I would like to order SREBP-1 antibody, catalog number NB600-582. I am wondering if it might cross react with MDCK-C cells from dog?

We have not tested NB600-582 with any dog samples, and cannot guarantee that it will cross-react. However, if you are interested in trying this antibody with dog samples you would be eligible for our Innovators Reward Program .

I am looking for SREBF1 antibodies that can cross-react with Zebrafish srebf1. I am wondering whether you have any SREBF1 antibodies that have been tested for zebra fish or have high sequence identity in the immunogen region?

Unfortunately we do not have any antibodies that have been tested in zebra fish. I have included the immunogen sequence for the antibodies it might be worth considering. I am not sure exactly what the zebra fish sequence is, I was unable to find it on uniprot.org, so I was unable to check the homology. The following antibodies all have available sample sizes. If you decide to try one you would qualify for our Innovator's Reward Program . NB600-582: 301-407 aa, NB100-2215: 300-400 aa, NB100-60545: 700-800 aa

SREBP1 Antibody (2A4) - BSA Free (NB600-582): Novus Biologicals

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, Rt, Ca, Ch, Ha, Pm, SyHaSpecies Glossary
Applications	WB, Simple Western, IHC, KO
Clone	2A4
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated
Format	BSA Free
Concentration	1 mg/ml

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 NB600-582AF350

Alexa Fluor 405 NB600-582AF405

Alexa Fluor 488 NB600-582AF488

Alexa Fluor 532 NB600-582AF532

Alexa Fluor 594 NB600-582AF594

Alexa Fluor 647 NB600-582AF647

Alexa Fluor 700 NB600-582AF700

Alexa Fluor 750 NB600-582AF750

Allophycocyanin NB600-582APC

Biotin NB600-582B

DyLight 350 NB600-582UV

DyLight 405 NB600-582V

DyLight 488 NB600-582G

DyLight 550 NB600-582R

DyLight 594 NB600-582DL594

DyLight 650 NB600-582C

DyLight 680 NB600-582FR

DyLight 755 NB600-582IR

HRP NB600-582H

Janelia Fluor 549 NB600-582JF549

Janelia Fluor 646 NB600-582JF646

PE NB600-582PE

PerCP NB600-582PCP

mFluor Violet 450 SE NB600-582MFV450

mFluor Violet 500 SE NB600-582MFV500

mFluor Violet 610 SE NB600-582MFV610

Catalog# & Formulation	Size	Price
BSA Free NB600-582SS

Azide and BSA Free NBP2-80959

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	NB600-582AF350
Alexa Fluor 405	NB600-582AF405
Alexa Fluor 488	NB600-582AF488
Alexa Fluor 532	NB600-582AF532
Alexa Fluor 594	NB600-582AF594
Alexa Fluor 647	NB600-582AF647
Alexa Fluor 700	NB600-582AF700
Alexa Fluor 750	NB600-582AF750
Allophycocyanin	NB600-582APC
Biotin	NB600-582B
DyLight 350	NB600-582UV
DyLight 405	NB600-582V
DyLight 488	NB600-582G
DyLight 550	NB600-582R
DyLight 594	NB600-582DL594
DyLight 650	NB600-582C
DyLight 680	NB600-582FR
DyLight 755	NB600-582IR
HRP	NB600-582H
Janelia Fluor 549	NB600-582JF549
Janelia Fluor 646	NB600-582JF646
PE	NB600-582PE
PerCP	NB600-582PCP
mFluor Violet 450 SE	NB600-582MFV450
mFluor Violet 500 SE	NB600-582MFV500
mFluor Violet 610 SE	NB600-582MFV610

SREBP1 Antibody (2A4) - BSA Free

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SREBP1 Antibody (2A4) - BSA Free Summary

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Publications for SREBP1 Antibody (NB600-582)(60)

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Bioinformatics

Immunogen	6 His-tag fusion protein of human SREBP1 corresponding to amino acids 301-407. [UniProt# P36956]
Localization	Cytoplasmic and nuclear
Isotype	IgG1 Kappa
Clonality	Monoclonal
Host	Mouse
Gene	SREBF1
Purity	Protein G purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer	PBS
Preservative	0.05% Sodium Azide
Concentration	1 mg/ml
Purity	Protein G purified

