-01-04 [PMID: 36686679]
M ?witalska, B Filip-Psur, M Milczarek, M Psurski, A Moszy?ska, AM D?browska, M Gawro?ska, K Krzymi?ski, M Bagi?ski, R Bartoszews, J Wietrzyk Combined anticancer therapy with imidazoacridinone C-1305 and paclitaxel in human lung and colon cancer xenografts-Modulation of tumour angiogenesis Oncogene, 2022-06-14;0(0):. 2022-06-14 [PMID: 35701366] (Simple Western, Xenograft)	Simple Western	Xenograft
SA Harper, JR Bassler, S Peramsetty, Y Yang, LM Roberts, D Drummer, RT Mankowski, C Leeuwenbur, K Ricart, RP Patel, MM Bamman, SD Anton, BC Jaeger, TW Buford Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial Exp Gerontol, 2020-10-15;0(0):111111. 2020-10-15 [PMID: 33068691] (Flow Cytometry, Human)	Flow Cytometry	Human
M Iba, C Kim, J Florio, M Mante, A Adame, E Rockenstei, S Kwon, R Rissman, E Masliah Role of Alterations in Protein Kinase p38&gamma in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and &alpha-Synuclein Transgenic Models Front Neurosci, 2020-03-31;14(0):286. 2020-03-31 [PMID: 32296304] (IHC, Human, Mouse)	IHC	Human, Mouse
Zhang Y, Beketaev I, Segura AM et al. Contribution of Increased Expression of Yin Yang 2 to Development of Cardiomyopathy Front Mol Biosci 3/3/2020 [PMID: 32195266]
Michael Torzewski Selective p38? MAP kinase/MAPK14 inhibition in enzymatically-modified LDL-stimulated human monocytes: implications for atherosclerosis FASEB J., 2016-11-08;0(0):. 2016-11-08 [PMID: 27871059] (IHC-P, Human)	IHC-P	Human
A J Browne, A Göbel, S Thiele, L C Hofbauer, M Rauner, T D Rachner p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells Cell Death & Disease 2016-02-25 [PMID: 26913608]
Poulsen RC, Knowles HJ, Carr AJ et al. Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure. Cell Death Dis 2/20/2014 [PMID: 24556689]
Manuel A. F. V. Gonçalves, Josephine M. Janssen, Maarten Holkers, Antoine A. F. de Vries Rapid and Sensitive Lentivirus Vector-Based Conditional Gene Expression Assay to Monitor and Quantify Cell Fusion Activity PLoS ONE 2010-06-03 [PMID: 20532169]
Aychek T, Miller K, Sagi-Assif O, Levy-Nissenbaum O, Israeli-Amit M, Pasmanik-Chor M, Jacob-Hirsch J, Amariglio N, Rechavi G, Witz IP E-selectin regulates gene expression in metastatic colorectal carcinoma cells and enhances HMGB1 release. Int. J. Cancer, 2008-10-15;123(8):1741-50. 2008-10-15 [PMID: 18324679] (Western Blot, Human)	Western Blot	Human
Whittall T, Wang Y, Younson J, Kelly C, Bergmeier L, Peters B, Singh M, Lehner T Interaction between the CCR5 chemokine receptors and microbial HSP70. Eur. J. Immunol., 2006-09-01;36(9):2304-14. 2006-09-01 [PMID: 16909434] (Western Blot, Human)	Western Blot	Human
Show All 11 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Human	10/24/2018	View Summary Application Western Blot Sample Tested Human breast cancer cells Species Human Lot GIG0915111

Array AF8691

• p38 alpha Antibodies
• p38 alpha Lysates
• p38 alpha Proteins
• p38 alpha ELISAs
• p38 alpha Proteins and Enzyme