RelA/NFkB p65 [p Ser536] Antibody

p65 is a subunit of the nuclear factor kappa B. The transcription factor NFkB is widely recognized as a critical mediator of immune and inflammatory responses. In most cell types, NFkB is found in the cytoplasm where it is associated with an inhibitory protein known as IkB. An impressive variety of stimuli (tumor necrosis factor, interleukin 1, T cell activation signals, bacterial endotoxins, viral transforming proteins, certain growth factors and reactive oxygen intermediates) lead to the rapid nuclear accumulation of NFkB by the induced phosphorylation and subsequent degradation of IkB. In the nucleus, NFkB regulates genes encoding cytokines, cytokine receptors, cell adhesion molecules, proteins involved in coagulation and genes involved in cell growth control. Additionally, NFkB is thought to be an important transcriptional regulator for HIV. Growing evidence indicates that the dysregulation of NFkB may be key to a number of diseases including arthritis and other inflammatory diseases, Alzheimer's disease, atherosclerosis and cancer.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Fish.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 10 of 10.

Publications using NB100-82088	Applications	Species
Farrell K, Houle JD, et al. Systemic inhibition of soluble TNF with XPro1595 exacerbates a post-spinal cord injury depressive phenotype in female rats J. Neurotrauma 2019-05-08 [PMID: 31064292] (Mouse)		Mouse
Pal S, Nath P, Biswas S et al. Nonylphenol attenuates SOCS3 expression and M1 polarization in lipopolysaccharide-treated rat splenic macrophages Ecotoxicol. Environ. Saf. 2019-06-15 [PMID: 30870658] (WB, Rat)	WB	Rat
Halvarsson C, Rorby E, Eliasson P et al. Putative role of NF-kappa B but not HIF-1alpha in hypoxia-dependent regulation of oxidative stress in hematopoietic stem and progenitor cells Antioxid. Redox Signal. 2019-03-02 [PMID: 30827134] (WB, Mouse)	WB	Mouse
Chen Y, Wu Z, Yuan B et al. MicroRNA-146a-5p attenuates irradiation-induced and LPS-induced hepatic stellate cell activation and hepatocyte apoptosis through inhibition of TLR4 pathway. Cell Death Dis. 2018-01-18 [PMID: 29348414] (ICC/IF, Human)	ICC/IF	Human
Shapovalova M Molecular Imaging of Prostate Cancer Using Biomarker-Guided Strategies Thesis 2019-01-01
Farrell KF Neuroinflammation and Circuitry Changes in the Dorsal Raphe Nucleus with Depressive Phenotype after Spinal Cord Injury Thesis 2019-04-01 (Mouse)		Mouse
Ibrahim AG, Ciullo A, Li C et al. Engineered extracellular vesicles antagonize SARS-CoV-2 infection by inhibiting mTOR signaling Biomaterials and biosystems 2022-06-01 [PMID: 35187508] (ICC/IF)	ICC/IF
Mukherjee U, Samanta A, Biswas S et al. Bisphenol A-induced oxidative stress, hepatotoxicity and altered estrogen receptor expression in Labeo bata: impact on metabolic homeostasis and inflammatory response Ecotoxicology and Environmental Safety 2020-10-01 [PMID: 32800225] (WB, Fish)	WB	Fish
Zhang Y, Zhang S, Li B et al. Age-Related Changes in the Gut Microbiota Promote Atrial Fibrillation Research Square 2020-08-04 (WB, Rat)	WB	Rat
Mou KJ, Shen KF, Li YL et al. Adenosine A2A Receptor in Bone Marrow-Derived Cells Mediated Macrophages M2 Polarization via PPAR gamma-P65 Pathway in Chronic Hypoperfusion Situation Frontiers in aging neuroscience 2022-01-03 [PMID: 35046793] (WB, Mouse)	WB	Mouse

Array NB100-82088

• RelA/NFkB p65 Antibodies
• RelA/NFkB p65 Antibody Pack
• RelA/NFkB p65 ELISA Kits
• RelA/NFkB p65 Inhibitors
• RelA/NFkB p65 Kit
• RelA/NFkB p65 Lysate
• RelA/NFkB p65 Proteins