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SOX11 Antibody (SOX11/7236) [Janelia Fluor® 549]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
SOX11/7236
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 549

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-14182AF350
Alexa Fluor 405
NBP3-14182AF405
Alexa Fluor 488
NBP3-14182AF488
Alexa Fluor 532
NBP3-14182AF532
Alexa Fluor 594
NBP3-14182AF594
Alexa Fluor 647
NBP3-14182AF647
Alexa Fluor 700
NBP3-14182AF700
Alexa Fluor 750
NBP3-14182AF750
Allophycocyanin
NBP3-14182APC
Biotin
NBP3-14182B
CoraFluor 1
NBP3-14182CL1
DyLight 350
NBP3-14182UV
DyLight 405
NBP3-14182V
DyLight 488
NBP3-14182G
DyLight 550
NBP3-14182R
DyLight 594
NBP3-14182DL594
DyLight 650
NBP3-14182C
DyLight 680
NBP3-14182FR
DyLight 755
NBP3-14182IR
FITC
NBP3-14182F
HRP
NBP3-14182H
Janelia Fluor 525
NBP3-14182JF525
Janelia Fluor 585
NBP3-14182JF585
Janelia Fluor 635
NBP3-14182JF635
Janelia Fluor 646
NBP3-14182JF646
Janelia Fluor 669
NBP3-14182JF669
PE
NBP3-14182PE
PerCP
NBP3-14182PCP
Unconjugated
NBP3-13779-100ug
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP3-13779-100ug
Azide and BSA Free
NBP3-14182
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SOX11 Antibody (SOX11/7236) [Janelia Fluor® 549] Summary

Immunogen
Recombinant fragment (around aa50-200) of human SOX11 protein (exact sequence is proprietary) (Uniprot: P35716 )
Localization
Nucleus
Marker
Mantle Cell Lymphoma Marker
Specificity
Recognizes a protein of ~47kDa, identified as SOX11. This monoclonal antibody is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5%-10% of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
SOX11
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for SOX11 Antibody (SOX11/7236) [Janelia Fluor® 549]

  • SOX11
  • SRY (sex determining region Y)-box 11
  • SRY (sex-determining region Y)-box 11
  • SRY-related HMG-box gene 11
  • transcription factor SOX-11

Background

SOX11 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Western Blot SRY Antibody (1G4) - BSA Free
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SOX11 Antibody
(SOX11/7236) [Janelia ...
NBP3-14182JF549
SOX11 Antibody (SOX11/7236) [Janelia Fluor® 549]
Species: Hu
Applications: IHC

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Secondary Antibodies

 

Isotype Controls

Additional SOX11 Products

Blogs on SOX11.

Check out the latest blog posts on SOX11.
SOX-11 seals your fate
The SOX-11 transcription factor is a member of the SOX family known to be involved in embryonic development regulation and cell fate determination. The protein acts as a transcriptional regulator and appears to modulate fundamental aspects of normal e...  Read full blog post.
Read our latest blog and use the new citation tool on bio-techne.com

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SOX2 Antibody [Unconjugated]
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Bioinformatics

Gene Symbol SOX11