Publications using NB600-582	Applications	Species
Saito K, Sekiya M, Kainoh K et al. Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity The Journal of biological chemistry 2023-06-05 [PMID: 37286039] (WB, Human)	WB	Human
Srinivasan MP, Bhopale KK, Caracheo AA et al. Dysregulated pancreatic lipid phenotype, inflammation and cellular injury in a chronic ethanol feeding model of hepatic alcohol dehydrogenase-deficient deer mice Life sciences 2023-06-01 [PMID: 37030615] (WB, Mouse)	WB	Mouse
Tajima O, Fujita Y, Ohmi Y et al. Ganglioside GM3 prevents high fat diet-induced hepatosteatosis via attenuated insulin signaling pathway PloS one 2023-02-24 [PMID: 36827398] (WB, Mouse)	WB	Mouse
Huang CY, Chen HW, Lo CW et al. Luteolin ameliorates palmitate-induced lipotoxicity in hepatocytes by mediating endoplasmic reticulum stress and autophagy Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023-01-01 [PMID: 36509263]
Chen YJ, Lo YH, Chen YT et al. Magnesium lithospermate B improves metabolic changes in high-fat diet-fed rats with metabolic syndrome Journal of Functional Foods. 2015-04-01 (WB, Rat) Details: SREBP1 antibody was used for WB application on lysates of liver tissue from rats that were fed different diet regimns as - normal diet control/NC, high-fat diet control/HC or HC+ MLB/Magnesium lithospermate B (MLB5-20/HC+5-20?mg/kg/day of MLB). Primary antibody was used at 1:1000 dilution in 5% skim milk and detected with HRP-conjugated secondary antibody - chemiluminescent HRP substrate (data shown in Fig. 4A).	WB	Rat
Cook J. Toward a Mechanistic Understanding of Hepatic Insulin Action and Resistance. Thesis. 2014-01-01 (WB, Mouse)	WB	Mouse
Liu M, Liu L, Guo H et al. Dominant-negative HNF1? mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D iScience 2023-09-01 [PMID: 37841581] (WB, Mouse)	WB	Mouse
Yang M, Mariano J, Su R et al. SARS-CoV-2 papain-like protease (PLpro) plays multiple roles in regulating cellular proteins in the endoplasmic reticulum The Journal of biological chemistry 2023-10-12 [PMID: 37838170] (WB, Human)	WB	Human
Zhu Y, Lei L, Wang X et al. Low abundance of insulin-induced gene 1 contributes to SREBP-1c processing and hepatic steatosis in dairy cows with severe fatty liver Journal of dairy science 2023-06-06 [PMID: 37291038] (WB, Bovine)	WB	Bovine
Fukuda M, Ogasawara Y, Hayashi H et al. Resveratrol Inhibits Proliferation and Induces Autophagy by Blocking SREBP1 Expression in Oral Cancer Cells Molecules (Basel, Switzerland) 2022-11-26 [PMID: 36500345] (WB, Human)	WB	Human
Sawamoto A, Doi K, Amakura Y et al. N-Caffeoyltryptophan enhances adipogenic differentiation in preadipocytes and improves glucose tolerance in mice Biochimica et Biophysica Acta (BBA) - General Subjects 2022-11-01 [PMID: 36460233] (WB, Mouse) Details: 1:1000 dilution WB	WB	Mouse
Li X, Su Q, Pan Y Overcharged lipid metabolism in mechanisms of antitumor by Tremella fuciformis‑derived polysaccharide International journal of oncology 2023-01-01 [PMID: 36416344] (WB, Mouse) Details: Dilutions: 1:1000	WB	Mouse
Urasaki Y, Le TT Functional Complementation of Anti-Adipogenic Phytonutrients for Obesity Prevention and Management Nutrients 2022-10-16 [PMID: 36297009] (WB, Simple Western, Human)	WB, Simple Western	Human
