SOD2/Mn-SOD Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Superoxide Dismutases (SODs), originally identified as Indophenoloxidases (IPOs), are enzymes that catalyze the conversion of naturally occurring but harmful superoxide radicals into molecular oxygen and hydrogen peroxide. Superoxide Dismutases 2 (SOD2, also known as Manganese (Mn) SOD, mitochondrial SOD and IPO-B) is an intramitochondrial 23 kDa protein that associates as a homotetramer. Each SOD2 monomer binds one Mn²⁺ ion. Oxidative stress has been implicated in many diseases and the chief source of reactive oxygen species within the cell is the mitochondrion. SOD2 is a free radical scavenging enzyme that protects against damage from superoxide produced as a byproduct of oxidative phosphorylation and protects the integrity of mitochondrial enzymes susceptible to inactivation by superoxide. Over aa 25‑222, human SOD2 shows 94% and 93% identity to mouse and rat SOD2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 4 of 4.

Publications using AF3419	Applications	Species
Abigail G. Casso, Nicholas S. VanDongen, Rachel A. Gioscia‐Ryan, Zachary S. Clayton, Nathan T. Greenberg, Brian P. Ziemba et al. Initiation of 3,3‐dimethyl‐1‐butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice The Journal of Physiology 11/1/2022 [PMID: 36111692]
H Fujiyoshi, T Egawa, E Kurogi, T Yokokawa, K Kido, T Hayashi TLR4-Mediated Inflammatory Responses Regulate Exercise-Induced Molecular Adaptations in Mouse Skeletal Muscle International Journal of Molecular Sciences, 2022-02-07;23(3):. 2022-02-07 [PMID: 35163799] (Western Blot, Mouse)	Western Blot	Mouse
Vuong Cat Khanh, Toshiharu Yamashita, Kinuko Ohneda, Chiho Tokunaga, Hideyuki Kato, Motoo Osaka et al. Rejuvenation of mesenchymal stem cells by extracellular vesicles inhibits the elevation of reactive oxygen species Scientific Reports 10/14/2020 [PMID: 33057147]
Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma Cells PLoS ONE, 2016-11-30;11(11):e0167323. 2016-11-30 [PMID: 27902770] (Western Blot, Human)	Western Blot	Human

Array AF3419

• SOD2/Mn-SOD Antibodies
• SOD2/Mn-SOD Lysates
• SOD2/Mn-SOD Proteins
• SOD2/Mn-SOD ELISA