Recombinant Mouse VCAM-1/CD106 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

VCAM-1 (CD106), a member of the immunoglobulin superfamily, is a cell surface protein expressed by activated endothelial cells and certain leukocytes (such as macrophages). VCAM-1 expression is induced by IL-1 beta , IL-4, TNF-alpha and IFN-gamma . VCAM-1 binds to leukocyte integrins VLA-4 and alpha ₄ beta ₇. The human and mouse VCAM-1 proteins share approximately 76% amino acid similarity.

During the inflammatory adhesion mechanism, activated integrins halt rolling leukocytes and attach them firmly to the vascular endothelium. They do this by binding to their ligands, for example VCAM-1, on endothelium. The VCAM-1: VLA-4/ alpha ₄ beta ₇ interaction is also thought to be involved in the extravasation of white blood cells through the blood vessel wall to sites of inflammation.

ELISA techniques have shown that detectable levels of soluble VCAM-1 are present in the biological fluids of apparently normal individuals. Furthermore, a number of studies have reported that levels of VCAM-1 may be elevated or lowered in subjects with a variety of pathological conditions.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 3 applications: Bioassay, Cell Culture, Flow Cytometry.

Showing Publications 1 - 10 of 50. Show All 50 Publications. Collapse Publications.

Publications using 643-VM	Applications	Species
Haage, TR;Charakopoulos, E;Bhuria, V;Baldauf, CK;Korthals, M;Handschuh, J;Müller, P;Li, J;Harit, K;Nishanth, G;Frey, S;Böttcher, M;Fischer, KD;Dudeck, J;Dudeck, A;Lipka, DB;Schraven, B;Green, AR;Müller, AJ;Mougiakakos, D;Fischer, T; Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia Journal of hematology & oncology 2024-06-09 [PMID: 38853260] (Bioassay, Mouse)	Bioassay	Mouse
Juilland, M;Alouche, N;Ubezzi, I;Gonzalez, M;Rashid, HO;Scarpellino, L;Erdmann, T;Grau, M;Lenz, G;Luther, SA;Thome, M; Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination Proceedings of the National Academy of Sciences of the United States of America 2023-12-26 [PMID: 38109544] (Bioassay, Mouse)	Bioassay	Mouse
Park, JS;Kim, JH;Soh, WC;Kim, NY;Lee, KS;Kim, CH;Chung, IJ;Lee, S;Kim, HR;Jun, CD; Trogocytic molting of T cell microvilli upregulates T cell receptor surface expression and promotes clonal expansion Nature communications 2023-05-24 [PMID: 37221214] (Bioassay, Mouse)	Bioassay	Mouse
YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08-24;8(34):eabn5522. 2022-08-24 [PMID: 36001668] (Cell Culture, Human)	Cell Culture	Human
S Sevilla-Mo, P Fuentes, Y Rodríguez-, N Arellano-S, PW Krenn, SI de Val, S Montero-He, J García-Cec, V Burdiel-He, SR Gardeta, N Aguilera-M, C Barrio-Alo, G Crainiciuc, D Bouvard, A García-Par, AG Zapata, A Hidalgo, R Fässler, YR Carrasco, ML Toribio, J Teixidó ICAP-1 loss impairs CD8+ thymocyte development and leads to reduced marginal zone B cells in mice European Journal of Immunology, 2022-05-13;0(0):. 2022-05-13 [PMID: 35491946] (Bioassay, Mouse)	Bioassay	Mouse
CM Lee, ML Chang, RH Chen, FW Chen, JC Liu, SL Kuo, HH Peng Thrombin-Activated Platelets Protect Vascular Endothelium against Tumor Cell Extravasation by Targeting Endothelial VCAM-1 International Journal of Molecular Sciences, 2022-03-22;23(7):. 2022-03-22 [PMID: 35408794] (Cell Culture, Mouse)	Cell Culture	Mouse
Z Benet, Z Jing, DR Fooksman Plasma cell dynamics in the bone marrow niche Cell Reports, 2021-02-09;34(6):108733. 2021-02-09 [PMID: 33567286] (Bioassay, Mouse)	Bioassay	Mouse
NH Roy, SHJ Kim, A Buffone, D Blumenthal, B Huang, S Agarwal, PL Schwartzbe, DA Hammer, JK Burkhardt LFA-1 signals to promote actin polymerization and upstream migration in T cells J. Cell. Sci., 2020-09-09;133(17):. 2020-09-09 [PMID: 32907931] (Bioassay, Mouse)	Bioassay	Mouse
