RelA/NFkB p65 [p Ser276] Antibody

p65 is a subunit of the nuclear factor kappa B. The transcription factor NFkB is widely recognized as a critical mediator of immune and inflammatory responses. In most cell types, NFkB is found in the cytoplasm where it is associated with an inhibitory protein known as IkB. An impressive variety of stimuli (tumor necrosis factor, interleukin 1, T cell activation signals, bacterial endotoxins, viral transforming proteins, certain growth factors and reactive oxygen intermediates) lead to the rapid nuclear accumulation of NFkB by the induced phosphorylation and subsequent degradation of IkB. In the nucleus, NFkB regulates genes encoding cytokines, cytokine receptors, cell adhesion molecules, proteins involved in coagulation and genes involved in cell growth control. Additionally, NFkB is thought to be an important transcriptional regulator for HIV. Growing evidence indicates that the dysregulation of NFkB may be key to a number of diseases including arthritis and other inflammatory diseases, Alzheimer's disease, atherosclerosis and cancer.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 3 applications: IF/IHC, IHC-P, WB.

Showing Publications 1 - 6 of 6.

Publications using NB100-82086	Applications	Species
Masayuki Harada, Kanae Su-Harada, Takeshi Kimura, Koh Ono, Noboru Ashida Sustained activation of NF-kappa B through constitutively active IKK beta leads to senescence bypass in murine dermal fibroblasts Cell Cycle 2024-03-10 [PMID: 38461418]
Gao AY, Diaz Espinosa AM, GianI F et al. Pim-1 Kinase is a Positive Feedback Regulator of the Senescent Lung Fibroblast Inflammatory Secretome American journal of physiology. Lung cellular and molecular physiology 2022-10-12 [PMID: 36223640] (WB, Human)	WB	Human
Daehong Kim, Giljun Park, Jani Huuhtanen, Bishwa Ghimire, Hanna Rajala, Richard Moriggl, Wing C. Chan, Matti Kankainen, Mikko Myllymäki, Satu Mustjoki STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation Leukemia 2021-06-01 [PMID: 34075200]
Kaya S Protective effects of hesperetin on lipopolysaccharide-induced acute lung injury in a rat model Turk Gogus Kalp Dama 2020-04-20 [PMID: 30807747] (IF/IHC, IHC-P, Rat)	IF/IHC, IHC-P	Rat
Zhu Shijun, Moore Terry W, Morii Nao et al. Synthetic curcumin analog UBS109 inhibits the growth of head and neck squamous cell carcinoma xenografts. Curr Cancer Drug Targets. 2014-05-01 [PMID: 24628271]
Zhu S, Moore TW, Lin X et al. Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts. Integr Biol (Camb). 2012-06-01 [PMID: 22532032] (IHC-P, WB, Human)	IHC-P, WB	Human

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Human	04/22/2021	View Summary Application Western Blot Sample Tested HEK293 cell line Species Human Lot 8801

Array NB100-82086

• RelA/NFkB p65 Antibodies
• RelA/NFkB p65 Antibody Pack
• RelA/NFkB p65 ELISA Kits
• RelA/NFkB p65 Inhibitors
• RelA/NFkB p65 Kit
• RelA/NFkB p65 Lysate
• RelA/NFkB p65 Proteins