SAT1 Antibody - BSA Free

SAT1 or spermidine/spermine N(1)-acetyltransferase 1 (also called SSAT, diamine acetyltransferase 1 and putrescine acetyltransferase) is a homodimeric cytoplasmic enzyme which belongs to acetyltransferase family and catalyzes acetylation of polyamines. SAT1's substrate specificity order is: norspermidine = spermidine >spermine > N(1)-acetylspermine > putrescine, and its activity is highly regulated that allows a fine attenuation of the intracellular polyamines concentrations via acetylation or polyamine export. Polyamines such as putrescine, spermidine and spermine are implicated in the regulation of cellular growth/proliferation (increased levels leads to cancer progression) and their levels are controlled by several catabolic enzymes which includes such as SAT1, APAO (acetylpolyamine oxidase) and SMO (spermine oxidase). Enhanced SSAT expression has been shown to be associated with apoptosis in cancer cells and SSAT was shown to decrease the expression of anti-apoptosis-related signaling proteins AKT and mTOR. SAT1 has also been implicated in the neurobiology of suicide and decreased SAT1 expression has been observed in several brain regions in suicide completers. Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 5 of 5.

Publications using NB110-41622	Applications	Species
Mossmann D, Müller C, Park S et al. Arginine reprograms metabolism in liver cancer via RBM39 Cell 2023-09-26 [PMID: 37804830] (WB, Mouse, Human)	WB	Mouse, Human
Fiches GN, Wu Z, Zhou D et al. Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection PLOS Pathogens 2022-04-29 [PMID: 35486659] (WB)	WB
Tate PM, Mastrodomenico V, Mounce BC Ribavirin Induces Polyamine Depletion via Nucleotide Depletion to Limit Virus Replication Cell Rep 2019-09-03 [PMID: 31484073]
Lane DJR, Bae DH, Siafakas AR et al. Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes Biochim. Biophys. Acta 2018-05-16 [PMID: 29777905] (WB)	WB
Liao C-P, Lasbury ME, Wang S-H et al. Pneumocystis Mediates Overexpression of Antizyme Inhibitor Resulting in Increased Polyamine Levels Apoptosis in Alveolar Macrophages. J Biol Chem;284(12):8174-8184. 2009-01-01 [PMID: 19158080] (WB, Rat)	WB	Rat

Array NB110-41622

• SAT1 Antibodies
• SAT1 Lysate
• SAT1 Proteins