SOCS-3 Antibody Summary
Immunogen |
A portion of amino acids 110-160 from human SOCS3 was used as the immunogen for this antibody. |
Predicted Species |
Porcine (94%), Chimpanzee (100%), Orangutan (100%), Rhesus Macaque (100%). Backed by our 100% Guarantee. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
SOCS3 |
Purity |
Immunogen affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry
- Immunohistochemistry-Paraffin 5ug/ml~
- Western Blot 1-5ug/ml
|
Reactivity Notes
The amino acid sequence used as immunogen for this antibody is 100% homologous in rhesus monkey, orangutan, european pole-cat, and chimpanzee; 94% in new world monkey and pig; 89% in panda, dog, chinese hamster, and horse; 83% in cow, african bush elephant, mouse, sheep, and rat; and 61% homologous in guinea pig.
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
0.2 ml PBS and 0.05% BSA |
Preservative |
0.05% Sodium Azide |
Concentration |
0.5 mg/ml |
Purity |
Immunogen affinity purified |
Alternate Names for SOCS-3 Antibody
Background
SOCS3 is a member of the suppressor of cytokine signaling family with a molecular weight of ~ 25 kDa. It is also an SSI or stat-induced stat inhibitor protein. IL-6, for example, induces SOCS3 expression and in turn SOCS3 negatively regulates IL-6 induced immune signaling and inflammatory pathways. SOCS3 is also induced by IL-10 and IFNgamma (1-3). SOCS3 plays an important role in the initial stages of B-cell development and differentiation (1). IL-6, IL-10, and IFNgamma feedback loops and likely involvement of SOCS3 may also be critical in controlling and fine-tuning the inflammatory responses of activated macrophages through TLR ligands, a direct involvement therefore of SOCS3 in innate immune signaling pathways (4, 5) . SOCS3 antibody provides an opportunity to identify and clarify the SOCS3 feedback control mechanism in host defense, innate immunity and autoimmune inflammatory cascades.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Secondary Antibodies
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