Qiao P, Jia Y, Ma A et al. Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice Frontiers in Pharmacology 2022-08-19 [PMID: 36059948]
Chiu CH, Chang CC, Lin JJ et al. Styrylpyrones from Phellinus linteus Mycelia Alleviate Non-Alcoholic Fatty Liver by Modulating Lipid and Glucose Metabolic Homeostasis in High-Fat and High-Fructose Diet-Fed Mice Antioxidants (Basel) 2022-04-30 [PMID: 35624762]
Zhou J, Lu Y, Jia Y Et al. Ketogenic Diet Ameliorates Lipid Dysregulation in Type 2 Diabetic Mice by Downregulating Hepatic Pescadillo 1 Mol Med 2022-01-04 [PMID: 34979900]
Zeng H, Qin H, Liao M et al. CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing Molecular metabolism 2021-12-30 [PMID: 34974159] (WB, Mouse)	WB	Mouse
Jin M, Zhang D, Zheng L et al. Lipopolysaccharide and tyloxapol accelerate the development of atherosclerosis in mice Lipids 2021-12-07 [PMID: 34875723] (WB, Mouse)	WB	Mouse
Aliluev A, Tritschler S, Sterr M et al. Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice Nature metabolism 2021-09-01 [PMID: 34552271] (WB, Mouse)	WB	Mouse
Ploner C, Rauchenwald T, Connolly CE et al. Oxidant therapy improves adipogenic differentiation of adipose-derived stem cells in human wound healing Stem cell research & therapy 2021-05-10 [PMID: 33971957] (WB, Human)	WB	Human
Zhang M, Ceyhan Y, Kaftanovskaya EM et al. INPP4B protects from metabolic syndrome and associated disorders Communications biology 2021-03-26 [PMID: 33772116] (WB, Mouse)	WB	Mouse
Bosc C, Broin N, Fanjul M et al. Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites Nat Commun 2020-08-13 [PMID: 32792483] (WB, Human)	WB	Human
Srinivasan MP, Bhopale KK, Caracheo AA et al. Pur Alpha regulates the induction of Znf179 transcription during neuronal differentiation Biochem Pharmacol 2020-10-01 [PMID: 32717227] (WB, Rat, Human)	WB	Rat, Human
Low JY, Brennen WN, Meeker AK et al. Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling Molecular Cancer Research 2020-09-01 [PMID: 32493699]
Shen B, Feng H et al. Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways. J Cell Mol Med 2020-01-05 [PMID: 32293113] (WB, Human)	WB	Human
Park Y, An M, Kim J, Lim Y Antiobesity effect of ethanolic extract of Ramulus mori in differentiated 3T3-L1 adipocytes and high-fat diet-induced obese mice Journal of Ethnopharmacology 2020-01-01 [PMID: 31904494] (WB, Mouse)	WB	Mouse
Inhibition of Hepatotoxicity by a LXR Inverse Agonist in a Model of Alcoholic Liver Disease Sengupta M, Griffett K, Flaveny C et al. ACS Pharmacol Transl Sci [PMID: 31696159] (WB, IHC-F, Mouse)	WB, IHC-F	Mouse
Lin R, Jia Y, Wu F et al. Combined Exposure to Fructose and Bisphenol A Exacerbates Abnormal Lipid Metabolism in Liver of Developmental Male Rats Int J Environ Res Public Health 2019-10-28 [PMID: 31661889] (WB, Rat)	WB	Rat
Gouw AM, Margulis K, Liu NS et al. The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth Cell Metab. 2019-08-19 [PMID: 31447321]
Yang N, Li C, Li H et al. Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells Front Pharmacol 2019-06-25 [PMID: 31297058] (WB, Human)	WB	Human
Pham DD, Bruelle C, Thi Do H et al. Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells Cell Death Dis 2019-07-11 [PMID: 31296846] (WB, Human)	WB	Human
Li Y, Xu Y, Jadhav K et al. Hepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis Arterioscler. Thromb. Vasc. Biol. 2019-08-01 [PMID: 31291759] (WB, Mouse)	WB	Mouse