V Azcutia, M Kelm, AC Luissint, K Boerner, S Flemming, M Quiros, G Newton, A Nusrat, FW Luscinskas, CA Parkos Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo Mucosal Immunol, 2020-06-19;0(0):. 2020-06-19 [PMID: 32561828] (Bioassay, Mouse)	Bioassay	Mouse
V Barbier, J Erbani, C Fiveash, JM Davies, J Tay, MR Tallack, J Lowe, JL Magnani, DR Pattabiram, AC Perkins, J Lisle, JEJ Rasko, JP Levesque, IG Winkler Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance Nat Commun, 2020-04-27;11(1):2042. 2020-04-27 [PMID: 32341362] (Bioassay, Mouse)	Bioassay	Mouse
K Birkner, B Wasser, T Ruck, C Thalman, D Luchtman, K Pape, S Schmaul, L Bitar, EM Krämer-Alb, A Stroh, SG Meuth, F Zipp, S Bittner beta1-integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells J. Clin. Invest., 2020-02-03;0(0):. 2020-02-03 [PMID: 31661467] (Mouse)		Mouse
MC Schmid, SQ Khan, MM Kaneda, P Pathria, R Shepard, TL Louis, S Anand, G Woo, C Leem, MH Faridi, T Geraghty, A Rajagopala, S Gupta, M Ahmed, RI Vazquez-Pa, DA Cheresh, V Gupta, JA Varner Integrin CD11b activation drives anti-tumor innate immunity Nat Commun, 2018-12-19;9(1):5379. 2018-12-19 [PMID: 30568188] (Bioassay, Mouse)	Bioassay	Mouse
J Chen, N Li, Y Yin, N Zheng, M Min, B Lin, L Zhang, X Long, Y Zhang, Z Cai, S Zhai, J Qin, X Wang Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells Cell Rep, 2018-12-18;25(12):3393-3404.e6. 2018-12-18 [PMID: 30566865] (Bioassay, Mouse)	Bioassay	Mouse
V Andreani, S Ramamoorth, A Pandey, E Lupar, SL Nutt, T Lämmermann, R Grosschedl Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and ?1-integrin function Proc. Natl. Acad. Sci. U.S.A., 2018-09-26;0(0):. 2018-09-26 [PMID: 30257949] (Bioassay, Mouse)	Bioassay	Mouse
FA Moretti, S Klapproth, R Ruppert, A Margraf, J Weber, R Pick, C Scheierman, M Sperandio, R Fässler, M Moser Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus Elife, 2018-09-06;7(0):. 2018-09-06 [PMID: 30187863] (Mouse)		Mouse
A Farinazzo, S Angiari, E Turano, E Bistaffa, S Dusi, S Ruggieri, R Bonafede, R Mariotti, G Constantin, B Bonetti Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis Sci Rep, 2018-05-10;8(1):7473. 2018-05-10 [PMID: 29748664] (Bioassay, Mouse)	Bioassay	Mouse
K Morita, C Tokushige, S Maeda, H Kiyose, M Noura, A Iwai, M Yamada, G Kashiwazak, J Taniguchi, T Bando, M Hirata, TR Kataoka, T Nakahata, S Adachi, H Sugiyama, Y Kamikubo RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice Blood Adv, 2018-03-13;2(5):509-515. 2018-03-13 [PMID: 29500219] (Bioassay, Mouse)	Bioassay	Mouse
M Praetner, G Zuchtriege, M Holzer, B Uhl, J Schaubäche, L Mittmann, M Fabritius, R Fürst, S Zahler, D Funken, M Lerchenber, A Khandoga, S Kanse, K Lauber, F Krombach, CA Reichel Plasminogen Activator Inhibitor-1 Promotes Neutrophil Infiltration and Tissue Injury on Ischemia-Reperfusion Arterioscler. Thromb. Vasc. Biol., 2018-01-25;0(0):. 2018-01-25 [PMID: 29371242] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
S Sarvi, H Patel, J Li, GL Dodd, H Creedon, M Muir, J Ward, JC Dawson, M Lee, J Culley, DM Salter, AH Sims, A Byron, VG Brunton Kindlin-1 promotes pulmonary breast cancer metastasis Cancer Res., 2018-01-12;0(0):. 2018-01-12 [PMID: 29330144] (Bioassay, Mouse)	Bioassay	Mouse
S Paetau, T Rolova, L Ning, CG Gahmberg Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia Front Mol Neurosci, 2017-12-22;10(0):431. 2017-12-22 [PMID: 29311819] (Bioassay, Mouse)	Bioassay	Mouse
CP Basole, RK Nguyen, K Lamothe, A Vang, R Clark, GS Baillie, PM Epstein, S Brocke PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex Cell. Signal., 2017-08-26;40(0):62-72. 2017-08-26 [PMID: 28851628] (Bioassay, Mouse)	Bioassay	Mouse
