SH2D2A Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

SH2D2A (SH2 domain-containing protein 2A; also TSAd and VRAP) is a 52 kDa protein best described as a multifunctional intracellular adaptor molecule. It is expressed in activated CD4⁺ and CD8⁺ T cells, endothelial cells, and fibroblasts. SH2D2A is found in both cytoplasm and nucleus, and has multiple binding partners. After TCR activation, SH2D2A interacts with LCK, prolonging its activity. It also binds to SMAD2 and SMAD3, and constitutively interacts with PI3K and PLC gamma , thus participating in VEGF:KDR signaling. Human SH2D2A is 389 amino acids (aa) in length and contains one SH2 domain (aa 95‑186) and a Pro-rich region (aa 187‑389). Phosphorylation occurs on Y39, Y216 and Y305, and on S217 and S296.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Immunoprecipitation, Simple Western, Western Blot.

Showing Publications 1 - 3 of 3.

Publications using AF6020	Applications	Species
Tomkowicz B, Walsh E et al. TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway. PLoS One 2024-10-22 [PMID: 26492563] (Simple Western, Human)	Simple Western	Human
Sun Z, Li X, Massena S, Kutschera S, Padhan N, Gualandi L, Sundvold-Gjerstad V, Gustafsson K, Choy WW, Zang G, Quach M, Jansson L, Phillipson M, Abid MR, Spurkland A, Claesson-Welsh L VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd. J. Exp. Med., 2012-06-11;209(7):1363-77. 2012-06-11 [PMID: 22689825] (Immunoprecipitation, Western Blot, Human, Mouse)	Immunoprecipitation, Western Blot	Human, Mouse
Ruan GX, Kazlauskas A Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J., 2012-02-10;31(7):1692-703. 2012-02-10 [PMID: 22327215] (Western Blot, Human)	Western Blot	Human

Array AF6020

• SH2D2A Antibodies
• SH2D2A Lysates
• SH2D2A Proteins