Chuang WT, Liu YT, Huang CS et al. Benzyl Isothiocyanate and Phenethyl Isothiocyanate Inhibit Adipogenesis and Hepatosteatosis in Mice with Obesity Induced by a High-Fat Diet J. Agric. Food Chem. 2019-06-26 [PMID: 31240929] (WB, Mouse)	WB	Mouse
Li CC, Yen CC, Fan CT et al. 14-Deoxy-11,12-didehydroandrographolide suppresses adipogenesis of 3 T3-L1 preadipocytes by inhibiting CCAAT/enhancer-binding protein B activation and AMPK-mediated mitotic clonal expansion. Toxicol. Appl. Pharmacol. 2018-09-21 [PMID: 30248417] (WB, Mouse)	WB	Mouse
Ikenoue T, Terakado Y, Zhu C, Liu X. Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation. Sci Rep. 2018-01-31 [PMID: 29386660] (WB, Mouse)	WB	Mouse
Khound R, Shen J, Song Y et al. Phytoceuticals in Fenugreek Ameliorate VLDL Overproduction and Insulin Resistance via the Insig Signaling Pathway. Mol Nutr Food Res 2017-12-06 [PMID: 29210166] (Mouse)		Mouse
Yang Yingjie, Yang Qian, Yang Jian et al. Angiotensin II induces cholesterol accumulation and injury in podocytes. Scientific Reports 2017-09-06 [PMID: 28878222] (WB, Human)	WB	Human
Ahmad F, Patrick S, Sheikh T et al. TERT-EZH2 network regulates lipid metabolism and DNA damage responses in glioblastoma J. Neurochem. 2017-08-21 [PMID: 28833137] (WB, Mouse)	WB	Mouse
Janssens S, Ciapaite J, Wolters JC et al. An In Vivo Magnetic Resonance Spectroscopy Study of the Effects of Caloric and Non-Caloric Sweeteners on Liver Lipid Metabolism in Rats. Nutrients. 2017-05-10 [PMID: 28489050] (WB, Rat)	WB	Rat
Dungan CM, Li J, Williamson DL. Caloric Restriction Normalizes Obesity-Induced Alterations on Regulators of Skeletal Muscle Growth Signaling. Lipids 2016-06-11 [PMID: 27289530] (WB, Mouse)	WB	Mouse
Mahmood S, Birkaya B, Rideout TC, Patel MS. Lack of Mitochondria-generated acetyl-CoA by pyruvate dehydrogenase complex downregulates gene expression in hepatic de novo lipogenic pathway. Am. J. Physiol. Endocrinol. Metab. 2016-05-10 [PMID: 27166281] (WB, Mouse)	WB	Mouse
Goedeke L, Rotllan N, Canfran-Duque A et al. MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels. Nat Med 2015-11-01 [PMID: 26437365]
Casali BT, Corona AW, Mariani MM et al. Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease J. Neurosci. 2015-06-17 [PMID: 26085639] (WB, Mouse)	WB	Mouse
Dungan CM, Li Z, Wright DC, Williamson DL. Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle. Muscle Nerve 2015-04-29 [PMID: 25926238]
Li Z, Dungan Cm, Carrier B et al. Alpha-Lipoic Acid Supplementation Reduces mTORC1 Signaling in Skeletal Muscle from High Fat Fed, Obese Zucker Rats Lipids et al. 2014-12-01 [PMID: 25366515] (WB, Rat) Details: SREBP1 / SREBP1c antibody used for WB in nuclear and cytoplasmic fractions of skeletal muscles from High Fat Fed, Obese Zucker Rats supplemented or not with Alpha-Lipoic Acid (Fig. 3c and d)	WB	Rat
Rideout TC, Ramprasath V, Griffin JD et al. Phytosterols protect against diet-induced hypertriglyceridemia in Syrian golden hamsters. Lipids Health Dis 2014-01-06 [PMID: 24393244] (WB, Hamster)	WB	Hamster
Wen S, Jadhav KS, Williamson DL, Rideout TC. Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice. J Lipids 2013-01-01 [PMID: 23862065] (WB, Mouse)	WB	Mouse
