INSIG-1 Antibody - BSA Free

Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 2 applications: B/N, WB.

Showing Publications 1 - 7 of 7.

Publications using NB110-55244	Applications	Species
Egawa N, Izumi Y, Suzuki H et al. TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2 Scientific Reports 2022-05-14 [PMID: 35568729] (B/N, WB)	B/N, WB
Segatto M, Di Giovanni AL, Marino M, Pallottini V. Analysis of the protein network of cholesterol homeostasis in different brain regions: an age and sex dependent perspective J Cell Physiol 2012-12-31 [PMID: 23280554] (WB, Rat)	WB	Rat
Segatto M, Trapani L, Lecis C, Pallottini V. Regulation of cholesterol biosynthetic pathway in different regions of the rat central nervous system. Acta Physiol (Oxf). 2012-05-16 [PMID: 22591135] (WB, Rat)	WB	Rat
Trapani L, Segatto M, Simeoni V et al. Short- and long-term regulation of 3-hydroxy 3-methylglutaryl coenzyme A reductase by a 4-methylcoumarin Biochimie 2011-07-01 [PMID: 21530605] (WB, Human)	WB	Human
De Marinis E, Martini C, Trentalance A et al. Sex differences in hepatic regulation of cholesterol homeostasis. J Endocrinol;198(3):635-43. 2008-09-01 [PMID: 18603607]
Beehler K MiR-1908 Is a Cholesterol Responsive MicroRNA Implicated In Cholesterol Regulation Thesis 2020-01-01 (WB, Human)	WB	Human
Nakanishi T, Tanaka R, Tonai S Et al. LH induces de novo cholesterol biosynthesis via SREBP activation in granulosa cells during ovulation in female mice Endocrinology 2021-08-25 [PMID: 34431998]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: kong yang	WB	Human	07/15/2018	View Summary Application Western Blot Sample Tested U251 glioma cell line; whole cell lysate,U87 whole cell lysates Species Human Lot A Comments Comments the molecular weight of the insig1 protein in the U251 lysate is about 25-26kD。(not the 30kD indicated on the manual). The strips are clearly visible and meet the submission requirements. The dilution ratio is (2ug/ml)

Array NB110-55244

• INSIG-1 Antibodies
• INSIG-1 Lysates
• INSIG-1 Protein