RIPK1/RIP1 Antibody

RIP (Receptor Interacting Protein) is a 74 kD Ser/Thr kinase which interacts with CD95 (Fas/APO1) receptor and the tumor necrosis factor receptor (TNFR1). It is a cell death domain adapter protein which can bind to the adapter proteins TRADD, RAID (CRADD) and TRAF2. RIP contains an N terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C terminal region containing an intracellular death domain motif. RIP activates both p38 MAP Kinase and SAPK families. In vitro, RIP induces apoptosis, as well as SAPK/JNK and NF-kB activation. NF-kB activation through TRADD, TRAF2 and RIP can be triggered also by DR3/APO3 upon activation with APO3/Tweak ligand. DR4 and DR5 also use FADD, TRADD, and RIP in their signal transduction pathways. RIP deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age. RIP possesses kinase activity as it autophosphorylates itself on serine and threonine residues.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IP, WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-56160	Applications	Species
Coornaert I, Puylaert P, Marcasolli G et al. Impact of myeloid RIPK1 gene deletion on atherogenesis in ApoE-deficient mice Atherosclerosis 2021-02-01 [PMID: 33706083] (Human)		Human
Xie Yangchun, Zhu Shan, Zhong Meizuo et al. Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma. Gastroenterology 2017-07-02 [PMID: 28764929] (IP, WB, Human)	IP, WB	Human
Ratovitski EA. Phospho-Delta-Np63alpha-responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure FEBS Lett. 2015-04-21 [PMID: 25910754] (IP, WB, Human)	IP, WB	Human

Array NB100-56160

• RIPK1/RIP1 Antibodies
• RIPK1/RIP1 ELISA Kit
• RIPK1/RIP1 Lysate
• RIPK1/RIP1 Proteins