Pajvani UB, Qiang L, Kangsamaksin T et al. Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability. Nat Med 2013-08-01 [PMID: 23832089] (WB, Mouse)	WB	Mouse
Raksaseri P, Chatsudthipong V, Muanprasat C, Soodvilai S. Activation of liver X receptors reduces cystic fibrosis transmembrane conductance regulator (CFTR)-mediated chloride transport in kidney collecting duct cells. Am J Physiol Renal Physiol 2013-05-29 [PMID: 23720350] (WB, Canine)	WB	Canine
Liu Y, Major AS, Zienkiewicz J et al. Nuclear Transport Modulation Reduces Hypercholesterolemia, Atherosclerosis, and Fatty Liver J Am Heart Assoc 2013-04-05 [PMID: 23563994] (WB, Mouse)	WB	Mouse
Herman MA, Peroni OD, Villoria J, Schon MR, Abumrad NA, Bluher M, Klein S, Kahn BB. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature;484(7394):333-8. 2012-04-19 [PMID: 22466288] (WB, Mouse)	WB	Mouse
Gosmain Y, Dif N, Berbe V, Loizon E, Rieusset J, Vidal H, Lefai E. Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues. J Lipid Res;46(4):697-705. 2005-04-01 [PMID: 15627654] (WB, Rat)	WB	Rat
Zhang Y, Hillgartner FB. Starvation and feeding a high-carbohydrate, low-fat diet regulate the expression sterol regulatory element-binding protein-1 in chickens.. J Nutr. 2004-09-01 [PMID: 15333705] (WB, Chicken) Details: SREBP2 antibody (clone 1D2) was used for WB analysis of nuclear and membrane fractions from livers of 10- 12 days old chickens subjected to 24 hours of starvation followed by feeding of high-carbohydrate, low-fat diet for 0, 5, and 24 hours (FIGURE 3). The antibody was also used for EMSA /GS (gel mobility shift assays) under similar experimental conditions on nuclear extracts from chick's liver tissue (FIGURE 5).	WB	Chicken
Demoulin JB, Ericsson J, Kallin A et al. Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins.. J Biol Chem. 2004-08-20 [PMID: 15213220] (WB, Human)	WB	Human
Kim HJ, Miyazaki M, Ntambi JM. Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism. J Lipid Res;43(10):1750-7. 2002-10-01 [PMID: 12364560]
Yabe D, Brown MS, Goldstein JL. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.. Proc Natl Acad Sci U S A. 2002-10-01 [PMID: 12242332] Details: SREBP2 antibody (clone 1D2) was used at 1-5ug/ml concentration in WB application on lysates of SRD-13A cells transfected with human pTK-HSV-BP-2 encoding wild-type HSV-tagged human SREBP-2 . The antibody detected the cleaved nuclear and uncleaved precursor forms of SREBP2 protein. See full text for detailed protocols and data images.
Yin L, Zhang Y, Hillgartner FB. Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes.. J Biol Chem. 2002-05-31 [PMID: 11907029] (WB, Chicken)	WB	Chicken
Shimano H, Shimomura I, Hammer RE, Herz J, Goldstein JL, Brown MS, Horton JD. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J Clin Invest;100(8):2115-24. 1997-10-15 [PMID: 9329978]
Sato R, Yang J, Wang X, Evans MJ, Ho YK, Goldstein JL, Brown MS. Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). J Biol Chem;269(25):17267-73. 1994-06-24 [PMID: 8006035] (WB, Human)	WB	Human
Sheng Z, Otani H, Brown MS, Goldstein JL. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc Natl Acad Sci U S A;92(4):935-8. 1995-02-14 [PMID: 7862668] (WB, Hamster)	WB	Hamster
Show All 60 Publications. Collapse Publications.

Gene Symbol	SREBF1
Entrez	6720(Human) 20787(Mouse) 78968(Rat)
Uniprot	P36956(Human)