PJ Stewart-Hu, TP Szasz, ER Jaeger, MD Onken, JA Cooper, SC Morley Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate J. Leukoc. Biol., 2017-06-21;0(0):. 2017-06-21 [PMID: 28637896] (Bioassay, Mouse)	Bioassay	Mouse
KJ Chung, A Chatzigeor, M Economopou, R Garcia-Mar, VI Alexaki, I Mitroulis, M Nati, J Gebler, T Ziemssen, SE Goelz, J Phieler, JH Lim, KP Karalis, T Papayannop, M Blüher, G Hajishenga, T Chavakis A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity Nat. Immunol., 2017-04-17;0(0):. 2017-04-17 [PMID: 28414311] (Bioassay, Mouse)	Bioassay	Mouse
S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1 Nat. Methods, 2017-04-10;14(5):531-538. 2017-04-10 [PMID: 28394335] (Bioassay, Mouse)	Bioassay	Mouse
ML Estin, SB Thompson, B Traxinger, MH Fisher, RS Friedman, J Jacobelli Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration Proc. Natl. Acad. Sci. U.S.A, 2017-03-20;0(0):. 2017-03-20 [PMID: 28320969] (Bioassay, Mouse)	Bioassay	Mouse
Y Hirano, WL Yang, M Aziz, F Zhang, B Sherry, P Wang MFG-E8-derived peptide attenuates adhesion and migration of immune cells to endothelial cells J. Leukoc. Biol, 2017-01-17;0(0):. 2017-01-17 [PMID: 28096298] (Bioassay, Mouse)	Bioassay	Mouse
Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties Sci Rep, 2016-11-29;6(0):37914. 2016-11-29 [PMID: 27897208] (Bioassay, Mouse)	Bioassay	Mouse
Aged neutrophils contribute to the first line of defense in the acute inflammatory response Blood, 2016-09-08;0(0):. 2016-09-08 [PMID: 27609642] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
A Critical Role for P2X7 Receptor-Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury J Immunol, 2016-08-24;0(0):. 2016-08-24 [PMID: 27559050] (Bioassay, Rat)	Bioassay	Rat
Henriette Rudolph Post-arrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro Eur J Immunol, 2016-07-22;0(0):. 2016-07-22 [PMID: 27338806] (Bioassay, Mouse)	Bioassay	Mouse
Platelets Guide Leukocytes to Their Sites of Extravasation PLoS Biol, 2016-05-06;14(5):e1002459. 2016-05-06 [PMID: 27152726] (Bioassay, Mouse)	Bioassay	Mouse
Martin-Blondel G, Pignolet B, Tietz S, Yshii L, Gebauer C, Perinat T, Van Weddingen I, Blatti C, Engelhardt B, Liblau R Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the alpha4beta1-integrin. Eur J Immunol, 2015-10-06;45(12):3302-12. 2015-10-06 [PMID: 26358409] (Bioassay, Mouse)	Bioassay	Mouse
Lemaire M, Negro Silva L, Lemarie C, Bolt A, Flores Molina M, Krohn R, Smits J, Lehoux S, Mann K Arsenic Exposure Increases Monocyte Adhesion to the Vascular Endothelium, a Pro-Atherogenic Mechanism. PLoS ONE, 2015-09-02;10(9):e0136592. 2015-09-02 [PMID: 26332580] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Boularan C, Hwang I, Kamenyeva O, Park C, Harrison K, Huang Z, Kehrl J B Lymphocyte-Specific Loss of Ric-8A Results in a Galpha Protein Deficit and Severe Humoral Immunodeficiency. J Immunol, 2015-07-31;195(5):2090-102. 2015-07-31 [PMID: 26232433] (Bioassay, Mouse)	Bioassay	Mouse
Totsuka N, Kim Y, Kanemaru K, Niizuma K, Umemoto E, Nagai K, Tahara-Hanaoka S, Nakahasi-Oda C, Honda S, Miyasaka M, Shibuya K, Shibuya A Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration. Nat Commun, 2014-08-19;5(0):4710. 2014-08-19 [PMID: 25134989] (Bioassay, Mouse)	Bioassay	Mouse
Palmi C, Fazio G, Savino A, Procter J, Howell L, Cazzaniga V, Vieri M, Longinotti G, Brunati I, Andre V, Della Mina P, Villa A, Greaves M, Biondi A, D'Amico G, Ford A, Cazzaniga G Cytoskeletal regulatory gene expression and migratory properties of B-cell progenitors are affected by the ETV6-RUNX1 rearrangement. Mol Cancer Res, 2014-07-24;12(12):1796-806. 2014-07-24 [PMID: 25061103] (Bioassay, Mouse)	Bioassay	Mouse
