SOCS-3 Antibody

SOCS3 is a member of the suppressor of cytokine signaling family with a molecular weight of ~ 25kDa. It is also an SSI or stat-induced stat inhibitor protein. IL-6, for example, induces SOCS3 expression and in turn SOCS3 negatively regulates IL-6 induced immune signaling and inflammatory pathways. SOCS3 is also induced by IL-10 and IFNgamma (1-3). SOCS3 plays an important role in the initial stages of B cell development and differentiation (1). IL-6, IL-10, and IFNgamma feedback loops and likely involvement of SOCS3 may also be critical in controlling and fine-tuning the inflammatory responses of activated macrophages through TLR ligands, a direct involvement therefore of SOCS3 in innate immune signaling pathways (4, 5). SOCS3 antibody provides an opportunity to identify and clarify the SOCS3 feedback control mechanism in host defense, innate immunity or autoimmune inflammatory cascades.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP2-27116

• SOCS-3 Antibodies
• SOCS-3 Proteins