SLC16A3 Antibody

Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs),which function as proton symports and are stereoselective for L-lactate.The MCT family consists of at least eight members, MCT1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT1 is widely expressed and is the major form of MCTs in tumor cells and erythrocytes. MCT2 is highly expressed in liver and testis, while MCT3 and MCT4 are predominantly expressed in skeletal muscle.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 6 applications: IB, ICC/IF, IF/IHC, IHC-Fr, IHC-P, WB.

Showing Publications 1 - 6 of 6.

Publications using NBP1-81251	Applications	Species
Lai YC, Hsieh CY, Lu KY Et al. Monitoring Early Glycolytic Flux Alterations Following Radiotherapy in Cancer and Immune Cells: Hyperpolarized Carbon-13 Magnetic Resonance Imaging Study Metabolites 2021-08-06 [PMID: 34436459] (WB, Human)	WB	Human
Murakami R, Chiba Y, Nishi N et al. Immunoreactivity of receptor and transporters for lactate located in astrocytes and epithelial cells of choroid plexus of human brain Neurosci Lett 2020-11-16 [PMID: 33212210] (IF/IHC, WB, ICC/IF, Human) Details: Immunofluorescence analysis and immunohistochemical analysis of human brain samples. Western blot analysis performed in HeLa and HT-29.	IF/IHC, WB, ICC/IF	Human
Lahiguera A, HyroSSovA P, Figueras A et al. Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors EMBO Mol Med 2020-05-13 [PMID: 32400970] (IHC-P, Mouse)	IHC-P	Mouse
Ilina Elena I, Armento Angela, Sanchez Leticia Garea et al. Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux. Oncotarget 2017-06-27 [PMID: 28978054] (IB, Human)	IB	Human
Silagi ES, Schoepflin ZR, Seifert EL et al. Bicarbonate Recycling by HIF-1-dependent Carbonic Anhydrase isoforms 9 and 12 is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells J. Bone Miner. Res. 2017-09-23 [PMID: 28940640] (Human)		Human
Nijland PG, Michailidou I, Witte ME et al. Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions. Glia 2014-04-01 [PMID: 24692237] (IHC-Fr, Human)	IHC-Fr	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Human	06/04/2015	View Summary Application Western Blot Species Human

Array NBP1-81251

• SLC16A3 Antibodies
• SLC16A3 ELISA Kits
• SLC16A3 Protein