Gobel K, Schuhmann M, Pankratz S, Stegner D, Herrmann A, Braun A, Breuer J, Bittner S, Ruck T, Wiendl H, Kleinschnitz C, Nieswandt B, Meuth S Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis. Eur J Immunol, 2014-06-05;44(8):2295-305. 2014-06-05 [PMID: 24811005] (Bioassay, Mouse)	Bioassay	Mouse
Wang X, Rodda L, Bannard O, Cyster J Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness. J Immunol, 2014-04-16;192(10):4601-9. 2014-04-16 [PMID: 24740506] (Bioassay, Mouse)	Bioassay	Mouse
Gonzalvo-Feo S, Del Prete A, Pruenster M, Salvi V, Wang L, Sironi M, Bierschenk S, Sperandio M, Vecchi A, Sozzani S Endothelial cell-derived chemerin promotes dendritic cell transmigration. J Immunol, 2014-01-27;192(5):2366-73. 2014-01-27 [PMID: 24470498] (Bioassay, Mouse)	Bioassay	Mouse
Chen Y, Molnar M, Li L, Friberg P, Gan L, Brismar H, Fu Y Characterization of VCAM-1-binding peptide-functionalized quantum dots for molecular imaging of inflamed endothelium. PLoS ONE, 2013-12-31;8(12):e83805. 2013-12-31 [PMID: 24391829] (Bioassay, Mouse)	Bioassay	Mouse
Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T A circadian clock gene, Rev-erbalpha, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression. J Immunol, 2013-12-04;192(1):407-17. 2013-12-04 [PMID: 24307731] (Bioassay, Mouse)	Bioassay	Mouse
Lee J, Sohn J, Ryu S, Hong C, Moon K, Park J A novel human anti-VCAM-1 monoclonal antibody ameliorates airway inflammation and remodelling. J Cell Mol Med, 2013-07-16;17(10):1271-81. 2013-07-16 [PMID: 23855490] (Bioassay, Human)	Bioassay	Human
Schmid M, Franco I, Kang S, Hirsch E, Quilliam L, Varner J PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth. PLoS ONE, 2013-04-02;8(4):e60226. 2013-04-02 [PMID: 23565202] (Bioassay, Mouse)	Bioassay	Mouse
Harker K, Ueno N, Wang T, Bonhomme C, Liu W, Lodoen M Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress. J Leukoc Biol, 2013-03-13;93(5):789-800. 2013-03-13 [PMID: 23485448] (Bioassay, Human)	Bioassay	Human
Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH Difference in Th1 and Th17 lymphocyte adhesion to endothelium. J. Immunol., 2012-01-04;188(3):1421-30. 2012-01-04 [PMID: 22219321] (Bioassay, Mouse)	Bioassay	Mouse
Moser M, Bauer M, Schmid S, Ruppert R, Schmidt S, Sixt M, Wang HV, Sperandio M, Fassler R Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat. Med., 2009-02-22;15(3):300-5. 2009-02-22 [PMID: 19234461] (Bioassay, Mouse)	Bioassay	Mouse
Sasaki K, Pardee AD, Okada H, Storkus WJ IL-4 inhibits VLA-4 expression on Tc1 cells resulting in poor tumor infiltration and reduced therapy benefit. Eur. J. Immunol., 2008-10-01;38(10):2865-73. 2008-10-01 [PMID: 18958887] (Bioassay, Mouse)	Bioassay	Mouse
Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, Ninio E, van Haperen R, de Crom R, Tedgui A, Lehoux S High pressure promotes monocyte adhesion to the vascular wall. Circ. Res., 2007-03-29;100(8):1226-33. 2007-03-29 [PMID: 17395876] (Bioassay, Human)	Bioassay	Human
Kelly KA, Allport JR, Yu AM, Sinh S, Sage EH, Gerszten RE, Weissleder R SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration. J. Leukoc. Biol., 2006-12-18;81(3):748-56. 2006-12-18 [PMID: 17178915] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Cardones AR, Murakami T, Hwang ST CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin. Cancer Res., 2003-10-15;63(20):6751-7. 2003-10-15 [PMID: 14583470] (Bioassay, Flow Cytometry, Mouse)	Bioassay, Flow Cytometry	Mouse
Show All 50 Publications. Collapse Publications.

Array 643-VM

• VCAM-1/CD106 Antibodies
• VCAM-1/CD106 Antibody Pair
• VCAM-1/CD106 ELISA Kits
• VCAM-1/CD106 Lysate
• VCAM-1/CD106 Proteins
• VCAM-1/CD106 ELISAs
• VCAM-1/CD106 Proteins and Enzymes